Allylamine Type Xanthone Antimycotics

Abstract

A number of xanthone derivatives bearing the basic chain of naftifine and butenafine antimycotics in 1, 2, 3, and 4 nuclear positions are described. The in vitro antifungal activity against representative strains of molds and yeasts is reported. Only butenafine xanthone analogues show significant activity against, Cryptococcus neoformans, in particular the regioisomer 4d (1.5 μg/ml).

Antifungal Activity of Xanthones: Evaluation of their Effect on Ergosterol Biosynthesis by High-performance Liquid Chromatography

“…Concerning antifungal activity, investigations have been undertaken in the group of both synthetic (8,9) and naturally occurring xanthone derivatives. Consequently, in an attempt to search for naturally occurring antifungal compounds, a number of xanthones with clinical value against fungal infections, from higher plants (8,10–26) and microorganisms (27–34) including marine species (35,36), have been identified. These xanthones are mainly divided into four subclasses: simple oxygenated (8,15,17,25,26,35,36), prenylated (8,10–14,16–22,24,26), polycyclic (27–29), and dehydroxanthones (15,31–34) such as ergochromes and hemisecalonic acids.…”