Efficacy of vitamin A in experimentally induced acute otitis media

Aladağ, İbrahim; Güven, Mehmet; Eyibilen, Ahmet; Sahin, Şevki; Köseoğlu, Doğan

doi:10.1016/j.ijporl.2006.12.019

Cited by 16 publications

(9 citation statements)

References 20 publications

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“…We found that pretreatment with CAPE reduced the expression of SOD in H 2 O 2 stimulated HMEECs. There are the reports about the increased levels of antioxidants after surgery or vitamin A treatment [7,24]. However, our result might be explained by adjustment of oxidant and antioxidant balance in the cell line and suggested that nonenzymatic antioxidants like CAPE react with oxygen free radicals and decrease the demand for endogenous O 2 -scavenging antioxidants such as SOD.…”

Section: Discussionmentioning

confidence: 58%

Effect of caffeic acid phenethyl ester (CAPE) on H2O2 induced oxidative and inflammatory responses in human middle ear epithelial cells

Song¹,

Lim²,

Kim³

et al. 2012

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 58%

Effect of caffeic acid phenethyl ester (CAPE) on H2O2 induced oxidative and inflammatory responses in human middle ear epithelial cells

Song¹,

Lim²,

Kim³

et al. 2012

International Journal of Pediatric Otorhinolaryngology

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“…Acute otitis media (AOM) is one of the commonest pediatric diseases [2–4]. Streptococcus pneumonia and Haemophilus influenzae are the most common causative microorganisms for AOM [5–7].…”

Section: Introductionmentioning

confidence: 99%

Montelukast is as effective as penicillin in treatment of acute otitis media: An experimental rat study

Uçar

Huseynov

Çoban

et al. 2013

Med Sci Monit Basic Res

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BackgroundLeukotrienes are the major factors in the formation of edema and mucus, as well as development of tuba Eustachii dysfunction in acute otitis media. We developed an experimental acute suppurative otitis media model and compared the responses of rats to penicillin and combinations of leukotriene antagonist with respect to histopathological observations conducted in early and late phases.Material/MethodsA total of 83 ears from 56 Wistar rats were used in this study. Pneumococcus suspension was injected trans-tympanically into all rats. Subjects were classified into 4 different groups with 14 rats in each. In Group A, intramuscular penicillin G was injected for a period of 5 days. In Group B, intraperitoneal montelukast was injected for 21 days in addition to penicillin. In Group C, intraperitoneal montelukast isotonic NaCl in Group D was injected into rats for 21 days.ResultsNo significant difference was found between the groups, except for mucosal vascularization with respect to mucosal and TM parameters in early phases. Furthermore, considerable deviations were observed for the recuperation of TM and mucosal inflammation for groups in which subjects were injected with montelukast as compared to other groups of the study in the late phases.ConclusionsWhen the parameters of inflammation in the rat middle ear were compared with each other, most of these parameters did not show any statistically significant beneficial effects in montelukast and penicillin groups.

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“…Superoxide dismutase, one of the most important enzymatic antioxidants, also contains Zn and Cu [19] . Serum Cu levels are increased in some infections and inflammatory processes, as previously noted [7,20] .…”

mentioning

confidence: 99%

Serum Trace Elements and Heavy Metal Levels in Patients Diagnosed with Chronic Otitis Media and Their Association with Surgical Treatment Outcomes

Bozan¹,

Dinç²,

Demır³

et al. 2017

Int Adv Otol

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OBJECTIVE:To determine the serum iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), magnesium (Mg), cobalt (Co), and lead (Pb) levels in patients with chronic otitis media (COM) and to evaluate the association of the serum levels of these elements with treatment outcomes. MATERIALS and METHODS:Thirty-one healthy volunteers and 31 patients with COM were prospectively included in this study. Serum levels of Fe, Zn, Mn, Mg, Cu, Co, and Pb were determined by an atomic absorption UNICAM-929 spectrophotometer.RESULTS: Serum Co, Pb, and Fe levels were significantly increased (p<0.001) and serum Cu, Zn, Mg, and Mn levels were significantly reduced in patients with COM compared with controls (p<0.001). Serum Co and Mn levels were significantly decreased (p<0.001 and p<0.005, respectively) and serum Cu levels were significantly increased after surgery (p<0.005). The other evaluated blood chemicals and heavy metals did not exhibit significant differences (p>0.05). CONCLUSION:Significant alterations in the serum chemical composition of patients with COM were observed. Moreover, with surgical treatment, serum levels of some of these chemicals were significantly altered. Further prospective studies are warranted to elucidate the exact association of these alterations in the etiopathogenesis of COM.

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Efficacy of vitamin A in experimentally induced acute otitis media

Cited by 16 publications

References 20 publications

Effect of caffeic acid phenethyl ester (CAPE) on H2O2 induced oxidative and inflammatory responses in human middle ear epithelial cells

Effect of caffeic acid phenethyl ester (CAPE) on H2O2 induced oxidative and inflammatory responses in human middle ear epithelial cells

Montelukast is as effective as penicillin in treatment of acute otitis media: An experimental rat study

Serum Trace Elements and Heavy Metal Levels in Patients Diagnosed with Chronic Otitis Media and Their Association with Surgical Treatment Outcomes

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