Efficacy of Statins in Dyslipidemia: A Non interventional comparative study in a tertiary care hospital, Ajman, UAE

John, Lisha Jenny; Esheiba, EM; Fathi, Mam; Agarwal, AK; Sreedharan, Jayadevan; Muttappallymyalil, Jayakumary; Shantakumari, Nisha

doi:10.3126/nje.v4i5.12023

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Lipid profile is influenced by several factors including genetics, lifestyle and dietary factors [1] and although modifiable, dyslipidemia remains a leading risk factor for metabolic syndrome and cardiovascular disease such as coronary heart disease (CHD) [2,3]. According to World Health Organization (WHO), 4 million deaths are attributed to CHD worldwide per year [4], and 70% of patients with premature CHD symptoms demonstrate abnormal lipid metabolism. Earlier work has demonstrated that for every 10% reduction in serum total cholesterol (TC) levels, there is a 15% decline in CHD-linked mortality risk [5], highlighting the importance of dyslipidemia in CHD progression and the need to improve serum lipids in patients with dyslipidaemia.…”

Section: Introductionmentioning

confidence: 99%

The effects of green coffee bean extract supplementation on lipid profile in humans: A systematic review and meta-analysis of randomized controlled trials

Ding

Nazary-Vannani

et al. 2020

Nutrition, Metabolism and Cardiovascular Diseases

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Background and aim: This systematic review and meta-analysis aimed to assess the effects of green coffee bean extract (GCBE) supplementation on lipid profile in adults. Methods and results: The PubMed/Medline, Scopus, Web of sciences, and Google Scholar were systematically searched for randomized controlled trials available in English and published before February 2019. The meta-analysis was conducted using fixed effects models, and between-study heterogeneity was assessed by Cochran's Q test and I 2 . A total of 17 effect sizes were included in the meta-analysis. Combined effect sizes on serum total cholesterol concentrations revealed significant effects of GCBE supplementation on serum total cholesterol [weighted mean difference (WMD): À4.51 mg/dL, 95% confidence interval (CI): À6.89, À2.12, p < 0.001], low density lipoprotein-cholesterol (LDL-C) (WMD: À4.38 mg/dL, 95% CI: À6.44, À2.31, p < 0.001), and high density lipoprotein-cholesterol (HDL-C) (WMD: 2.63 mg/dL, 95% CI: 2.20, 3.07, p < 0.001) compared to controls. Nevertheless, no significant changes were observed in serum triglycerides levels (WMD: À4.34 mg/dL, 95% CI: À9.00, 0.32, p Z 0.068). Conclusion:The evidence from available studies suggests that the GCBE supplementation leads to significant reductions in total cholesterol, HDL-C, and LDL-C levels, and has modest, but, nonsignificant effects on triglycerides levels.

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Section: Introductionmentioning

confidence: 99%

The effects of green coffee bean extract supplementation on lipid profile in humans: A systematic review and meta-analysis of randomized controlled trials

Ding

Nazary-Vannani

et al. 2020

Nutrition, Metabolism and Cardiovascular Diseases

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“…A prospective 12-week study in 70 patients with newly diagnosed dyslipidemia in UAE showed the effectiveness of atorvastatin, simvastatin and rosuvastatin after 12 weeks of treatment (John et al, 2014). A cross-sectional study in Kuwait showed lower adherence to statin compared to the study reports from Canada and the US (Al-Foraih and Somerset, 2017).…”

Section: Figure 1: the Difference In Lipid Pro Ile At The Follow-up Vmentioning

confidence: 96%

Lipid profile outcome gaps of Arabs and South Asians receiving chronic Statin therapy

Alagheband¹,

Zachariah²,

Thomas³

2020

ijrps

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Ethnicity is a variable in statin response, but the influence of it in Arabs and South Asians is not known. There is a possibility of under-treatment in the long-term management of dyslipidemia in the Arab population, ignoring post-initiation medication nonadherence and lifestyle. There could be potential genetic reasons also for the need for higher lipid-lowering therapy in Arabs. This study is to identify lipid profile outcome gaps of Arabs and South Asians who were receiving chronic statin therapy. A hypothesis generating retrospective cohort study was conducted to compare lipid profiles among patients treated with a statin for more than three months. The study compared two lipid profiles of Arab and South Asian patients on chronic management of dyslipidemia. T-test and Z-test were performed to compare the lipid profiles. The study participants included 42 Arabs and 28 South Asians. Arabs had a higher body mass index (P-value 0.05), and more of them were smokers compared to South Asians (P-value 0.04). Total cholesterol (P-value 0.03, 95%CI 1.08 to -21.29) and LDL cholesterol (P-value 0.03, 95% CI 0.51 to -17.51) reductions in 3 – 6 months were significant in South Asians, but not in Arabs. The lipid profiles in Arabs receiving chronic statin therapy might be poor compared to South Asians. Both populations need improvements in lipid-lowering therapy outcomes. This hypothesis should be studied further to prove inherent differences and poor therapy outcomes among Arab and South Asian population that might result in modifications in current healthcare management policies.

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The effects of chromium supplementation on lipidprofile in humans: A systematic review and meta-analysis ofrandomized controlled trials

Tarrahi

Rafiee

Mansourian

2021

Pharmacological Research

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Efficacy of Statins in Dyslipidemia: A Non interventional comparative study in a tertiary care hospital, Ajman, UAE

Abstract: Background

Cited by 3 publications

References 16 publications

The effects of green coffee bean extract supplementation on lipid profile in humans: A systematic review and meta-analysis of randomized controlled trials

The effects of green coffee bean extract supplementation on lipid profile in humans: A systematic review and meta-analysis of randomized controlled trials

Lipid profile outcome gaps of Arabs and South Asians receiving chronic Statin therapy

The effects of chromium supplementation on lipidprofile in humans: A systematic review and meta-analysis ofrandomized controlled trials

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