Efficacy of the barley-based remedy, a Persian medicine formula, in coronavirus disease 2019 (COVID-19) hospitalized patients: An open-labeled randomized controlled trial

Hasheminasab, Fatemeh Sadat; Azimi, Maryam; Khodadoost, Mahmood; Choubani, Bahram; Shakeri, Nezhat; Ghasemi, Saeedeh; Farokhi, Azam; Mokaberinajad, Roshanak

doi:10.1016/j.aimed.2022.04.001

Cited by 9 publications

(4 citation statements)

References 35 publications

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“… Fazlju, et al (2022) 38 Iran I: Polium: 267 (140/ 127) - Hyssop: 231 (112/ 119) C: 252 (137/115) I: - Polium: 36.4 (17,4) - Hyssop: 36.2 (19,6) C: 37.2 (18,1) Polium: 18% Hyssop: 11.3% N/A N/A N/A N/A N/A Placebo Hyssop and Polyum as much as 5 (for under 12 years) or 10 cc (for over 12 years) per day after breakfast for 20 days POLIUM: Teucrium polium L.; Cuscuta epithymum Murr;Cichorium intybus L Hyssop: Hyssopus officinalis L.; Echium amoenum Fisch and C.A. Mey; Glycyrrhiza glabra L. Hasheminasab, et al (2022) 37 Iran I: 35 (14/ 18) C: 35 (17/ 15) I: 51.49 (11,61) C: 53.28 (13,22) N/A N/A N/A N/A N/A N/A Conventional therapy Barley-based remedy for 5 days H. vulgare; Z. Jujuba; C. Myxa Varnasseri M, et al (2022) 33 Iran I: 30 (12/ 18) C: 30 (17/ 13) I: 47.87 (14.31) C: 44.27 (11.20) N/A N/A N/A N/A N/A 40 200 mg hydroxychloroquine sulfate; Lopinavir/ritonavir (Kaletra) 2g Amla sachets every 12 hours for 10 days Phyllanthus Emblica Asadirad A, et al (2021) 36 Iran I: 30 (24/6) C: 30 (24/6) I: 56 (14.02) C: 50.2 (12.01) N/A N/A N/A N/A …”

Section: Resultsmentioning

confidence: 99%

The Efficacy of Herbs as Complementary and Alternative Therapy in Recovery and Clinical Outcome Among People with COVID-19: A Systematic Review, Meta-Analysis, and Meta-Regression

Komariah¹,

Amirah²,

Maulana³

et al. 2023

TCRM

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Background The COVID-19 pandemic continues, and this condition has caused many cases in various countries around the world, resulting in more than 6 million deaths worldwide. Herbal medicines can act as immunomodulators, anti-inflammatories, antioxidants, antimicrobials, and others depending on the type and content of the herbs used. Previous studies have shown that several types of herbs, such as Echinacea purpurea, Curcumin or Turmeric, Nigella sativa, and Zingiber officinale , have proven their effectiveness as herbal plants for COVID-19. Methods We conducted a comprehensive literature search through five databases, namely, PubMed, Scopus, Embase, Wiley, and ProQuest to assess the efficacy of phytopharmaceuticals until July 12, 2022. We used the Cochrane RoB 2.0 for the quality assessment of the study. Results Phytopharmaceuticals significantly improved patients’ recovery rate (OR = 3.54; p < 0.00001) and reduced deaths (OR = 0.24; p < 0.0001) compared to the control group. Phytopharmaceuticals also performed as a protective factor for COVID-19 clinical symptoms, such as dyspnea (OR = 0.42; p < 0.05) and myalgia (OR = 0.31; p = 0.02) compared to the control group. However, there is no statistically significant effect on cough (OR = 0.76; p = 0.61) and fever (OR = 0.60; p < 0.20). The results were not affected by patients’ covariates [hypertension, diabetes mellitus, and cardiovascular diseases (meta-regression p > 0.05)]. Conclusion Herbal medicine has the potential as an adjuvant therapy in the management of COVID-19.

