Efficacy of vibegron for refractory enuresis after combination therapy with desmopressin, solifenacin, and wireless alarm

Fujinaga, Shuichiro; Onuki, Yuta

doi:10.1111/ped.15248

Cited by 3 publications

(4 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The success rate of solifenacin for the treatment of NE varies from 10 % to 65 %. The CR rate of solifenacin in this study (30.0 %) was consistent with that of Ghanavati et al [4] , but lower than that of Fujinaga et al [9] . This difference may be related to short-term medication, efficacy standards and ethnic or sociocultural differences.…”

Section: Resultssupporting

confidence: 91%

See 1 more Smart Citation

Clinical Study on the Treatment of Pediatric Primary Nocturnal Enuresis by Integrated Traditional Chinese and Western Medicine

Hu¹,

Wan²

2022

IJPS

View full text Add to dashboard Cite

To investigate the curative effect of integrated traditional Chinese and Western medicine in the treatment of children with primary nocturnal enuresis is the objective of the study. 160 children with primary nocturnal enuresis were randomly divided into four groups and received suoquan capsules, solifenacin combined with suoquan capsules, solifenacin or behavioral intervention for 2 mo. The response rates of each group were evaluated and logistic regression analysis was used to analyze the influencing factors of curative effect. In addition, the patients were followed up after 3 mo to investigate the recurrence rate. The complete remission (complete response) rate in solifenacin combined with suoquan capsules group was higher than that in behavioral intervention group (37.5 % vs. 7.5 %, p=0.007). The complete response rate and non-response rate in the solifenacin group were lower than those in the solifenacin combined with suoquan capsules group (all p<0.05). The recurrence rate in the solifenacin group was significantly higher than that in the solifenacin combined with suoquan capsules group (72.5 % vs. 30.0 %, p=0.027). Multivariate analysis showed that treatment group, enuresis frequency and age were independent predictors of complete response at 2 mo. Integrative traditional Chinese and Western medicine has good effect in the treatment of children with primary nocturnal enuresis and the recurrence rate is low. Enuresis frequency, treatment method and age were important predictors of complete remission after treatment.

show abstract

Section: Resultssupporting

confidence: 91%

“…Fujinaga et al showed that solifenacin produced a statistically significant reduction in the number of wet nights (62.9 %) compared to placebo (2.4 %) [9] . The success rate of solifenacin for the treatment of NE varies from 10 % to 65 %.…”

Section: Resultsmentioning

confidence: 99%

Clinical Study on the Treatment of Pediatric Primary Nocturnal Enuresis by Integrated Traditional Chinese and Western Medicine

Hu¹,

Wan²

2022

IJPS

View full text Add to dashboard Cite

show abstract

“…Recently, the therapeutic efficacy of vibegron, a novel β3-adrenergic receptor stimulator for overactive bladder, has been reported for the treatment of nocturnal enuresis. 51 According to this report, unlike anticholinergic agents, vibegron caused fewer symptoms of constipation and xerostomia. The authors evaluated the effect of shortening the duration of treatment with vibegron for drug-resistant nocturnal enuresis.…”

Section: How To M a Nage Pat I E N T S R E F R Ac Tory To De Smopr E ...mentioning

confidence: 82%

“…However, it should be noted that anticholinergics in Japan are not approved for the treatment of nocturnal enuresis, and pediatric doses have not been established for the treatment of overactive bladder. Recently, the therapeutic efficacy of vibegron, a novel β3‐adrenergic receptor stimulator for overactive bladder, has been reported for the treatment of nocturnal enuresis 51 . According to this report, unlike anticholinergic agents, vibegron caused fewer symptoms of constipation and xerostomia.…”

Section: How To Manage Patients Refractory To Desmopressin and Alarm ...mentioning

confidence: 99%

Management of treatment‐resistant nocturnal enuresis

Tsuji

Kaneko

2023

Pediatrics International

View full text Add to dashboard Cite

Nocturnal enuresis is defined as intermittent urinary incontinence during sleep in children 5 years of age and older, occurring at least once a month for at least 3 months. In Japan, pediatricians who do not specialize in nocturnal enuresis have become more proactive in treating the condition since 2016, when the guidelines for treating it were revised for the first time in 12 years. For monosymptomatic nocturnal enuresis, the first step is lifestyle guidance, with a focus on the restriction of fluid intake at night; however, if lifestyle guidance does not decrease the frequency of nocturnal enuresis, aggressive treatment should be added. The first choice of aggressive treatment is oral desmopressin, an antidiuretic hormone preparation, or alarm therapy. However, there remain patients whose wet nights do not decrease with oral desmopressin or alarm therapy. In such cases, it is necessary to reconfirm the method of desmopressin administration and check for factors that may decrease the efficacy of desmopressin. If alarm therapy does not increase the number of dry nights, it is possible that the patient is fundamentally unsuitable for alarm therapy. If dry nights do not increase with oral desmopressin or alarm therapy, the next treatment strategy should be considered immediately to keep the patient motivated for treatment.

show abstract

Combination treatment with vibegron and solifenacin for refractory non‐monosymptomatic enuresis

Gonda,

Fujinaga,

Miyano

2023

Pediatrics International

Self Cite

View full text Add to dashboard Cite

We read with great interest the article by Uchihara et al. 1 The authors, in their retrospective study of 29 children with refractory enuresis that was unresponsive to conventional treatments, demonstrated that vibegron, a novel selected β3-adrenoreceptor agonist, may provide a promising treatment by increasing bladder capacity. In 2020, we first reported vibegron as a useful treatment option for refractory monosymptomatic nocturnal enuresis (MNE), particularly in those with constipation. 2 We revealed a significantly higher proportion of patients with refractory MNE who received combination treatment with vibegron and solifenacin in the response group than in the no-response group. 3 However, the efficacy of the combination treatment for refractory non-monosymptomatic nocturnal enuresis (NMNE) remains unknown.Here, we report on the effects of vibegron treatment for 3 months as an add-on therapy in children with NMNE that is refractory to solifenacin-i.e., with persistent daytime urinary incontinence (DUI) after 3 months of solifenacin. This retrospective study enrolled 21 children with refractory NMNE (median age 7.4 years) at Saitama Children's Medical Center from January 2019 to September 2022. For children with NMNE, the first step was lifestyle guidance such as regular voiding habits and a good voiding posture, and solifenacin (2.5 mg for patients weighing <25 kg, or 5 mg for patients weighing ≥25 kg; Vesicare, tablet, Astellas Pharma Inc., Tokyo, Japan) was initiated after constipation was excluded or successfully treated. However, all patients had persistent DUI and wetting nights (WN) after monotherapy with solifenacin for a median duration of 4.2 months, and subsequently received the combination treatment with vibegron (15 mg for patients weighing <25 kg, or 25 mg for patients weighing ≥25 kg; Beova, trituration tablet, Kissei Pharma Co.

show abstract

Efficacy of vibegron for refractory enuresis after combination therapy with desmopressin, solifenacin, and wireless alarm

Cited by 3 publications

References 4 publications

Clinical Study on the Treatment of Pediatric Primary Nocturnal Enuresis by Integrated Traditional Chinese and Western Medicine

Clinical Study on the Treatment of Pediatric Primary Nocturnal Enuresis by Integrated Traditional Chinese and Western Medicine

Management of treatment‐resistant nocturnal enuresis

Combination treatment with vibegron and solifenacin for refractory non‐monosymptomatic enuresis

Contact Info

Product

Resources

About