Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage

Abstract

Bone marrow stromal cells (BMSCs) may differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease remains unclear. The aim is to assess the safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs transplantation for treating ICH. 206 ICH patients who had received surgical procedure were divided into transplantation (n = 110) or control group (n = 96). For transplantation group, BMSCs were injected into the perihemorrhage area in the base ganglia through an intracranial drainage tube 5.5 (3.01–6.89) days after surgery, followed by a second injection into the subarachnoid space through lumbar puncture 4 weeks later. Neurologic impairment and daily activities were assessed with National Institute Stroke Scale (NIHSS), Barthel index, and Rankin scale before transplantation and 6 months and 12 months after transplantation. Our results revealed that, compared with control group, NIHSS score and Rankin scale were both significantly decreased but Barthel index was increased in transplantation group after 6 months. Interestingly, no significant difference was observed between 12 months and 6 months. No transplantation-related adverse effects were investigated during follow-up assessments. Our findings suggest that surgery combined with autologous BMSCs transplantation is safe for treatment of ICH, providing short-term therapeutic benefits.

Safety and effectiveness of stem cell therapies in early-phase clinical trials in stroke: a systematic review and meta-analysis

“…The majority of studies (n=18) utilised autologous adult human bone marrow-derived mesenchymal/mononuclear cells [ 13 , 16 – 22 , 24 - 26 , 30 – 34 , 36 , 37 , 39 ]. The remaining studies utilised varied allogeneic cell sources such as human neural stem cells derived from fetal tissue (n=3) [ 15 , 29 , 38 ], mesenchymal cells from umbilical cord blood (n=1) [ 23 ], neuronal cells derived from embryonic tissue ( n = 2) [ 12 , 14 ] and autologous peripheral blood haematopoietic stem cells ( n = 1).…”

Review of Preclinical and Clinical Studies of Bone Marrow‐Derived Cell Therapies for Intracerebral Hemorrhage

“…Zhu and collaborators [ 78 ] carried out a clinical trial where 215 patients with ICH were included. Following surgical drainage and decompressive craniotomy, 114 patients agreed to receive the cell therapy while the remaining 101 patients participated as a control group.…”

Outcomes of Bone Marrow Mononuclear Cell Transplantation for Neurological Sequelae Due to Intracranial Hemorrhage Incidence in the Neonatal Period: Report of Four Cases

“…Zhu et al compared outcomes of surgery combined with autologous bone marrow stromal cell transplantation vs. surgery alone for treatment of intra-cerebral hemorrhage. The findings of this trial showed that surgery combined with autologous bone marrow stromal cell transplantation is safe, providing short-term therapeutic benefits for ICH (36).…”