2021
DOI: 10.1371/journal.pntd.0009822
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Efficacy of targeted indoor residual spraying with the pyrrole insecticide chlorfenapyr against pyrethroid-resistant Aedes aegypti

Abstract: Background There is an increased need to mitigate the emergence of insecticide resistance and incorporate new formulations and modes of application to control the urban vector Aedes aegypti. Most research and development of insecticide formulations for the control of Ae. aegypti has focused on their peridomestic use as truck-mounted ULV-sprays or thermal fogs despite the widespread knowledge that most resting Ae. aegypti are found indoors. A recent modification of indoor residual spraying (IRS), termed targete… Show more

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Cited by 16 publications
(20 citation statements)
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“…Conversely, in both the West African hut and I-ACT, mosquitoes cannot exit and are therefore more likely to make repeated contacts with the nets and sleeping humans. Hut design clearly influences both 72-h mosquito mortality and blood-feeding endpoints as seen in this study and others for Anopheles [ 34 , 43 , 44 ] and Aedes [ 46 ]. However, when considering the odds ratios, it was possible to detect differences between products with increased bioefficacy of Interceptor ® G2 compared to Interceptor ® in all hut designs, the tunnel test and the I-ACT, underlining the importance of comparing between products using well-powered studies with a rationale for the margins of acceptable difference between products [ 47 ].…”
Section: Discussionmentioning
confidence: 54%
“…Conversely, in both the West African hut and I-ACT, mosquitoes cannot exit and are therefore more likely to make repeated contacts with the nets and sleeping humans. Hut design clearly influences both 72-h mosquito mortality and blood-feeding endpoints as seen in this study and others for Anopheles [ 34 , 43 , 44 ] and Aedes [ 46 ]. However, when considering the odds ratios, it was possible to detect differences between products with increased bioefficacy of Interceptor ® G2 compared to Interceptor ® in all hut designs, the tunnel test and the I-ACT, underlining the importance of comparing between products using well-powered studies with a rationale for the margins of acceptable difference between products [ 47 ].…”
Section: Discussionmentioning
confidence: 54%
“…Clothianidin targets the nicotinic acetylcholine receptor (nAChR) in the insect central nervous system 50 , leading to a delayed effect on the mortality of mosquitoes. As seen with other insecticide, chlorfenapyr 51 , clothianidin increases its efficacy when mosquitoes are free-flying.…”
Section: Discussionmentioning
confidence: 98%
“…Clothianidin targets the nicotinic acetylcholine receptor (nAChR) in the insect central nervous system 50 , leading to a delayed effect on the mortality of mosquitoes. As seen with other insecticide, chlorfenapyr 51 , clothianidin increases its efficacy when mosquitoes are free-flying. www.nature.com/scientificreports/ A recent study, conducted in towns surrounding Merida, estimated a weekly cost of releasing Wolbachiacarrying male Ae.…”
Section: Discussionmentioning
confidence: 98%
“…The mosquitoes originated from a pyrethroid‐resistant population from Merida (Juan Pablo strain, from F4 generation) used for resistance evolution and operational studies 21 kept at the insectary of Unidad Colaborativa para Bioensayos Entomologicos of the Universidad Autonoma de Yucatan (UCBE‐UADY). The strain undergoes mixing with field populations every 6 months and undergoes routine Centers for Disease Control and Prevention (CDC) cone bioassays to quantify levels of phenotypic resistance to the four major groups of insecticides (pyrethroid, carbamate, organophosphate, organochlorine).…”
Section: Methodsmentioning
confidence: 99%
“…Methods were similar to those previously described by Che‐Mendoza et al 21 . Briefly, three experimental houses (typical middle‐ to low‐income housing) were equally furnished and double‐screened with mosquito mesh on outdoor and interior doors and windows to impede mosquito entry/exit (see Dunbar et al 20 .…”
Section: Methodsmentioning
confidence: 99%