Efficacy, Safety and Acceptability of Orthokeratology on Slowing Axial Elongation in Myopic Children by Meta-Analysis

Li, Shiming; Kang, Meng-Tian; Wu, Shanshan; Liu, Luo-Ru; He, Lin; Chen, Zhuo; Wang, Ke

doi:10.3109/02713683.2015.1050743

Cited by 111 publications

(82 citation statements)

References 32 publications

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“…Orthokeratology and low‐dose (0.01%) atropine were considered to be more efficacious for slowing childhood myopia progression than single‐vision distance spectacles by most respondents. In a recent meta‐analysis, combining data from three randomised controlled trials and six cohort studies, orthokeratology was reported to significantly reduce axial elongation relative to a control (single‐vision distance) intervention . While this technique shows promise as an intervention for reducing childhood myopia progression, there are several important limitations to the existing research evidence.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent meta-analysis, combining data from three randomised controlled trials and six cohort studies, orthokeratology was reported to significantly reduce axial elongation relative to a control (single-vision distance) intervention. 24 While this technique shows promise as an intervention for reducing childhood myopia progression, there are several important limitations to the existing research evidence. To date, most studies have been single-site trials, involving relatively small numbers of participants (n = 40-50 per group) of predominantly Asian ethnicity, and have evaluated the efficacy of orthokeratology over a two-year period; there is a dearth of longer-term prospective data to inform the longevity of effects.…”

Section: Discussionmentioning

confidence: 99%

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Knowledge, perspectives and clinical practices of Australian optometrists in relation to childhood myopia

Douglass

Keller

et al. 2020

Clinical and Experimental Optometry

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Background The aim was to investigate the understanding of Australian optometrists in relation to myopia, its natural history and associations with vision‐threatening ocular disease, self‐reported clinical diagnosis and management approaches for childhood myopia, engagement with adult caregivers, and utilisation of information to guide practice. Methods An online survey was distributed to Australian optometrists (n = 4,124). Respondents provided information about their demographics (for example, gender, age, practice location and modality), myopia knowledge, self‐reported practice behaviours relating to childhood myopia, the information and evidence base used to guide their practice, and perceived extent of adult caregiver engagement in making management decisions for myopic children. Results Completed surveys were returned by 239 optometrists (six per cent completed response rate). Most respondents demonstrated knowledge of the association between high myopia and retinal breaks, retinal detachment and primary open‐angle glaucoma. Optometrists used a range of techniques to diagnose childhood myopia, with a preference for non‐cycloplegic refractive measures. The most common approaches to management were single‐vision distance and progressive addition spectacle lenses, despite most optometrists identifying orthokeratology, low‐dose (0.01%) topical atropine and soft peripheral defocus contact lenses as three potentially more effective therapeutic interventions for modifying childhood myopia progression. Almost 90 per cent of respondents considered increasing time spent outdoors to be beneficial for reducing the rate of myopia progression. The main sources of information used to guide clinical practice were continuing education conferences and events, systematic reviews, and personal experience. Respondents perceived adult caregivers to generally be involved in myopia management decisions, and considered all aspects of myopia education as important. Conclusion Current optometric practices reflect the inconclusive nature of several key aspects of the evidence for childhood myopia management. Australian optometrists appear aware of emerging evidence, but are not routinely adopting measures that have not yet received regulatory approval for modulating childhood myopia progression. Clinical guidelines may be of value for assisting practitioners in making clinical decisions based upon the current, best‐available research evidence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Knowledge, perspectives and clinical practices of Australian optometrists in relation to childhood myopia

