Efficacy of topical silicone gel in scar management: A systematic review and meta‐analysis of randomised controlled trials

Wang, Fan; Li, Xiaoxue; Wang, Xiuyun; Jiang, Xian

doi:10.1111/iwj.13337

Cited by 27 publications

(20 citation statements)

References 30 publications

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“…12,14 Fortunately, silicone gel has been proven to be as effective as silicone sheets, allowing for easier and less obvious application. 15 This treatment can be used proactively, especially in those prone to hypertrophic scarring. 15 Botulinum toxin injections may also be utilized as a therapeutic or preventative strategy.…”

Section: Superficial Defects Hypertrophic Scarsmentioning

confidence: 99%

“…15 This treatment can be used proactively, especially in those prone to hypertrophic scarring. 15 Botulinum toxin injections may also be utilized as a therapeutic or preventative strategy. 12,16,17 In controlled prospective studies by Xiao et al and Elhefnawy, botulinum toxin injections into hypertrophic scars led to some level of scar improvement in 100% of their population.…”

Section: Superficial Defects Hypertrophic Scarsmentioning

confidence: 99%

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Revisional Techniques for Secondary Cleft Lip Deformities

et al. 2021

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Secondary deformities of repaired cleft lips are an unfortunate complication despite the meticulous approach of modern primary procedures. Most of these surgeries take place in the patient's early life and must be strategically planned to provide optimal cosmesis with minimal interventions. Depending on the level of severity, treatment of the secondary deformities ranges from noninvasive or minimally invasive techniques to complete revision cheiloplasty. Many novel topical, injectable, and laser therapies have allotted physicians more technical flexibility in treating superficial distortions. Nonetheless, surgical techniques such as diamond excision and adjacent tissue transfer remain popular and useful reconstructive modalities. Deformities involving the orbicularis oris must be completely taken down to allow full access to the muscle. Complete revision cheiloplasty requires recreation of the cleft defect and reconstruction similar to the primary repair. Due to the myriad of presentations of these secondary deformities, familiarity with the various treatments available is imperative for any cleft surgeon.

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Section: Superficial Defects Hypertrophic Scarsmentioning

confidence: 99%

Section: Superficial Defects Hypertrophic Scarsmentioning

confidence: 99%

Revisional Techniques for Secondary Cleft Lip Deformities

et al. 2021

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“…One similar RCT 25 reported that topical silicone gel plus herbal extract gel (Allium cepa, Centella asiatica, Aloe vera, and paper mulberry) had better vascularity and pigmentation than silicone gel. Although topical silicone gel beneficial for scar prevention has been concluded by two meta-analyses with weak evidence, 26,27 the performance of topical silicone gel and other non-silicone topical treatment is also similar. 27 Thus, OE in silicone gel seems an optimal choice for scar treatment, but still needs more studies to strength this evidence.…”

Section: Discussionmentioning

confidence: 99%

“…Although topical silicone gel beneficial for scar prevention has been concluded by two meta-analyses with weak evidence, 26,27 the performance of topical silicone gel and other non-silicone topical treatment is also similar. 27 Thus, OE in silicone gel seems an optimal choice for scar treatment, but still needs more studies to strength this evidence.…”

Section: Discussionmentioning

confidence: 99%

Onion extract gel is not better than other topical treatments in scar management: A meta‐analysis from randomised controlled trails

Yuan

Shen

Chen

et al. 2020

International Wound Journal

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To evaluate the efficacy and safety of onion extract (OE) gel on scar management, a systematic review was performed by searching Embase, PubMed, Medline, and the Cochrane Library databases, and a meta‐analysis was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement guidelines. Finally, 13 randomised controlled trails were enrolled for meta‐analysis. OE gel increased the total improvement scores assessed by investigators (P < .00001) and patients (P < .00001) than no treatment, but no differences were detected between OE gel and other commonly used topical treatments assessed by investigators (P = .56) and patients (P = .39). Moreover, OE in silicone gel increased the total improvement scores assessed by investigators (P < .00001) and patients (P = .0007) than other treatments. OE gel increased the incidence of total adverse effects compared with no treatment (P < .0001) and other treatments (P = .008) by a fixed‐effects model, and increased the incidence of dropping out caused by intolerance of treatments (P = .0002). OE gel not only has no superiority to commonly used topical treatments, but also has the potential to increase the incidence of adverse effects on scar management; OE in silicone gel might be the optimal topical choice for scar treatment; however, more evidences are needed to strength these conclusions.

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“…[3,4] The pathophysiology of hypertrophic scars and keloids is extremely complex, and the current therapies, such as topical formulations (silicone gel, flavonoids: onion extraction), laser treatment, corticosteroid injections and cryotherapy, are far from sufficient. [5,6] Some recent research has focused on the renin-angiotensin system (RAS) in the process of both wound healing and scar formation as a promising therapeutic target. [7] Here, we summarize and review the role of the RAS in scar formation as well as the application of these advances in the treatment of hypertrophic scars and keloids.…”

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confidence: 99%

The renin‐angiotensin system in cutaneous hypertrophic scar and keloid formation

Hedayatyanfard

Haddadi

Ziai

et al. 2020

Experimental Dermatology

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Deep cutaneous injuries such as burn injuries, physical trauma, surgical incisions, vaccinations, skin piercings and even insect bites occasionally produce hypertrophic scars or keloids. It has been estimated that over 100 million people annually suffer from scar-related complications that significantly impair their quality of life. [1,2] These issues include cosmetic problems, functional disabilities such as contractures, and symptoms including pruritus and pain. [1] Although the clinical course, physical appearance and pathophysiological features

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Efficacy of topical silicone gel in scar management: A systematic review and meta‐analysis of randomised controlled trials

Cited by 27 publications

References 30 publications

Revisional Techniques for Secondary Cleft Lip Deformities

Revisional Techniques for Secondary Cleft Lip Deformities

Onion extract gel is not better than other topical treatments in scar management: A meta‐analysis from randomised controlled trails

The renin‐angiotensin system in cutaneous hypertrophic scar and keloid formation

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