Efficacy of Tamsulosin Oral Controlled Absorption System After Extracorporeal Shock Wave Lithotripsy to Treat Urolithiasis

Georgiev, М.; Ormanov, Д.; Vassilev, Vasil D.; Dimitrov, P.; Mladenov, В.; Popov, Elenko; Simeonov, P; Panchev, P

doi:10.1016/j.urology.2011.01.073

Cited by 21 publications

(16 citation statements)

References 17 publications

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“…3,5 Several variables play an incountournable role in the migration of calculi: stone size, intrinsic areas of narrowing within the ureter, ureteral peristalsis, and hydrostatic pressure of the column of urine proximal to the stone, edema, urinary tract infection, and spasm of the ureteral sire in which the stone is lodged. 4,6 Edema, urinary tract infection, spasm and ureteral peristalsis can be modified by appropriate medical therapy. If the friction between the intraureteral wall and the stone decreases, ureteral relaxation occurs and promotes stone passage at the site of obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have found positive results in accelerating lower ureteral stone passage using α-adrenergic antagonists on the basis that α1-adrenergic receptors play an important physiological role in distal ureteral passage. 1,6 To our knowledge, there are no comparative papers that investigate the effectiveness of different expulsive medical therapies (EMT). We carry out a comparative study to evaluate the safety and efficacy of α-adrenergic antagonists for the ureteral stone passage.…”

Section: Introductionmentioning

confidence: 99%

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Usefulness of adjunctive alpha1-adrenergic antagonists, after single extracorporeal shock wave lithotripsy session, in ureteral stone expulsion.

Janane¹,

Hamdoun

Hajji

et al. 2014

CUAJ

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Cite as: Can Urol Assoc J 2014;8(1-2):e8-11. http://dx.doi.org/10.5489/cuaj.1261 Published online January 14, 2014. AbstractIntroduction: We evaluate the efficiency of α-adrenergic antagonists on stone clearance after extracorporeal shock wave lithotripsy (ESWL) in patients with lower ureteral stones. Methods: A total of 356 patients with solitary lower ureteral stones who underwent single ESWL sessions were divided into 2 groups. Group 1 received our standard medical therapy, and Group 2 was treated with 0.4 mg/day tamsulosin for a maximum of 2 weeks. All patients were re-evaluated with plain film radiography and ultrasound each week during the treatment period. A computed tomography scan was systematically performed 3 months after ESWL. Results: In total, 82 of the 170 patients in Group 1 (48.2%) and 144 of the 186 patients in Group 2 (77.4%) (p = 0.002) were stonefree. Among the patients with stones 10 to 15 mm in diameter, the stone-free rate was 38.4% in Group 1 and 77.1% in Group 2 (p = 0.003). Average stone expulsion time was 10.6 days and 8.4 days in Groups 1 and 2, respectively. Ureteral colic occurred in 40 patients (23.5%) in Group 1, but only in 10 patients (5.3%) in Group 2 (p = 0.043). The only side effect of tamsulosin was slight dizziness in 5 of the 186 patients in Group 2 (2.6%). Conclusion: Adjunctive therapy with α1-adrenergic antagonists after ESWL is more efficient than, and equally as safe as, lithotripsy alone to manage patients with lower ureteral stones. The adding of α-blockers is more reliable and helpful for stones with a large dimension, and can also decrease stone elimination time and episodes of ureteral colic.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Usefulness of adjunctive alpha1-adrenergic antagonists, after single extracorporeal shock wave lithotripsy session, in ureteral stone expulsion.