Douglass

Keller

et al. 2020

Clinical and Experimental Optometry

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“…In recent years, many groups have reported the efficacy of various treatments in reducing progression of myopia, such as atropine eyedrops[8,9], orthokeratology[10,11], and specialized contact lens[12]. However, all these treatment options may suffer potentially severe side effects [8,13], and thus may raise challenges in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Identifying Children at Risk of High Myopia Using Population Centile Curves of Refraction

et al. 2016

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PurposeTo construct reference centile curves of refraction based on population-based data as an age-specific severity scale to evaluate their efficacy as a tool for identifying children at risk of developing high myopia in a longitudinal study.MethodsData of 4218 children aged 5–15 years from the Guangzhou Refractive Error Study in Children (RESC) study, and 354 first-born twins from the Guangzhou Twin Eye Study (GTES) with annual visit were included in the analysis. Reference centile curves for refraction were constructed using a quantile regression model based on the cycloplegic refraction data from the RESC. The risk of developing high myopia (spherical equivalent ≤ -6 diopters [D]) was evaluated as a diagnostic test using the twin follow-up data.ResultsThe centile curves suggested that the 3rd, 5th, and 10th percentile decreased from -0.25 D, 0.00 D and 0.25 D in 5 year-olds to -6.00 D, -5.65D and -4.63 D in 15 year-olds in the population-based data from RESC. In the GTES cohort, the 5th centile showed the most effective diagnostic value with a sensitivity of 92.9%, a specificity of 97.9% and a positive predictive value (PPV) of 65.0% in predicting high myopia onset (≤-6.00D) before the age of 15 years. The PPV was highest (87.5%) in 3rd centile but with only 50.0% sensitivity. The Mathew’s correlation coefficient of 5th centile in predicting myopia of -6.0D/-5.0D/-4.0D by age of 15 was 0.77/0.51/0.30 respectively.ConclusionsReference centile curves provide an age-specific estimation on a severity scale of refractive error in school-aged children. Children located under lower percentiles at young age were more likely to have high myopia at 15 years or probably in adulthood.

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“…S. Li и соавт. [34] в 2016 г. в своем метаанализе на основе 3 рандомизированных контролируемых исследований (РКИ) и 6 когортных исследований показали, что средняя разница удлинения ПЗО глаза между группой ночных линз и группой контроля через 6 мес, 1 год, 1,5 и 2 года составила 0,13, 0,19, 0,23 и 0,27 мм (р < 0,01) соответственно. J. Si и соавт.…”

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Modern optical methods of peripheral defocus correction

Milash

Епишина

Толорая

2019

Rossijskij oftalʹmologičeskij žurnal

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Экспериментальные исследования на животных представили убедительные доказательства возможности -посредством манипуляции с дефокусом различного знака -замедлять или ускорять рост глаза. Ведущим механизмом в ряде современных оптических стратегий профилактики прогрессирования миопии является наведение (индукция) миопического дефокуса на периферию сетчатки или уменьшение гиперметропического дефокуса. В обзоре проанализированы сведения о периферической рефракции при ортокератологической, мультифокальной контактной и мультифокальной очковой коррекции. Показана эффективность данных методов коррекции в контроле прогрессии миопии у детей и подростков. Ключевые слова: миопия; периферическая рефракция; ортокератология; мультифокальные мягкие контактные линзы; мультифокальные очки; очки «Перифокал» Конфликт интересов: отсутствует. Прозрачность финансовой деятельности: никто из авторов не имеет финансовой заинтересованности в представленных материалах или методах. Для цитирования: Милаш С.В., Епишина М.В., Толорая Р.Р. Современные оптические методы коррекции периферического дефокуса. Российский офтальмологический журнал. 2019; 12 (4): 92-8.Experimental animal studies proved that by manipulating with the defocus one can slow down or speed up the eye growth. The leading mechanism among modern optical strategies of myopia progression treatment is to induce myopic defocus to retinal periphery or decrease the hyperopic defocus. This review sums up the data on peripheral refraction in orthokeratological, multifocal contact, and multifocal spectacle correction. The effectiveness of these methods in myopia control in children and teenagers is shown.

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Efficacy, Safety and Acceptability of Orthokeratology on Slowing Axial Elongation in Myopic Children by Meta-Analysis

Cited by 111 publications

References 32 publications

Knowledge, perspectives and clinical practices of Australian optometrists in relation to childhood myopia

Knowledge, perspectives and clinical practices of Australian optometrists in relation to childhood myopia

Identifying Children at Risk of High Myopia Using Population Centile Curves of Refraction

Modern optical methods of peripheral defocus correction

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