Efficacy, Safety, and Biodegradation of a Degradable Scleral Buckle of Chitosan–gelatin Polymer in Rabbits

Yang, Yumin; Zhu, Rongrong; Chen, Hui

doi:10.1097/iae.0b013e3182733a64

Cited by 6 publications

(1 citation statement)

References 32 publications

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“…Данный материал в настоящее время активно изучается в различных областях науки, в том числе в регенеративной медицине и офтальмологии. Уже исследована возможность использования хитозана в различных агрегатных состояниях для создания транспортных систем доставки лекарственных препаратов и веществ в различные структуры глазного яблока [29], препаратов для хирургического лечения отслойки сетчатки [2,41] и роговицы [8]. Такие природные свойства хитозана, как биосовместимость и биодеградация, низкая токсичность, механическая устойчивость, доступность, позволяют рассматривать его в качестве потенциального материала в создании матрицы для культивации различных типов клеток, в том числе ЛЭСК.…”

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Current approaches to the problem of carrier selection for limbal stem cells cultivation in the treatment of limbal stem cell deficiency

Kulikov

Николаевич²,

Churashov

et al. 2018

Ophthalmology Reports

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Diseases and damages of the ocular surface are one of the common causes of decreased vision and blindness. Dysfunction or death of limbal epithelial stem cells (LESC) plays an important role in the development of pathological processes in these conditions, which leads to the development of the limbal stem cell deficiency (LSCD). Currently, one of the methods to treat LSCD is a transplantation of cultured ex vivo LESC. The most common carriers for the cultivation of LESC in the world is the amniotic membrane (AM). However, the presence of certain disadvantages in using AM for the cultivation of LESC compels to search new types of carriers made from biological or synthetic materials. In this review, we have analyzed various types of carriers: collagen, fibrin, chitosan with gelatin, silk fibroin, keratin, contact lenses, polylactide-co-glycolide, polycaprolactone, and the possibility of their application as carriers for the LESC cultivation followed by transplantation on the ocular surface is considered.

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Current approaches to the problem of carrier selection for limbal stem cells cultivation in the treatment of limbal stem cell deficiency

Kulikov

Николаевич²,

Churashov

et al. 2018

Ophthalmology Reports

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Response of Gelatin Modified Electrode towards Sensing of Different Metabolites

Rawat

Solanki

Arora

et al. 2014

Appl Biochem Biotechnol

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In this study, a very thin film of biocompatible gelatin B (GB) fabricated onto indium tin oxide (ITO)-coated glass substrate for electrochemical catalytic activity towards different metabolites has been investigated. The optical and electrochemical properties of bare GB/ITO electrode and with different metabolites were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and electrochemical techniques. The optical properties clearly indicate the structural and surface morphological changes on electrode surface. FTIR spectra showed displacement of the IR peaks towards smaller wave numbers, indicating possible existence of hydrogen bonding between the GB and metabolites. The catalytic behaviour of GB/ITO electrode towards ascorbic acid (AA), citric acid (CA), oxalic acid (OA), glucose (Glu), sucrose (Suc), lactose (Lac) and fructose (Fru) has been investigated by cyclic voltammetry (CV). The electrochemical response studies of GB/ITO electrode have been monitored with different metabolites in the range of 10-500 mg/dl. The sensitivity of GB/ITO electrode for AA and OA was found as 0.156 and 0.108 μA/(mg/dl cm(-2)) respectively. The results indicate that the GB/ITO electrode has higher specificity towards the AA and OA. The attractive properties of GB/ITO electrode provide the potential applications in the simultaneous detection of AA and OA. The excellent electrocatalytic behaviour of GB/ITO electrode may be useful towards the construction of electrochemical biosensors.

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The ocular pharmacokinetics and biodistribution of phospho-sulindac (OXT-328) formulated in nanoparticles: Enhanced and targeted tissue drug delivery

Wen

Muratomi

Huang

et al. 2019

International Journal of Pharmaceutics

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Efficacy, Safety, and Biodegradation of a Degradable Scleral Buckle of Chitosan–gelatin Polymer in Rabbits

Abstract: Chitosan-gelatin polymer was used effectively and safely as an implant for scleral buckling in a rabbit and showed good biodegradation.

Cited by 6 publications

References 32 publications

Current approaches to the problem of carrier selection for limbal stem cells cultivation in the treatment of limbal stem cell deficiency

Current approaches to the problem of carrier selection for limbal stem cells cultivation in the treatment of limbal stem cell deficiency

Response of Gelatin Modified Electrode towards Sensing of Different Metabolites

The ocular pharmacokinetics and biodistribution of phospho-sulindac (OXT-328) formulated in nanoparticles: Enhanced and targeted tissue drug delivery

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