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Section: Resultsmentioning

confidence: 99%

The Efficacy of Herbs as Complementary and Alternative Therapy in Recovery and Clinical Outcome Among People with COVID-19: A Systematic Review, Meta-Analysis, and Meta-Regression

Komariah¹,

Amirah²,

Maulana³

et al. 2023

TCRM

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“…If the patient was discharged earlier than five days, the outcome was assessed by the researcher. In this regard, a more complete explanation was published by Hashemi Nasab et al (10).…”

Section: Methodsmentioning

confidence: 96%

Evaluating the Effect of a Natural Formulation Based on Hordeum Vulgare on the Recovery of COVID-19 Patients: Application of Survival Analysis in a Clinical Trial

Amini

Shakeri

Amini

et al. 2022

Ann Mil Health Sci Res

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Background: Coronavirus disease 2019 (COVID-19) has affected the lives of people all over the world. Although researchers are working to manage and minimize the impact of the current COVID-19 pandemic, no definitive treatment method has been identified so far. The present clinical trial aimed to evaluate the survival of two groups of patients with COVID-19. Methods: The statistical population of this prospective clinical trial included 70 patients hospitalized in the Mofatteh Hospital in Varamin, Iran, from 13 May to 10 July 2020. The intervention and control groups were compared using the Kaplan-Meier method and log-rank test. Results: Patients in the intervention group had a higher survival rate than the control group. Conclusion: Hordeum vulgare increased the survival of patients.

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“…We report for the first time the role of barley malt in COVID-19 prescribing in eight provinces in China and barley grass powder has a certain effect on COVID-19 treatment [52]; Barley-based remedy could significantly enhance the blood oxygen saturation and reduce fatigue in COVID-19 patients [53].The ricin-based peptide from barley was able to inhibit Mpro in vitro with an IC50 of 0.52 nM, and its low and no cytotoxicity upto 50 μM suggested its therapeutic potential against SARS-CoV-2.…”

Section: Control Covid-19mentioning

confidence: 99%

Actional Mechanism of Functional Ingredients in Beer and Barley for Human Health

Zeng,

Ahmed,

et al. 2024

Preprint

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Nutrition therapy is the best solution to human chronic diseases, especially beer and barley which play an important role in human health and civilization. We demonstrated the actional mechanism of functional ingredients in beer and barley to combat chronic diseases, based on PubMed, google, CNKI, and ISI Web of Science databases from 1997 to 2024. Beer is rich in functional ingredients that is a complex of barley malt and hops; the health effect of beer against 26 chronic diseases is highly similar to that of barley, due to molecular mechanism of polyphenols (phenolic acids, flavonoids), melatonin, minerals, bitter acids, vitamins, and peptides. The ancient German Beer Purity Law provides much scientific basis today, especially indirectly supporting the human one cell disease theory. Low purine beer can be produced by enzymatic and biological degradation and adsorption of purines as well as dandelion addition. Functional beer with low purine and high active ingredients made from Beer Purity and barley malt as well as functional foods addition will be the key and important development direction, such as ginger beer and ginseng beer, especially coix-lily beer at the ancestors ca. 9000 years ago. This review paper not only reveals the actional mechanism of beer overcoming human chronic diseases, but also provides scientific basis for the development of functional beer for the prevention and treatment of human chronic diseases.

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Efficacy of the barley-based remedy, a Persian medicine formula, in coronavirus disease 2019 (COVID-19) hospitalized patients: An open-labeled randomized controlled trial

Cited by 9 publications

References 35 publications

The Efficacy of Herbs as Complementary and Alternative Therapy in Recovery and Clinical Outcome Among People with COVID-19: A Systematic Review, Meta-Analysis, and Meta-Regression

The Efficacy of Herbs as Complementary and Alternative Therapy in Recovery and Clinical Outcome Among People with COVID-19: A Systematic Review, Meta-Analysis, and Meta-Regression

Evaluating the Effect of a Natural Formulation Based on Hordeum Vulgare on the Recovery of COVID-19 Patients: Application of Survival Analysis in a Clinical Trial

Actional Mechanism of Functional Ingredients in Beer and Barley for Human Health

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