Efficacy of the red blood cell distribution width for predicting the prognosis of Bell palsy: a pilot study

Horibe, Yuichiro; Tanigawa, Tohru; Shibata, Rei; Nonoyama, Hiroshi; Kano, Fumiya; Yamaguchi, Satoshi; Murotani, Kenta; Ogawa, T.

doi:10.1007/s00405-016-4445-z

Cited by 13 publications

(17 citation statements)

References 20 publications

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“…So, they suggested determining neutrophil-to-lymphocyte ratio values as an indicator for predicting prognosis in patients with Bell’s palsy. 14,15 In contrast to these studies, Horibe et al 16 found that neutrophil-to-lymphocyte ratio was not a statistically significant marker for prognosis of Bell’s palsy; instead, red blood cell distribution width was significantly higher in unrecovered adult patients with Bell’s palsy. The study by Eryilmaz et al, 13 which is the only one evaluating neutrophil-to-lymphocyte ratios in pediatric patients with Bell’s palsy, found high neutrophil-to-lymphocyte ratios in patients when compared to the control group, which supported the inflammatory etiology of the disease.…”

Section: Discussionmentioning

confidence: 91%

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Prognostic Factors Associated With Recovery in Children With Bell’s Palsy

Karatoprak

Yılmaz

2019

J Child Neurol

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Objectives: The aim of the study was to determine the prognosis of children with Bell’s palsy and analyze the prognostic factors affecting early recovery. Methods: The records of children with a diagnosis of Bell’s palsy were retrospectively analyzed. Demographic and clinical features including age, gender, House-Brackmann Facial Nerve Grading System House-Brackmann Grading Scale (HBGS) grade at admission and follow-up, and the dosage and onset of steroid treatment were reviewed. Laboratory findings such as red blood cell distribution width and neutrophil-to-lymphocyte ratio were noted. The patients who were recovered within the first month (early recovery) were compared with the patients who were recovered after first month (late recovery) in terms of demographic, clinical characteristics, laboratory findings and treatment modalities in order to determine the risk factors affecting early recovery. Results: A total of 102 children (65 girls and 37 boys) with a mean age of 10.37 ± 4.2 years were included in the study. The complete recovery was detected in 101 children (%99) with Bell’s palsy. Statistically significant difference was found in terms of dosage and time of onset of steroid treatment ( P = .04, P = .035, respectively) and House-Brackmann Facial Nerve Grading System grade on the 10th day ( P = .001) between the early and late recovery groups. Conclusion: The prognosis of Bell’s palsy in children was very good. The prognostic factors affecting the early recovery were being House-Brackmann Facial Nerve Grading System grade 2 or 3 on the 10th day and receiving steroid treatment in the first 24 hours. Neutrophil-to-lymphocyte ratio and red blood cell distribution width were not found to be predictive factors for early recovery.

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Section: Discussionmentioning

confidence: 91%

“…14,15 Red blood cell distribution width, which shows the size and volume of the circulating erythrocytes, is also considered to be associated with inflammation. Horibe et al 16 found that red blood cell distribution width was associated with recovery from Bell’s palsy in adults.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Factors Associated With Recovery in Children With Bell’s Palsy

Karatoprak

Yılmaz

2019

J Child Neurol

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“…The authors proposed the RDW could be a useful prognostic factor in patients with BP. 29 In contrast, RDW values were no significantly higher in patients with BP in another report. 23 Our results also demonstrated that there were no significant differences in MPV or RDW, which suggests that MPV and RDW are not meaningful parameters in children with BP.…”

Section: Discussionmentioning

confidence: 79%

Predictive Values of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Other Prognostic Factors in Pediatric Patients With Bell’s Palsy

Kim

et al. 2020

Ear Nose Throat J

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Background and Objectives: Bell’s palsy (BP) is the most frequent cause of unilateral facial paralysis, and inflammation is believed to play an important role in pathogenesis. Due to its rarity, however, no consensus has been reached regarding optimum treatment or factors affecting prognosis. In the present study, treatment outcomes and prognostic factors of BP were investigated in pediatric patients who underwent steroid therapy. The goal was to investigate the relationship between BP and inflammation using multiple inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and red cell distribution width (RDW). Materials and Methods: In all, 54 patients diagnosed with BP and 39 healthy randomly selected controls were enrolled in this retrospective study. Demographic characteristics and complete blood cell count test results were compared. In addition, prognostic factors were sought by dividing the 54 patients with BP into 2 groups according to the House-Brackmann grading system: low grade BP (grades II and III) and high grade BP (grades IV and V). Serum samples were analyzed retrospectively on initial presentation and 6 months after the symptom begins. Meaningful hematological parameters include NLR, PLR, MPV, and RDW. Results: The NLR values in the BP group were significantly higher than in the control group. The NLR value in the 2 groups of patients with BP differed significantly. The mean PLR value in the BP group was higher than in the control group; however, there were no significant differences between the low-grade and high-grade BP groups nor were there any statically significant differences in the other characteristics. Conclusion: The NLR and PLR values are readily accessible parameters that may be useful prognostic markers in pediatric patients with BP. Further studies are required to confirm these results and their utility in predicting prognosis and treating pediatric patients with BP.

