Efficacy of systemic antibiotics in nonsurgical periodontal therapy for diabetic subjects: a systematic review and meta-analysis

Abstract

When the data for all antibiotic protocols were considered together for the treatment of periodontitis patients with DM, a significant, albeit small, reduction of PPD and no improvement in CAL gain was observed. When the antibiotic protocols were analysed separately, the combination of amoxicillin plus metronidazole yielded the best results for PPD.

The effects of non‐surgical periodontal therapy on glycemic control in diabetic patients: A randomized controlled trial

“…Furthermore, the data from the present study demonstrated that the use of a combination of amoxicillin and metronidazole as adjunctive to SRP yielded considerable clinical and metabolic advantages at 3‐month follow‐up period. This is in accordance with Souto et al () who reported that non‐surgical periodontal treatment using a combination of amoxicillin and metronidazole in diabetic patients associated with best clinical results (Souto et al, ).…”

The effects of periodontal treatment on diabetic patients: The DIAPERIO randomized controlled trial

“…Neither can our “negative” result be explained by any periodontal procedure in the control group, since our control group was a true “no treatment” control arm. One drawback of our “optimal periodontal treatment” approach is that recent research shows that it is the combination of amoxicillin and metronidazole that yields the best clinical results in nonsurgical periodontal therapy for diabetic subjects (Souto et al., ).…”

“…The antibiotic therapy was prescribed to comply with French recommendations for the prevention of local infection following invasive oral treatments in patients with uncontrolled diabetes (FSOS, ). Furthermore, systemic antibiotics in nonsurgical periodontal therapy for diabetic subjects could lead to a modest additional improvement in periodontal parameters (Grellmann, Sfreddo, Maier, Lenzi, & Zanatta, ; Souto et al., ). SRP was performed over the 10‐day period following the inclusion visit for the immediate treatment group (Supporting information Figure ).…”

Periodontal Disease in Diabetes Mellitus: A Case–Control Study in Smokers and Non-Smokers

“…In this study, we used the classification introduced by Fernandes et al [ 16 ]: (1) the participant is considered to have a healthy periodontal status if no CAL or BOP can be detected; (2) early PD is defined as CAL ≥ 1 mm at ≥ 2 teeth; (3) moderate PD is defined as CAL ≥ 4 mm at 3 locations and PPD ≥ 3 mm in at least 2 locations; (4) severe PD is defined as CAL ≥ 6 mm at ≥ 2 teeth and PPD ≥ 5 mm at ≥ 1 location. To characterize the groups in more detail, we calculated and recorded PPD and CAL separately for each participant, as recommended in other studies [ 60 , 61 ].…”