Efficacy of Switching from Cyclosporine A 0.05% Anionic Emulsion to Cyclosporine A 0.1% Cationic Emulsion in Patients with Dry Eye Associated with Sjögren's Syndrome

Kim, Jonghwa; Moon, Tae Kyu; Yoon, Hyeon Jeong; Ji, Yong Sok; Yoon, Kyung Chul

doi:10.1089/jop.2020.0146

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…Similarly, Kim et al . 34 found no significant changes in the Schirmer test scores. In contrast, a study reported that the Schirmer test had a higher value in the cyclosporine 0.05% group compared to the normal saline 0.9% at 3 months 4 .…”

Section: Discussionmentioning

confidence: 66%

Evaluation of cyclosporine 0.05% and artificial tears for the management of dry eye disease following cataract surgery: a randomized controlled trial

Ahmadi,

Tahmasbian,

Janbazi

et al. 2024

Annals of Medicine &Amp; Surgery

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Purpose: To compare the effects of cyclosporine 0.05% and artificial tears on dry eye disease following cataract surgery. Methods: This prospective, double-masked, randomized clinical trial enrolled 60 eyes of 60 eligible cataract patients who completed the study. Patients were randomized to receive either cyclosporine 0.05% or artificial tear four times daily for one month following cataract surgery. Clinical assessments included refraction, corrected distance visual acuity, tear break up time (TBUT), Schirmer’s test, and the visual analogue scale (VAS). An independent sample t-test was used to compare the means of the variables between the two groups. Results: Mean patient age was 64.15±9.17 (range, 45-90), of which 53% (n=32) were female. There was no significant difference in mean age (P=0.308) between the two groups. One month postoperatively, the cyclosporine 0.05% group had a significantly higher TBUT value (P=0.004). Schirmer’s result (P=0.095) and the VAS questionnaire scores (P=0.374) did not show a statistically significant difference between the two groups. There was no significant difference in the visual outcomes (P>0.05). Conclusion: Cyclosporine 0.05% was superior to artificial tears in improving tear stability after cataract surgery in the management of immediate postoperative dry eye. It may provide a more effective therapeutic option for the management of dry eye symptoms in the clinical setting.

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Section: Discussionmentioning

confidence: 66%

Evaluation of cyclosporine 0.05% and artificial tears for the management of dry eye disease following cataract surgery: a randomized controlled trial

Ahmadi,

Tahmasbian,

Janbazi

et al. 2024

Annals of Medicine &Amp; Surgery

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“…Briefly, a prospective study comparing 0.03% tacrolimus and 0.05% cyclosporine did not find any significant difference between arms (89), while a partial improvement was demonstrated after switching from cyclosporine A 0.05% anionic emulsion to 0.1% cationic emulsion, though with no control group (90). Interestingly, however, a trial suggested that the irrigation of salivary glands by sialendoscopy can significantly improve salivary flow, xerostomy and ESSPRI, likely through a mechanical action that opens ducts, removes debris, microliths and mucus (91).…”

Section: Take Home Messagesmentioning

confidence: 99%

Sjögren's syndrome: one year in review 2022

Manfrè

Chatzis

Cafaro

et al. 2022

Clinical and Experimental Rheumatology

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Primary Sjögren's syndrome (pSS) is a complex disabling systemic autoimmune disorder. The hallmark of pSS is the T-cell-mediated hyperactivation of B-cells, evolving from asymptomatic conditions to systemic complications and lymphoma development. On tissue level, the typical feature is the lymphocytic infiltration of the salivary gland by B-, T-and antigen presenting cells, as mirrored by the diagnostic cornerstone role of minor salivary gland (MSG) biopsy. B-cells show multiple possible roles in disease pathogenesis, from autoantibody production, to antigen presentation, and cytokine production. B-cells hyperactivation is supported by genetic risk factors, T-cell dependent and independent mechanisms, and the presence of different pathogenic B-cell subsets must be reminded. Many aspects have been investigated in the last year regarding genetic and epigenetics, B-and T-cell role in pSS pathogenesis, their interaction with salivary gland epithelial cells (SGECs) and in their direct or indirect use as biomarkers and predictors of disease development, activity, and lymphomagenesis.In this review, following the others of this series, we will summarise the most recent literature on pSS pathogenesis and clinical features focusing in particular on new insights into pSS molecular stratification and therapeutic advances in the era of precision medicine.

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Ciclosporin A Cationic Emulsion 0.1% for the Management of Dry Eye Disease: Facts That Matter for Eye-Care Providers

Labétoulle

Leonardi

Pisella

et al. 2022

Ocular Immunology and Inflammation

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Efficacy of Switching from Cyclosporine A 0.05% Anionic Emulsion to Cyclosporine A 0.1% Cationic Emulsion in Patients with Dry Eye Associated with Sjögren's Syndrome

Cited by 4 publications

References 31 publications

Evaluation of cyclosporine 0.05% and artificial tears for the management of dry eye disease following cataract surgery: a randomized controlled trial

Evaluation of cyclosporine 0.05% and artificial tears for the management of dry eye disease following cataract surgery: a randomized controlled trial

Sjögren's syndrome: one year in review 2022

Ciclosporin A Cationic Emulsion 0.1% for the Management of Dry Eye Disease: Facts That Matter for Eye-Care Providers

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