Efficacy of Using Platelet Concentrates in the Management of Horizontal Ridge Defects (Experimental Study)

Anwar, Souzy; Lotfy, Mona; Kotry, Gehan S.; Karam, Sahar S.

doi:10.21608/adjalexu.2018.57605

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…This study showed the platelet concentrates have no effect on bone dimension (height and width) which is agreed with Anwar et al (16) , which concluded in a histological split mouth design in an experimental study the MPM and PRF showed a good quality of bone but better in MPM.…”

Section: Discussionsupporting

confidence: 91%

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Effect of mineralized plasmatic matrix(MPM) platelet concentrate versus platelet-rich fibrin for socket preservation: Comparative study

Maraqa

Elmohandes

Hosni

2023

Al-Azhar Journal of Dental Science

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Objective: Adequate alveolar ridge is needed for a successful implant placement to attain predictable long-term functioning and an esthetic treatment outcome. Various bone graft materials such as platelet-rich fibrin (PRF) and mineralized plasmatic matrix (MPM) are widely used in oral and maxillofacial surgery to stimulate a new bone tissue formation and accelerate healing. This study was aimed to evaluate and compare the effect of (PRF) and (MPM) grafting materials in alveolar socket after extraction using cone beam computed tomography (CBCT) imaging to evaluated bone density, bone height and bone width. Subjects and methods: Twenty patients with permanent tooth indicated for extraction were collected from outpatient clinic in the Faculty of Dentistry, Al-Azhar University (boys-Cairo). The patients were divided randomly into two groups: study group, where ten patients' sockets were filled with mineralized plasmatic matrix (MPM) and control group where ten patients socket filled with platelet-rich fiber (PRF). Results: The results showed an increase in bone density in the study group, in comparison according to height and width, both groups showed statistically significant decrease in bone height and width, but the study group show lower decrease in bone height and width than the control group. Conclusion: The bone graft mixed with platelet has a superior biological effect on bone regeneration. Using MPM in socket preservation has a better radiological evidence to bone formation than PRF alone.

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Section: Discussionsupporting

confidence: 91%

“…In comparison between the two groups according to density, the both groups show a statistically significant difference in mean density, but MPM group showing a higher bone density than PRF group. Which is agreed with Jean Périssé (9) in his histological study and Anwar et al (16) .…”

Section: Discussionsupporting

confidence: 89%

Effect of mineralized plasmatic matrix(MPM) platelet concentrate versus platelet-rich fibrin for socket preservation: Comparative study

Maraqa

Elmohandes

Hosni

2023

Al-Azhar Journal of Dental Science

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“…In each dog, four critical-sized horizontal alveolar ridge defects were created preserving the lingual walls. The dimensions of all defects were standardized to be about 7 mm mesio-distally, 8 mm apicocoronally and 5 mm bucco-lingually (21,22). With the aid of rotary burs, bone was removed with thourough irrigation using sterile saline to avoid overheating.…”

Section: Study Design and Groupingmentioning

confidence: 99%

Histomorphometric Assessment of Autogenous Stem Cell Therapy in Horizontal Alveolar Ridge Augmentation (Experimental Study)

El-Kimary

Hommos

Sayed

et al. 2021

Alexandria Dental Journal

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INTRODUCTION:Augmentation of deficient alveolar ridge is a challenging task in periodontal regenerative therapy. The gold standard therapeutic modality for managing these defects is autogenous bone grafting. But, this approach was hampered by increased patient morbidity. Thus, recent advances in molecular and cellular biology have shed light on the ''bioengineering'' technology which seeks to introduce the incorporation of stem cells in periodontal regeneration. OBJECTIVE:The aim of this experimental study was to evaluate, histomorphometrically, the efficacy of guided bone regeneration (GBR) technique using autogenous bone marrow-derived mesenchymal stem cells (BMSCs) loaded on β-tricalcium phosphate (β-TCP) alloplast as a scaffold, in managing horizontal alveolar ridge defects. MATERIALS AND METHODS: Sixteen critical-sized horizontal ridge defects were created in four healthy mongrel dogs after bilateral extraction of the mandibular third and fourth premolars. In a split mouth design; the experimental group (right side): comprised eight ridge defects managed using GBR approach (autogenous BMSCs + β-TCP + collagen membrane). The control group (left side): comprised eight ridge defects were left empty to heal spontaneously. Dogs were sacrificed at 1 and 2 months intervals for histomorphometric assessment using Image J software to measure osteoblastic count (OC) from the obtained histological sections. RESULTS:The experimental group showed a statistically significant increase in OC at both follow up intervals of the study. CONCLUSIONS: GBR technique using autogenous BMSCs/ β-TCP composites was effective in managing horizontal ridge defects. Osteogenic properties and bone regenerative capacity of alloplasts can be greatly enhanced using this technique in periodontal regenerative surgeries.

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Immuno-histopathologic evaluation of mineralized plasmatic matrix in the management of horizontal ridge defects in a canine model (a split-mouth comparative study)

Anwar

Hamid

2022

Odontology

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Our research aimed to investigate the effect of combining biphasic calcium phosphate (BCP) alloplast with mineralized plasmatic matrix (MPM) as compared with platelet-rich fibrin (PRF) on the quality and quantity of bone formation and maturation at surgically created horizontal critical-sized ridge defects (HRDs) in a canine model. We used a split-mouth design using the third and fourth mandibular premolars of the mongrel dogs. Twelve defects on the left side (experimental group, I) were managed with MPM composite mixed with BCP alloplast, MPM compact layer. On the right side (control group, II), another 12 defects were managed with PRF mixed with BCP alloplast, followed by the application of PRF compact strips. Finally, both were covered by a collagen membrane. Dogs were euthanized at 4, 8, and 12 weeks, and the studied defects were processed to evaluate treatment outcome, including mean percentage of bone surface area, collagen percentage, and osteopontin (OPN) immunoreaction. Our results revealed that the mean percentage of bone surface area was significantly increased in the experimental group treated with MPM at all time intervals as compared with the PRF group. Decreased collagen percentage and increased OPN immunoreactivity showed significant results in the MPM group as compared with PRF at 4 and 8 weeks postoperatively, respectively. In conclusion, MPM accelerates the formation of superior new bone quality when used in the treatment of HRDs.

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Efficacy of Using Platelet Concentrates in the Management of Horizontal Ridge Defects (Experimental Study)

Cited by 3 publications

References 16 publications

Effect of mineralized plasmatic matrix(MPM) platelet concentrate versus platelet-rich fibrin for socket preservation: Comparative study

Effect of mineralized plasmatic matrix(MPM) platelet concentrate versus platelet-rich fibrin for socket preservation: Comparative study

Histomorphometric Assessment of Autogenous Stem Cell Therapy in Horizontal Alveolar Ridge Augmentation (Experimental Study)

Immuno-histopathologic evaluation of mineralized plasmatic matrix in the management of horizontal ridge defects in a canine model (a split-mouth comparative study)

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