Efficacy of various pyrethroid structures against a highly metabolically resistant isogenic strain of <i>Helicoverpa armigera</i> (Lepidoptera: Noctuidae) from China

Tan, Jian; McCaffery, Alan R.

doi:10.1002/ps.1419

Cited by 23 publications

(14 citation statements)

References 38 publications

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“…Results of toxicity studies with the insecticides examined in the present study have also been reported for several pest moth species. Third‐instar larvae of cotton bollworm ( Helicoverpa armigera ) topically treated with beta‐cyfluthrin produced 72‐h LD50s of approximately 4.7 × 10 –2 and 9.9 × 10 –2 µg/g larva (Martin et al 2003; Tan and McCaffery 2007). The 96‐h LD50 value of third‐instar monarchs treated with beta‐cyfluthrin is 1.8 × 10 –2 µg/g.…”

Section: Discussionmentioning

confidence: 99%

Assessing Field-Scale Risks of Foliar Insecticide Applications to Monarch Butterfly (Danaus plexippus) Larvae

Krishnan

Zhang

Bidne³

et al. 2020

Environmental Toxicology and Chemistry

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Establishment and maintenance of milkweed plants (Asclepias spp.) in agricultural landscapes of the north central United States are needed to reverse the decline of North America's eastern monarch butterfly (Danaus plexippus) population. Because of a lack of toxicity data, it is unclear how insecticide use may reduce monarch productivity when milkweed habitat is placed near maize and soybean fields. To assess the potential effects of foliar insecticides, acute cuticular and dietary toxicity of 5 representative active ingredients were determined: beta‐cyfluthrin (pyrethroid), chlorantraniliprole (anthranilic diamide), chlorpyrifos (organophosphate), and imidacloprid and thiamethoxam (neonicotinoids). Cuticular median lethal dose values for first instars ranged from 9.2 × 10–3 to 79 μg/g larvae for beta‐cyfluthrin and chlorpyrifos, respectively. Dietary median lethal concentration values for second instars ranged from 8.3 × 10–3 to 8.4 μg/g milkweed leaf for chlorantraniliprole and chlorpyrifos, respectively. To estimate larval mortality rates downwind from treated fields, modeled insecticide exposures to larvae and milkweed leaves were compared to dose–response curves obtained from bioassays with first‐, second‐, third‐, and fifth‐instar larvae. For aerial applications to manage soybean aphids, mortality rates at 60 m downwind were highest for beta‐cyfluthrin and chlorantraniliprole following cuticular and dietary exposure, respectively, and lowest for thiamethoxam. To estimate landscape‐scale risks, field‐scale mortality rates must be considered in the context of spatial and temporal patterns of insecticide use. Environ Toxicol Chem 2020;39:923–941. © 2020 SETAC

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Section: Discussionmentioning

confidence: 99%

Assessing Field-Scale Risks of Foliar Insecticide Applications to Monarch Butterfly (Danaus plexippus) Larvae

Krishnan

Zhang

Bidne³

et al. 2020

Environmental Toxicology and Chemistry

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“…The degree of P450-mediated resistance to pyrethroids in the YS-FP strain from China was found to depend on the nature of the alcohol moiety in the pyrethroid structure (Yang et al, 2005). Resistance to pyrethroids in the CMR strain from China was also mainly due to enhanced oxidative metabolism, and substitution of the phenoxybenzyl group found in the alcohol moiety of most commercial pyrethroids with a polyfluorobenzyl group (eg in tefluthrin, benfluthrin and transfluthrin) overcame most of the resistance (Tan and McCaffery, 2007). However, esterase-based pyrethroid resistance in an Australian strain of H. armigera was related to the nature of the acid moiety of the pyrethroid structure, being higher for pyrethroids with aromatic acyl groups such as fenvalerate and esfenvalerate (Gunning et al, 2007).…”

