Efficacy of tyndalizedLactobacillus acidophilus in acute diarrhea

Khanna, Vivek; Alam, Seema; Malik, Ajamaluddin; Malik, Abida

doi:10.1007/bf02731667

Cited by 42 publications

(33 citation statements)

References 12 publications

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“…However, lactobacilli also failed to shorten the duration of diarrhoea. At least three randomized controlled trials (RCTs) in developing countries negated the beneficial effect of Lactobacillus GG and L .acidophilus in acute diarrhoea, likely related to the distinct aetiological profile [16,33,50]. In children with more severe diarrhoea, there was no demonstrable benefit of L. casei GG [16,50].…”

Section: Treatment Of Infectious Gastroenteritismentioning

confidence: 96%

Probiotics in infectious diarrhoea in children: are they indicated?

et al. 2007

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Infectious gastroenteritis continues to be a leading cause of mortality and morbidity worldwide. The cornerstone of treatment remains replacement of water and electrolyte losses with oral rehydration solution. Until a few years ago, probiotics were discussed primarily in the context of alternative medicine, but they are now entering mainstream medical practice since a decrease of the severity and duration of infectious gastroenteritis in approximately 24 hours has been shown for some strains. Therefore, probiotics are a potential add-on therapy in acute gastro-enteritis. The shortening of the duration of diarrhoea and the reduction in hospital stay result in a social and economic benefit. Evidence found in viral gastroenteritis is more convincing than in bacterial or parasitic infection. Mechanisms of action are strain specific and only those commercial products for which there is evidence of clinical efficacy should be recommended. Timing of administration is also of importance. In acute gastroenteritis, there is evidence for efficacy of some strains of lactobacilli (e.g. Lactobacillus caseii GG and Lactobacillus reuteri) and for Saccharomyces boulardii. Probiotics are "generally regarded as safe", but side effects such as septicaemia and fungaemia have very rarely been reported in high-risk situations. Although most studies conclude in a statistically significant shortening of the duration of diarrhea, the clinical relevance of this finding is limited. In conclusion, selected strains of probiotics result in a statistically significant but clinically moderate benefit in shortening the duration of diarrhoea caused by acute infectious gastroenteritis.

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Section: Treatment Of Infectious Gastroenteritismentioning

confidence: 96%

Probiotics in infectious diarrhoea in children: are they indicated?

et al. 2007

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“…Isolaruri et al 1994 (26) observed that the mean duration of diarrheoa was significantly lower in probiotics treated group (1.4 day) compared to yoghurt treated group (2.4 days). While with use of probiotics Billoo et al 2000 (27) , Jobst Henker et al (21) , Enduardo et al (22) Roberto Berni Canani et al (28) and Khanna et al 2000 (23) observed that the mean duration of diarrhoea was 3.6 days, 2.5 days, 58.5 hours, 78.5 hours and 58.78 hours respectively. Similarly Szajewska H. et al 2006; (29) observed that probiotics use were significantly reduced the duration of diarrhoea.…”

Section: Discussionmentioning

confidence: 99%

A Study of Probiotics Use in the Acute Diarrhoea in the Infants & Children

Beniwal¹

2017

jmscr

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“…The summary effect size of duration of diarrhea for all included data for probiotics in comparison to placebo in 19 trials [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] was -0.67 with 95% CI= -0.95 to -0.38 (P< 0.0001, Fig. 2a).…”

Section: Duration Of Diarrhea (Day)mentioning

confidence: 99%