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“…Recent literature focus on the prognostic value of parameters indicating systemic inflammation for BP (22)(23)(24)(25)(26)(27). The presence of systemic inflammatory response can be indicated by leukocytes, neutrophils, lymphocytes, platelets and acute-phase proteins in blood tests (28).…”

Section: Introductionmentioning

confidence: 99%

Effect of Diabetes and Systemic Inflammation Parameters on the Prognosis of Bell’s Palsy

Şencan

Comert

Şimşek

et al. 2021

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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Objective: This study aimed to evaluate the prognostic importance of diabetes mellitus, hematologic and biochemical test findings including neutrophil-to-lymphocyte ratio, plateletto-lymphocyte ratio, systemic inflammation response index and triglyceride-glucose index in patients with Bell's palsy and to compare these results with healthy subjects. Material and Methods:The study included 75 patients with incomplete Bell's palsy. and 24 healthy subjects as the control group. Patients were divided into two groups as diabetes mellitus and non-diabetes mellitus patients. Complete blood count, biochemical tests including glucose, liver and renal function tests and blood lipid profile were analyzed from all the subjects and neutrophil-tolymphocyte ratio, platelet-to-lymphocyte ratio, systemic inflammation response index and triglyceride-glucose index values were calculated from these results.Results: Neutrophil-to-lymphocyte ratio and systemic inflammation response index values were higher in patients with Bell's palsy when compared with the control group. Triglycerideglucose index was positively correlated with recovery time in all patients and the diabetes mellitus group. It was also positively correlated with prognosis in non-diabetes mellitus patients. High neutrophil-to-lymphocyte ratio was predictive for delayed recovery time only in non-diabetes mellitus patients. Conclusion:Our results indicated that diabetes mellitus didn't influence severity, recovery time and prognosis of Bell's palsy. High triglyceride levels and triglyceride-glucose index values were associated with long recovery time in patients with Bell's palsy. For both diabetes mellitus and non-diabetes mellitus patients, House-Brackmann facial nerve grading scale-initial was the best parameter to predict the prognosis. Neutrophil-tolymphocyte ratio and systemic inflammation response index values were significantly higher in patients with Bell's palsy. Amaç: Bell palsili hastalarda, diyabetin prognostik önemini, nötrofil-lenfosit oranı, trombosit-lenfosit oranı, sistemik inflamasyon yanıt indeksi dahil hematolojik ve biyokimyasal test bulgularını değerlendirmek, ayrıca Bell palsili hastalarda trigliserid-glikoz indeksini değerlendirmek ve bu sonuçları sağlıklı deneklerle karşılaştırmaktır.Gereç ve Yöntemler: Çalışmaya, Bell palsisi komplet olmayan 75 hasta ve kontrol grubu olarak 24 sağlıklı birey dahil edildi. Hastalar diyabet olan ve diyabet olmayan olarak iki gruba ayrıldı. Tüm deneklerden tam kan sayımı, glikoz, karaciğer ve böbrek fonksiyon testleri gibi biyokimyasal testler ve kan lipid profili analiz edildi ve bu sonuçlardan nötrofil-lenfosit oranı, trombosit-lenfosit oranı, sistemik inflamasyon yanıt indeksi ve trigliserid-glikoz indeksi değerleri hesaplandı.Bulgular: Nötrofil-lenfosit oranı ve sistemik inflamasyon yanıt indeksi değerleri Bell palsili hastalarda kontrol grubuna göre daha yüksekti. Trigliserid-glikoz indeksi, tüm hastalarda ve diyabet grubunda iyileşme süresi ile pozitif korelasyon gösterdi. Trigliserid-glikoz indeksi ayrıca di...

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Efficacy of the red blood cell distribution width for predicting the prognosis of Bell palsy: a pilot study

Cited by 13 publications

References 20 publications

Prognostic Factors Associated With Recovery in Children With Bell’s Palsy

Prognostic Factors Associated With Recovery in Children With Bell’s Palsy

Predictive Values of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Other Prognostic Factors in Pediatric Patients With Bell’s Palsy

Effect of Diabetes and Systemic Inflammation Parameters on the Prognosis of Bell’s Palsy

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