Efficacy of the triazole D0870 in a murine model of systemic histoplasmosis

Abstract

The efficacy of D0870 was studied in a murine model of systemic histoplasmosis and was compared with that of fluconazole. All regimens of D0870 (1 or 10 mg/kg of body weight given daily or 1, 10, or 100 mg/kg given every other day) and 100 mg of fluconazole per kg given daily provided complete protection from lethality. Comparison of the number of viable Histoplasma capsulatum yeasts remaining in the spleen or liver indicated that D0870 was superior to fluconazole in clearing and curing infection. D0870 was 10- to 100-fold more efficacious than fluconazole in the treatment of experimental histoplasmosis.

The Cellular Responses Induced by the Capsular Polysaccharide of Cryptococcus neoformans Differ Depending on the Presence or Absence of Specific Protective Antibodies

“…One can argue that the capacity of capsular material to dampen specific Th1 responses is in part derived from IL-12 suppression, but the mechanism is not well defined. A possible monocytes [74]. In particular, different effects of two Fcγ RII isoforms, Fcγ RIIa and Fcγ RΙΙb, have been described and Fcγ RIIa has been regarded as an activator of multiple intracellular pathways [75].…”