Section: Introductionmentioning

confidence: 95%

Overexpressed esterases in a fenvalerate resistant strain of the cotton bollworm, Helicoverpa armigera

Yang

Yuan

et al. 2011

Insect Biochemistry and Molecular Biology

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“…4-hydroxydeltamethrin was also detected as first degradation product in Tribolium castaneum [ 16 ]. For a strain of a cotton bollworm Helicoverpa armigera with upregulated P450 monooxygenases, Tan and McCaffery showed that structures with polyfluorobenzyl alcohols, lowered the resistance level [ 17 ]. The involved enzymes degrade the infiltrated insecticide and reduce or avoid its effect because only small amounts of the enzyme, if any at all, reach the target receptor.…”

Section: Introductionmentioning

confidence: 99%

Contact Bioassays with Phenoxybenzyl and Tetrafluorobenzyl Pyrethroids against Target-Site and Metabolic Resistant Mosquitoes

Horstmann

Sonneck

2016

PLoS ONE

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BackgroundMosquito strains that exhibit increased tolerance to the chemical class of compounds with a sodium channel modulator mode of action (pyrethroids and pyrethrins) are typically described as “pyrethroid resistant”. Resistance to pyrethroids is an increasingly important challenge in the control of mosquito-borne diseases, such as malaria or dengue, because one of the main interventions (the distribution of large numbers of long-lasting insecticide-treated bed nets) currently relies entirely on long-lasting pyrethroids. Increasing tolerance of target insects against this class of insecticides lowers their impact in vector control. The current study suggests that the level of metabolic resistance depends on the structure of the molecule and that structurally different compounds may still be effective because detoxifying enzymes are unable to bind to these uncommon structures.MethodsTreated surface contact bioassays were performed on susceptible Aedes aegypti, East African knockdown resistance (kdr) Anopheles gambiae (strain RSP-H) and metabolically resistant Anopheles funestus (strain FUMOZ-R) with different pyrethroids, such as cypermethrin, ß-cyfluthrin, deltamethrin, permethrin and transfluthrin (alone and in combination with the synergist piperonyl butoxide). The nonfluorinated form of transfluthrin was also assessed as a single agent and in combination with piperonyl butoxide.ResultsAlthough the dosages for pyrethroids containing a phenoxybenzyl moiety have exhibited differences in terms of effectiveness among the three tested mosquito species, the structurally different transfluthrin with a polyfluorobenzyl moiety remained active in mosquitoes with upregulated P450 levels. In trials with transfluthrin mixed with piperonyl butoxide, the added synergist exhibited no efficacy-enhancing effect.ConclusionThe results of this study suggest that transfluthrin has the potential to control P450-mediated metabolically resistant mosquitoes because the structural formula of transfluthrin differs from that of the tested pyrethroids, which are used in vector control. The P450-detoxifying enzymes of the Anopheles funestus FUMOZ-R mosquitoes seem to bind preferably at the phenoxybenzyl moiety and appear to be unable to degrade transfluthrin with its tetrafluorobenzyl moiety. Inhibition of the class of monooxygenases by piperonyl butoxide revealed no increase of efficacy of the pure transfluthrin compound, which also indicates that the P450 enzymes potentially do not impact the efficacy of transfluthrin.

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Efficacy of various pyrethroid structures against a highly metabolically resistant isogenic strain of Helicoverpa armigera (Lepidoptera: Noctuidae) from China

Cited by 23 publications

References 38 publications

Assessing Field-Scale Risks of Foliar Insecticide Applications to Monarch Butterfly (Danaus plexippus) Larvae

Assessing Field-Scale Risks of Foliar Insecticide Applications to Monarch Butterfly (Danaus plexippus) Larvae

Overexpressed esterases in a fenvalerate resistant strain of the cotton bollworm, Helicoverpa armigera

Contact Bioassays with Phenoxybenzyl and Tetrafluorobenzyl Pyrethroids against Target-Site and Metabolic Resistant Mosquitoes

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