Efficacy of Zhengtian Pill for migraine prophylaxis: A randomized, multicenter, double-blind, placebo-controlled, parallel-group study

Chuanxiong chadiao powder, a famous Chinese herbal prescription, for headache: A systematic review and meta-analysis

“…Adverse event monitoring was reported in 22 studies (59%) 22 (Table 4), while the other 15 studies (41%) did not mentioned. Serious adverse events, which were life-threatening, prolonged hospitalization, or caused death, were not found in all 37 included studies.…”

“…Only one study 22 published in English, while the rest of the studies in Chinese language. These studies covered a wide range of headaches, including primary headache such as migraine and tension-type headache and secondary headache.…”

“…22,[50][51][52]54 The data from four studies 22,50-52 showed significant effects of modified CXCP for reducing both headache frequency(n = 480, RR −0.64, 95% CI −0.67 to −0.61, P < 0.001, heterogeneity 2 = 0.17, P = 0.98, I 2 = 0%) and headache duration (n = 480, RR −1.32, 95% CI −2.33 to −0.30, P < 0.05, heterogeneity 2 = 28.67, P < 0.00001, I 2 = 90%) compared with control group after 4-week treatment. The heterogeneity was significant difference in our meta-analysis of headache duration.…”

“…None of the included studies reported concealment allocation. The blinding of participants and personnel which described as double-blind was mentioned in 2 studies 22,52 , whereas all included studies did not provide enough information to assess the blinding of outcome assessment (unclear). Three of 37 studies 28,31,40 were judged to meet the criterion of incomplete out-come data and selective reporting of all included studies was unclear.…”

“…Three studies, 23,49,52 which changed the overall results after sensitivity analyses, were considered to be the potential sources of the heterogeneity. After removing these three studies, 34 studies 22,50,51,[53][54][55][56][57][58] reported that the modified CXCP significantly increased the total clinical effective rate of headache compared with controls (n = 3076, RR 1.26, 95% CI 1.21 to 1.31, P < 0.00001, heterogeneity 2 = 42.42, P = 0.10, I 2 = 25%) (Fig. 4).…”