Efficacy of Yangxin Recipe in Combination with Conventional Western Medicine in Treatment of Angina Pectoris of Coronary Heart Disease

Abstract

Objective To study the efficacy of Yangxin Recipe (YXR) in patients with stable angina pectoris of coronary heart disease and its impacts on coronary CT angiography. Methods A total of 78 patients with coronary heart disease and angina pectoris were randomly divided into a control group (n = 39) and a YXR group (n = 39). The control group adopted conventional Western medicine while the YXR group received conventional western medicine + oral administration of YXR. After six months of continuous treatment, the clinical efficacy, traditional Chinese medicine (TCM) syndrome scores, Pittsburgh Sleep Quality Index (PSQI), and the level of coronary CT vascular stenosis were observed. Results After treatment, the total effective rate of YXR was 92.31%, which was higher than ( P < 0.01) that of the western medicine control group. The total score of TCM syndromes in the YXR group was (14.44 ± 9.87), which was significantly lower than ( P < 0.001) that in the simple western medicine control group (22.44 ± 13.87). The degree of coronary stenosis in the YXR group decreased to (49.87 ± 7.82) %, which was significantly lower than ( P < 0.001) that in the western medicine control group (57.05 ± 9.92) %. Conclusion The efficacy of YXR + conventional western medicine in treating coronary heart disease and angina pectoris is significantly improved compared with the simple conventional western medicine.

Safflor yellow treating angina pectoris: A pharmacoeconomic evaluation and network meta-analysis

“…The studies were published between 2006 and 2019. Overall, 42 trials [12,20–60] with 4290 angina-pectoris patients were involved in the network meta-analysis, 2273 in the treatment group and 2017 in the control group. The sample sizes of the study participants ranged from 46 to 432.…”

“…As is shown in Figure 3, 2 closed loops were formed, focusing on the conventional treatment. 42 RCTs [12,20–60] for angina-pectoris treatment efficiency were estimated according to the efficacy evaluation criteria. ECG effects and hemorheological indicators were included in 40 RCTs [12,20–24,26–55,57–60] and 19 RCTs, [20,21,25–30,33–35,37,38,41,48,49,52,59,60] respectively.…”

Effects of Different Doses of Nitroglycerin Combined With Atenolol on Plasma Viscosity and Inflammatory Response in Patients With Angina Pectoris

“…LVEDD refers to the filling volume at the end of the left ventricular diastole, and its normal value is 75 ~ 160 mL. LVESV can reflect the systolic function of the left ventricle and its normal value is < 49 mL/m 2 [25,26]. It was found that LVEDD, LVESV and LVEF in the experimental group were significantly lower than those in the control group, which indicated that high-dose nitroglycerin combined with atenolol could more effectively improve the cardiac function of patients with angina pectoris compared with lowdose nitroglycerin.…”

Yangxin decoction for the treatment of angina pectoris of coronary heart disease: A systematic review of randomized controlled trial

“…[9–11] It consists of 2 types: stable and unstable angina. [12,13] According to theory of traditional Chinese medicine (TCM), AP belongs to the “ Xiong Bi ,” “chest arthralgia,” and “heartache.” Its major pathogenesis is explained by “heart pulse stasis” and “Qi statsis.” [14–20] Clinical practice has proven that Yangxin Decoction (YXD) has unique advantages for the management of patients with AP of CHD. [21–29]…”

“…[14][15][16][17][18][19][20] Clinical practice has proven that Yangxin Decoction (YXD) has unique advantages for the management of patients with AP of CHD. [21][22][23][24][25][26][27][28][29] Previous studies have reported that YXD can improve the AP of CHD by increasing the levels of serum 6-Keto-PGF 1α, high-density lipoprotein cholesterol, and apolipoprotein A. [30,31] It can also enhance myocardial function and aortic abnormalities.…”