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AbstractObjective: The purpose of this study was to investigate the removal efficiency of calcium hydroxide (CH) by CanalBrush, Vibringe, laser-activated irrigation (LAI), conventional syringe irrigation (CSI), XP-endo Finisher, and passive ultrasonic irrigation (PUI) in the root canal walls. Materials and Methods: Ninety-eight human mandibular premolar teeth were prepared. Root canals were filled with CH. The roots were divided into six experimental groups (n=15/group) according to the irrigation protocol used: group 1 (CSI), group 2 (Vibringe), group 3 (CanalBrush), group 4 (XP-endo Finisher), group 5 (PUI), and group 6 (LAI). The amount of residual CH in the canal walls for each canal third was scored. Data were analysed by using Kruskal-Wallis and Bonferroni-correction Mann-Whitney U tests. Results: None of the investigated protocols renders the root canal walls free of CH remnants. Significant differences were found between tooth regions in terms of CH removal (p<0.05), and all groups except group 6 (LAI) showed more residual CH in the apical region. PUI and LAI eliminated significantly more CH than CSI from the middle and apical thirds of the root canal, respectively. Conclusion: The activation of sodium hypochlorite with various devices increased CH removal at the apical and middle part of the canal. LAI and PUI produce better results in the apical and middle thirds, respectively. Amaç: Bu çalışmanın amacı, XP-endo Finisher, Vibringe, lazerle aktive edilmiş irrigasyon (LAİ), geleneksel iğne irrigasyonu (Gİİ) ve pasif ultrasonik irrigasyonun (PUİ) kök kanal duvarlarından kalsiyum hidroksit (KH) uzaklaştırma etkinliğini araştırmaktır. Gereç ve Yöntemler: Doksan sekiz adet alt çene küçük azı dişinin kök kanalları prepare edildi ve KH ile dolduruldu. Kökler, irrigasyon protokolüne göre rastgele altı deney grubuna ayrıldı (n=15/grup): grup 1 (Gİİ), grup 2 (Vibringe), grup 3 (CanalBrush), grup 4 (XP-endo Finisher), grup 5 (PUİ) ve grup 6 (LAİ). Her bir kanal üçlüsü için kanal duvarlarında kalan KH miktarı skorlandı. Veriler, Kruskal-Wallis ve Bonferronidüzeltmeli Mann-Whitney U testleri kullanılarak analiz edildi.