Efficacy of topical tacrolimus for oral lichen planus: real‐life experience in a retrospective cohort of patients with a review of the literature

Ribero, Simone; Stieger, Marco; Quaglino, Pietro; Hongang, T; Bornstein, Michael M.; Naldi, Luigi; Borradori, Luca

doi:10.1111/jdv.12758

Cited by 19 publications

(21 citation statements)

References 35 publications

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“…There have been safety concerns also related to TAC use in OLP, as a few case reports describe oral squamous cell carcinoma (SCC) developing after use of topical TAC (Becker et al , ; Mattsson et al , ; Morita et al , ). Although at the moment no firm evidence links topical TAC to oral SCC (Lopez‐Jornet et al , ; Ribero et al , ), it seems advisable that TAC is used for short periods only in cases not responsive to topical corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Topical tacrolimus, triamcinolone acetonide, and placebo in oral lichen planus: a pilot randomized controlled trial

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Topical tacrolimus, triamcinolone acetonide, and placebo in oral lichen planus: a pilot randomized controlled trial

et al. 2017

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“…In a retrospective study, topical tacrolimus therapy improved lesions in 15 of 16 women with vulvar lichen planus [16]. Nevertheless, in one study, only 7 patients of 21 who were diagnosed with oral lichen planus and treated with topical 0.1% tacrolimus twice daily showed complete response at month 6; although it was a retrospective study, the authors suggested that the efficacy of topical tacrolimus was overestimated in daily practice [17]. Al-Mutairi et al reported 13 patients with lichen planus pigmentosus who were treated with tacrolimus ointment and 7 (53.8%) of them showed prominent lightening of the pigmentation within 12 weeks [18].…”

Section: Discussionmentioning

confidence: 99%

Comparison of topical clobetasol propionate 0.05% and topical tacrolimus 0.1% in the treatment of cutaneous lichen planus

Özkur

Aksu²,

Gürel³

et al. 2019

pdia

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A b s t r a c t Introduction: The effectiveness of topical tacrolimus in the treatment of oral and genital lichen planus has been verified in many randomized studies; however, there are only few case reports in treatment of cutaneous lichen planus (CLP). Aim: We sought to compare the safety and efficacy of topical clobetasol propionate and tacrolimus ointment in the treatment of CLP. Material and methods: Retrospective analysis of patient files was performed. We enrolled patients who were diagnosed with CLP and treated with topical tacrolimus 0.1% or topical clobetasol propionate 0.05%. Visual Analogue Scale (VAS) scores of pigmentation and pruritus, clinical response, laboratory data and adverse effects were obtained from medical records. Results: A total of 27 patients were included in the clobetasol group and 23 patients in the tacrolimus group. Both groups showed an improvement in VAS scores regarding pruritus and pigmentation but a statistically significant difference was observed in the clobetasol group (p < 0.05). At week 12, a complete response was observed in 63% (n = 17) of the clobetasol and 26% (n = 6) of the tacrolimus group. Conclusions: In our study, both treatments were found effective in the treatment of CLP but clobetasol propionate was more effective. However tacrolimus may be preferred before topical corticosteroids for lesions on the face, neck, and intertriginous regions of the body, which are sensitive to the cutaneous adverse effects of topical corticosteroids. Our study may be one of the first studies to compare the effects of topical clobetasol and tacrolimus ointment in the management of CLP.

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“…Conversely, in the retrospective analysis conducted by Ribero et al, only 20% of patients achieved complete remission at 2 months, and 33% achieved remission after a 6month treatment with tacrolimus [45]. The average duration of tacrolimus treatment is 2 months, with four applications per day.…”

Section: Calcineurin Inhibitorsmentioning

confidence: 91%

“…Guo et al reported no adverse effects, while Resende et al described mild and transient side effects [43,44]. Ribero et al also found that patients reported a transitory burning sensation and altered taste sensation [45].…”

Section: Calcineurin Inhibitorsmentioning

confidence: 99%

Clinical Management of Oral Lichen Planus: A Systematic Review

Oberti

Lucchese

Petruzzi

et al. 2019

MRMC

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Aim: The clinical management of OLP represents a considerable challenge for the oral physician. The aim of this review is to assess the main intervention used in the management of OLP and the efficacy of every type of treatment. Materials and Methods:We searched and analyzed PubMed database for articles on OLP management. Only randomized controlled trials, comparing an active treatment with placebo, or between different active treatments, were considered in this systematic review. Only patients with symptomatic OLP were included and interventions of all types were considered (topical treatment, systemic drugs, non pharmacological intervention). Results:A total of 25 randomized controlled trials were examined and included in this review. Steroids are the most frequently employed drug in the treatment of OLP and their efficacy and safety are demonstrated. Also calcineurin inhibitors and photo-dynamic therapy are used in different studies for OLP management, with positive results. Conclusion:Topical steroids remain the first-line treatment for symptomatic OLP, however, many different pharmacological and non-pharmacological therapies would represent a valid alternative for its management, but, nowadays they require further investigations. atrophic-erosive type, but are rarely present in reticular forms [3].It is important to distinguish OLP from oral lichenoid lesions, which can be similar in appearance, but the latter represent a reaction to specific causal factors (e.g. dental materials, traumas, drugs) [5].Managing OLP is aimed at reducing symptoms and the manifestation of lesions, characterized by periods of exacerbation and quiescence. The first-line treatment is represented by the use of topical corticosteroids, although other effective therapies, like photodynamic therapy and the use of calcineurin inhibitors have recently been made available. MATERIALS AND METHODSWe examined the main publications related to OLP management, identified by searching the PubMed electronic database. We used the following search items: oral lichen planus, oral lichen planus management, oral lichen planus treatment, oral lichen planus therapy, randomized trial oral lichen planus, oral lichen planus placebo, oral lichen planus

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Efficacy of topical tacrolimus for oral lichen planus: real‐life experience in a retrospective cohort of patients with a review of the literature

Cited by 19 publications

References 35 publications

Topical tacrolimus, triamcinolone acetonide, and placebo in oral lichen planus: a pilot randomized controlled trial

Topical tacrolimus, triamcinolone acetonide, and placebo in oral lichen planus: a pilot randomized controlled trial

Comparison of topical clobetasol propionate 0.05% and topical tacrolimus 0.1% in the treatment of cutaneous lichen planus

Clinical Management of Oral Lichen Planus: A Systematic Review

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