Efficacy of supplementation of probiotics on maternal glycaemic control – A systematic review and meta-analysis of randomized controlled trials

Ramanathan, Kavitha; Jagadeesh, Nalini Sirala; Vishwanath, Usha; Dayal, Celina; Chandrababu, Ramesh; Hayter, Mark

doi:10.1016/j.cegh.2020.11.007

Cited by 9 publications

(3 citation statements)

References 28 publications

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“…Although the presence of heterogeneity was substantial, the point estimates for the majority of the included studies were in the same direction favoring probiotics. Our findings on FPG corroborated the previous meta-analyses [ 27 , 35 , 37 , 38 , 44 ] that reported the effects of probiotics on glycemic outcomes in GDM. By contrast, Han et al [ 43 ] reported no significant reduction in FPG after probiotics supplementation in women with GDM.…”

Section: Discussionsupporting

confidence: 91%

“…Improvement in fasting serum insulin and HOMA-IR indicates the potential roles of probiotics in improving insulin sensitivity [ 41 ]. Ramanathan et al [ 38 ] reported that probiotics supplementation has favorable effects on FPG and insulin, but their analysis included pregnant women with and without GDM [ 38 ]. Meanwhile, our meta-analysis suggested that probiotics have no significant effect on lipid parameters, and our findings are in agreement with the results of previously published meta-analyses [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…Previous meta-analyses explored the effects of probiotic intervention on glycemic control [35][36][37][38][39][40][41][42], and limited meta-analyses analyzed lipid metabolism [39,40,43,44], inflammatory [27,44], oxidative stress [27,44], and pregnancy outcomes in pregnant women with GDM [41,43,44]. The majority of these reviews suggested that probiotic supplementation has beneficial effects on glycemic outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Diet and Pre-Intervention Washout Modifies the Effects of Probiotics on Gestational Diabetes Mellitus: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2021

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Dynamic interactions among gestational diabetes mellitus (GDM), gut microbiota, inflammation, oxidative stress, and probiotics are increasingly acknowledged. This meta-analysis aimed to summarize the effects of probiotics in GDM, focusing on lifestyle intervention and pre-intervention washout, in addition to metabolic, inflammation, oxidative stress, and pregnancy outcomes. Three electronic databases (i.e., PubMed, Scopus, and CENTRAL) were searched from inception until October 2020. A meta-analysis was performed, and the effect sizes were reported as either mean differences or odds ratios with 95% confidence intervals. Altogether, 10 randomized controlled trials enrolling 594 participants were included. The meta-analysis indicated that probiotics supplementation effectively reduced fasting plasma glucose by 3.10 mg/dL, and subgroup analyses suggested that the duration of intervention, number of species, pre-intervention washout period, and dietary intervention may determine the effects of probiotics. Probiotics also reduced the level of inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-α, and malondialdehyde), incidence of macrosomia, and newborn hospitalization. In conclusion, this meta-analysis suggests that probiotics may have positive effects on metabolic, inflammation, oxidative stress, and neonatal outcomes in women with GDM. Additionally, diet and pre-intervention washout may modify the effects of probiotics. Future studies are warranted on a larger scale to ascertain the clinical significance.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diet and Pre-Intervention Washout Modifies the Effects of Probiotics on Gestational Diabetes Mellitus: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2021

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Effect of probiotics on pregnancy outcomes in gestational diabetes: systematic review and meta-analysis

Wu,

Luan,

et al. 2024

Arch Gynecol Obstet

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Background: Gestational diabetes is a common complication during pregnancy that can lead to numerous adverse outcomes. Some studies suggest that probiotics may be used to treat gestational diabetes, however, the results remain controversial. We conducted a systematic review and meta-analysis to evaluate the effect of probiotics on blood glucose and pregnancy outcomes in women with gestational diabetes. Methods: A systematic search of PubMed, Embase, and Cochrane databases was performed (start date to August 22, 2023). Primary outcomes included fasting blood sugar (FBS), fasting serum insulin (FSI), homeostasis model assessment of insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (QUICKI). Secondary outcomes included pregnancy and neonatal outcomes. Results: 15 articles (n = 1006 women) met the inclusion criteria and were included in the analysis. Compared to a placebo, probiotics can decrease FBS (MD -2.58, 95% CI -4.38 to -0.79, p < 0.01), FSI (MD -2.29, 95% CI -3.40 to -1.18, p < 0.01), HOMA-IR (MD -0.56, 95% CI -0.81 to -0.32, p < 0.01), birthweight (MD -101.20, 95% CI -184.62 to -17.77, p = 0.02), neonatal intensive care unit (NICU) (RR 0.60, 95% CI 0.40 to 0.89, p = 0.01), and hyperbilirubinemia (RR 0.31, 95% CI 0.16 to 0.61, p < 0.01), alongside higher QUICKI (MD 0.01, 95% CI 0.00 to 0.01, p < 0.01). However, no other significant results were obtained. Conclusion: Probiotics may improve blood glucose indicators and reduce neonatal hyperbilirubinemia, NICU admissions, and birth weight in women with GDM.

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Probiotics in the management of diabetes

et al. 2022

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Efficacy of supplementation of probiotics on maternal glycaemic control – A systematic review and meta-analysis of randomized controlled trials

Cited by 9 publications

References 28 publications

Diet and Pre-Intervention Washout Modifies the Effects of Probiotics on Gestational Diabetes Mellitus: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials

Diet and Pre-Intervention Washout Modifies the Effects of Probiotics on Gestational Diabetes Mellitus: A Comprehensive Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effect of probiotics on pregnancy outcomes in gestational diabetes: systematic review and meta-analysis

Probiotics in the management of diabetes

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