Efficacy of two-month treatment with Xiloial® eyedrops for discomfort from disposable soft contact lenses

Abstract

Purpose:To evaluate the efficacy and tolerability of Xiloial® monodose eyedrops in the treatment of patients suffering from subjective symptoms of discomfort related to disposable soft contact lens (dSCL) wear.Methods:Fifteen (12 female, three male, medium age 39 ± 9 years) dSCL wearers were enrolled. Inclusion criteria were Ocular Surface Disease Index (ODSI) symptom questionnaire score >12, tear film break-up time (TFBUT) <10 sec, Schirmer test I >10 mm over five minutes, mild punctuate keratopathy, and conjunctival staining (Oxford grading ≤4). Monodose Xiloial eyedrops were administered three times daily for a two-month period. Patients were evaluated at enrollment, after three days of washout (baseline), and after one and two months of treatment, by OSDI score, Schirmer test I, TFBUT, ferning test, ocular surface damage (Oxford grade), and serum albumin in tears (index of passive exudation related to serum leakage).Results:At endpoint versus baseline, respectively, the mean ± standard deviation of all variables improved as follows: OSDI (8.5 ± 3 versus 20.2 ± 1.6); TFBUT (9.6 ± 1.1 versus 7.1 ± 1.0); Oxford grading (0.5 ± 0.1 versus 3.6 ± 0.8); ferning test (2 ± 1 versus 2.4 ± 0.5); and Schirmer test I (14.6 ± 1.1 versus 12 ± 2.1), with P < 0.05 for all variables (Friedman and Wilcoxon tests). Tolerability was high, with no adverse events noted.Conclusions:A two-month treatment with Xiloial showed good tolerance and appeared to reduce ocular surface damage and symptoms of discomfort.

The Effect of an Artificial Tear Combining Hyaluronic Acid and Tamarind Seeds Polysaccharide in Patients with Moderate Dry Eye Syndrome: A New Treatment for Dry Eye

“…This fact produces effect on the ability of the admixture to retain water that, for some concentration ratios, turns out to be remarkably higher and in a most stable matter than shown by the 2 polymers in nonmixed form (13). This finding and a preliminary open-label clinical trial (14) suggest that the mixture of TS-polysaccharide and HA might have a role in the treatment of DED.…”

Report of the Inaugural Meeting of the TFOS i2 = initiating innovation Series: Targeting the Unmet Need for Dry Eye Treatment

“…Scleral lens device to maintain a reservoir of tears to wet and lubricate the ocular surface 267,268 Acupuncture Possible effects on dry eye signs and symptoms, as compared to sham-treated controls or artificial tears [269][270][271] ShengJinRun ZaoYangXue granules Improve tear flow and reduce dry eye symptoms 272 Korean red ginseng Improve tear film stability and reduce dry eye symptoms 273 Suppressing transient receptor potential vanilloid 1 (TRPV1) receptor Trefoil factor family peptide 3 (TFF3) Stabilize mucous layer 279,280 Nerve growth factor & mimetics Increase goblet cell number and MUC5AC production; increase corneal sensitivity; promote corneal epithelial wound healing 281,282 Tamarind seed polysaccharide Mimic the mucoadhesive mucin properties [283][284][285][286] Nanoparticles Deliver plasmids coding for MUC5AC protein to the ocular surface 287,288 M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 294,295 Salivary gland transplantation Replace dysfunctional lacrimal gland [296][297][298] Generation of two-and threedimensional lacrimal gland constructs for lacrimal gland regeneration Serve as bioengineered lacrimal gland replacement 299 Oculeve electrode device Stimulate the lacrimal nerve to induce aqueous tear production [300][301][302] Oral anethole triothine Increase Schirmer wetting score 303 Oral uridine Stimulate tear and mucin secretion after metabolism into P2Y2 agonist 304 Oral hydroxychloroquine Increase Schirmer wetting score in in Sjögren's syndrome patients with anti-fodrin antibodies 305 Oral pilocarpine and cevimeline Reduce subjective eye symptoms in Sjögren's syndrome patients, with no effect on tear volume [306][307][308] Lacritin...…”

Dual-Polymer Drops, Contact Lens Comfort, and Lid Wiper Epitheliopathy

“…Rewetting drops are typically used to hydrate and lubricate contact lenses and the ocular surface before and during contact lens wear, as well as preventing drying by stabilizing the tear film and reducing surface tension. 23 Over the past 5 years, a number of topical lubricating formulations containing a variety of ingredients, including polyethylene glycol 400 0.4% and propylene glycol 0.3%, 24 , 25 biopolymer tamarind seed polysaccharide–hyaluronic acid, 26 and azithromycin ophthalmic solution 1.0%, 27 have been studied for alleviating dryness and discomfort associated with contact lens wear. Development of new lubricating drop formulations has evolved with better understanding of the roles of tears and tear film osmolarity, and the involvement of ocular surface inflammation.…”