Efficacy of the FDA nozzle benchmark and the lattice Boltzmann method for the analysis of biomedical flows in transitional regime

Jain, Kartik

doi:10.1007/s11517-020-02188-8

Cited by 18 publications

(26 citation statements)

References 31 publications

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“…Thus, if fluctuations occur in localized parts of the domain during parts of the cycle, we term the flow transitional. This is in accordance with several such studies in this direction 36,33,38,21,20 . The onset of a fully developed turbulence is not pursued and the focus is on exploring the critical Re at which the flow leaves a laminar regime for a particular degree of stenosis, and a specific pulsation frequency (Womersley number).…”

Section: Introductionsupporting

confidence: 93%

“…Several efforts in the direction of validation have been placed, see for example a comparison against experiments reported in Johannink et al 23 . A comprehensive validation for the simulation of physiologic flows in transitional and turbulent regime was conducted using the benchmark set out by the US Food and Drug Administration (FDA) 20 . For each new biomedical application, comparisons against in vitro and in vivo measurements are performed during the continuous use and development of Musubi.…”

Section: Direct Numerical Simulationmentioning

confidence: 99%

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The effect of varying degrees of stenosis on transition to turbulence in oscillatory flows

Jain¹

2022

Preprint

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Many complications in physiology are associated with a deviation in flow in arteries due to a stenosis. The presence of stenosis may transition the flow to weak turbulence. The degree of stenosis as well as its configuration whether symmetric or non-symmetric to the parent artery influences whether the flow would stay laminar or transition to turbulence. Plenty of research efforts focus on investigating the role of varying degrees of stenosis in the onset of turbulence under steady and pulsatile flow conditions. None of the studies, however, have focused on investigating this under oscillatory flow conditions as flow reversal is a major occurrence in a number of physiologic flows, and is of particular relevance in cerebrospinal fluid (CSF) flow research. Following up on the previous work in which a 75% stenosis was studied, this contribution is a detailed investigation of the role of degrees of stenosis on transition in an oscillatory flow. A cylindrical pipe with 25%, 50% and 60% reductions in area in axisymmetric and eccentric configurations is studied for transition with 3 different pulsation frequencies of a purely oscillatory flow. Cycle averaged Reynolds numbers between 1800 and 2100 in steps of 100 are studied for each configuration resulting in 72 simulations each conducted on 76 800 CPU cores of a modern supercomputer. It is found that a higher degree of stenosis and eccentricity causes earlier transition to turbulence in oscillatory flow. The results further demonstrate that a higher frequency of oscillation results in larger hydrodynamic instability in the flow, which is more prominent in smaller degrees of stenosis 1 .

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Section: Introductionsupporting

confidence: 93%

Section: Direct Numerical Simulationmentioning

confidence: 99%

The effect of varying degrees of stenosis on transition to turbulence in oscillatory flows

Jain¹

2022

Preprint

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“…The simulations were executed for 2 s and the characteristics were analyzed at t = 2s. Based on a previous comprehensive mesh convergence study [7,23], the meshes were discretized with a spatial and temporal resolution of Δx = 32µm and Δt = 1µs respectively. This resulted in mesh sizes between 25 million and 230 million cells.…”

Section: Methodsmentioning

confidence: 99%

“…The Lattice Boltzmann flow solver Musubi [24] was used for simulations. In order to ensure the quality of the DNS, we computed the Kolmogorov microscales using the fluctuating component of the strain rate as previously described in Junk and Yang [7,23]. A comparison of the employed resolutions against the computed Kolmogorov scales ensured the quality of the resolutions chosen for the DNS.…”

Section: Methodsmentioning

confidence: 99%

CADA Challenge: Rupture Risk Assessment Using Computational Fluid Dynamics

Jain

2021

Cerebral Aneurysm Detection

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The phase 3 of the cerebral aneurysm detection and analysis (CADA) challenge involved rupture risk estimation of intracranial aneurysms using computational methods. In this work we performed computational fluid dynamics (CFD) on a subset of aneurysm cases provided by the challenge committee. A large number of aneurysm cases were available, CFD analysis using the lattice Boltzmann method (LBM) were performed on 18 of them. These 18 aneurysms were chosen on the basis of most distinct shape, size and location. Direct numerical simulations were performed to identify wall shear stress and pressure, and associate these hemodynamic quantities with the rupture status of aneurysms and eventually extrapolate those findings to other aneurysms. The results of the DNS may serve as inputs for data driven methods to identify qualitative maps of hemodynamic quantities in aneurysms. In this article we report the results of CFD and discuss hypotheses associating the flow characteristics with the rupture risk of aneurysms.

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“…But they have their advantages and disadvantages. Many new scientific results were obtained by numerical simulations using various methods and techniques [18][19][20][21][22][23][24] that require experimental confirmation and verification. Therefore, an urgent task of modern scientific hemodynamic and biomechanic studies is conducting experimental studies with high-precision and miniature measuring instruments [25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Statistical Characteristics of Flow Field through Open and Semi-Closed Bileaflet Mechanical Heart Valve

et al. 2020

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The formation of thrombi on the streamlined surface of the bileaflet mechanical heart valves is one of the main disadvantages of such valves. Thrombi block the valve leaflets and disrupt the cardiovascular system. Diagnosis of thrombosis of the bileaflet mechanical heart valves is relevant and requires the creation of effective diagnostic tools. Hydroacoustic registration of the heart noise is one of the methods for diagnosing the operation of a mechanical heart valve. The purpose of the research is to determine the statistical characteristics of the vortex and jet flow through the open and semi-closed bileaflet mechanical heart valve, to identify hydroacoustic differences and diagnostic signs to determine the operating conditions of the valve. Experimental studies were conducted in laboratory conditions on a model of the left atrium and left ventricle of the heart between which there was the bileaflet mechanical heart valve. Hydrodynamic noise was recorded by miniature pressure sensors, which were located downstream of the valve. The vortex and jet flow behind the prosthetic heart valve were non-linear, random processes and were analyzed using the methods of mathematical statistics and probability theory. The integral and spectral characteristics of the pressure field were obtained and the differences in the noise levels and their spectral components near the central and side jets for the open and semi-closed mitral valve were established. It was shown that hydroacoustic measurements could be an effective basis for developing diagnostic equipment for monitoring the bileaflet mechanical heart valve operation. Doi: 10.28991/SciMedJ-2020-0204-1 Full Text: PDF

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Efficacy of the FDA nozzle benchmark and the lattice Boltzmann method for the analysis of biomedical flows in transitional regime

Cited by 18 publications

References 31 publications

The effect of varying degrees of stenosis on transition to turbulence in oscillatory flows

The effect of varying degrees of stenosis on transition to turbulence in oscillatory flows

CADA Challenge: Rupture Risk Assessment Using Computational Fluid Dynamics

Statistical Characteristics of Flow Field through Open and Semi-Closed Bileaflet Mechanical Heart Valve

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