Janane¹,

Hamdoun

Hajji

et al. 2014

CUAJ

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“…A sample size of 58 patients was calculated using comparing two proportion formulas. It was estimated to yield 80% power (type II or beta error of 0.20%) to detect a difference of 20% or more between two groups (70% expulsion rate in tamsulosin group (1)(2)(3)(4)(5) and 90% in tamsulosin plus lithorex -B group), allowing 5% of type I error. Totally, 64 patients were enrolled in the study.…”

Section: Methodsmentioning

confidence: 99%

“…The incidence of urolithiasis is higher in the Middle East, western India and southern USA (1). In Europe and north America, life time risk of developing urinary tract stones is estimated 5%-10% (5).…”

Section: Introductionmentioning

confidence: 99%

“…The standard and first choice of treatment for renal calculi 6-20 mm is extracorporeal shock-wave lithotripsy (SWL) with a reported stone free rate ranged from 66% to 99% for kidney stones depends on stone size, location and anatomy of renal collecting system (3,5). In the last decades, medical expulsive therapy (MET) has become an accepted modality of treatment (1,3) following SWL that potentially decreases the costs of treatment (5) through facilitating stone passage and decreasing morbidity (6).…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of tamsulosin versus tamsulosin plus lithorex-B as medical expulsive therapy following extracorporeal shock-wave lithotripsy of renal and upper ureteric stones; a randomized clinical trial

Mehrabi¹,

Manzouri²,

Kohzadi³

et al. 2017

J Nephropharmacol

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Implication for health policy/practice/research/medical education:Further studies are necessary to provide comparison between tamsulosin and lithorex-B in separate groups for deciding about treatment with lithorex-B.Please cite this paper as: Mehrabi S, Manzouri L, Kohzadi A Mehrabi F. Efficacy of tamsulosin versus tamsulosin plus lithorex-B as medical expulsive therapy following extracorporeal shock-wave lithotripsy of renal and upper ureteric stones; a randomized clinical trial.Introduction: Urolithiasis is one of the most common disorders of urinary system. Objectives: To compare the efficacy and safety of tamsulosin versus tamsulosin plus lithorex-B. Patients and Methods:This study was an open-label, randomized, controlled trial conducted in Yasuj University of Medical Sciences, Iran in 2014 to 2015. After taking informed consent, a total of 64 patients aged 18 years and over, presenting with renal or upper ureteral stones up to 20 mm in diameter were enrolled in this study. After extracorporeal shock-wave lithotripsy (SWL), patients were randomly assigned to group A (n = 32) received tamsulosin 0.4 mg and group B (n = 32) received tamsulosin 0.4 mg plus lithorex-B 400 mg orally at bed time daily for 2 weeks. Finally, patients were assessed by KUB and sonography. The stone passage rate, drug adverse effects and pain score were evaluated. All data were analyzed using SPSS 21. Results: There were no significant differences between group A and B regarding stone expulsion rates (40.6% vs 43.7%, P = 0.83), adverse effects (34.4% vs 40.6%, P = 0.79) and mean score of pain (4.31 ± 2.02 vs 5 ± 2.01, P = 0.17) after 2 weeks follow up. Primary stone size was the predicting factor of stone passage (β = -0.42, P = 0.005, Exp (β) = 0.65, CI 95%, Exp (β): 0.48-0.88). Conclusion: Tamsulosin plus lithorex-B is safe and well tolerated with no extra benefit regarding the expulsion rate in 2 weeks follow up. Hence, the necessity of conducting a trial with a longer follow up period providing comparison between tamsulosin and lithorex-B in separate group is felt.

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Alpha-blockers after shock wave lithotripsy for renal or ureteral stones in adults

Oestreich

Vernooij

Sathianathen

et al. 2020

Cochrane Database of Systematic Reviews

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Efficacy of Tamsulosin Oral Controlled Absorption System After Extracorporeal Shock Wave Lithotripsy to Treat Urolithiasis

Cited by 21 publications

References 17 publications

Usefulness of adjunctive alpha1-adrenergic antagonists, after single extracorporeal shock wave lithotripsy session, in ureteral stone expulsion.

Usefulness of adjunctive alpha1-adrenergic antagonists, after single extracorporeal shock wave lithotripsy session, in ureteral stone expulsion.

Efficacy of tamsulosin versus tamsulosin plus lithorex-B as medical expulsive therapy following extracorporeal shock-wave lithotripsy of renal and upper ureteric stones; a randomized clinical trial

Alpha-blockers after shock wave lithotripsy for renal or ureteral stones in adults

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