Antifungal therapy, an everlasting battle

Allylamine Type Xanthone Antimycotics

“…Finally, we wish to point out that most antifungal agents are inactive towards the infection caused by Cryptococcus neoformans (responsible amongst other things, for pneumopathic infections and meningitis) [5] , so that compound 4d may be regarded as a new model structure for further research in the area of O-heterocycles.…”

Identification of a novel antifungal nonapeptide generated by combinatorial approach

“…Enhancement of efficacy by the combined use of antibiotic agent is also an attractive strategy. Since the last decade many studies have been conducted on the interaction of drugs available in the market [1,8,[19][20][21]. Besides these, there are some reports available regarding interaction between N-terminal peptide of human lactoferrin with fluconazole [4,22] and antimicrobial synergism between two peptides magainin 2 and PGLa, discovered in the skin of the African clawed frog [23].…”

“…Antifungal therapy offers a unique challenge, primarily because fungi are eukaryotic organisms that share a common line with their mammalian host in terms of replication and metabolism [1], and secondarily the fungus is well protected inside a chemically complex and physically tough cell wall, offering considerable chemical and stearic hindrance to the drug molecule. Although only few fungi (Histoplasma, Coccidioides, Blastomyces and Paracoccidioides) are known to be potentially pathogenic [2], the commonest occurring infections (oral thrush, oesophageal and vulvo-vaginal thrush, etc.)…”

Antifungal activity of Swietenia mahogany on Candida albicans and Cryptococcus neoformans

“…This fact coupled with the resistance to antibiotics and with the toxicity during prolonged treatment with several antimicrobial drugs (Giordani et al, 2001) has been the reasons for an extended search for newer drugs to treat opportunistic microbial infections . Antifungal therapy offers a unique challenge, primarily because fungi are eukaryotic organisms that share a common line with their mammalian host in terms of replication and metabolism (Polak, 1998), and secondarily because the physically tough cell wall, offering considerable chemical fungus is well protected inside a chemically complex and and steric hindrance to the drug molecule. Although, only few fungi (Histoplasma, Coccidioides, Blastomyces and Paracoccidioides) are known to be potentially pathogenic (Rippon, 1982), the commonest occurring infections (oral thrush, oesophageal and vulvo-vaginal thrush, etc.)…”