Efficacy, Safety, and Interactions of a Live Infectious Bursal Disease Virus Vaccine for Chickens Based on Strain IBD V877

Abstract

Infectious bursal disease (IBD) is a highly contagious disease in young chickens which can result in high morbidity and mortality and also in great economic losses. The main target for the virus is the lymphoid tissue with a special predilection for the bursa of Fabricius. Several vaccines are available to control the disease. Intermediate plus vaccines are used in chickens with high maternal antibody titers which face high infection pressure. An example of an intermediate plus vaccine is a live vaccine based on IBD strain V877. The results of an efficacy study in commercial broilers with different levels of maternally derived antibodies (MDA) showed that the V877-based IBD vaccine can break through maternal antibody titers of higher than 1100 as determined by an IBD ELISA. The safety of the vaccine was demonstrated in a study in which specific-pathogen-free (SPF) chickens were vaccinated with a tenfold dose of the vaccine strain and a tenfold dose of the vaccine strain after five back passages in SPF chickens. The vaccine virus caused lesions, as could be expected for an intermediate plus vaccine, but the scores were not much higher than the maximal scores allowed for mild IBD vaccines in the European Pharmacopoeia, and reversion to virulence was absent. In studies in SPF chickens, there were no negative impacts by the IBD V877 vaccine on the efficacy of a live QX-like IB vaccine and a live Newcastle disease La Sota vaccine in vaccination challenge studies, although the IBD vaccine had a negative effect on the antibody response generated by the QX-like IB vaccine. It is concluded that the IBD V877 vaccine has the capacity to break through high levels of MDA, has a satisfactory safety profile, and interactions with other live vaccines are limited. In order to limit bursal lesions after vaccination it is recommended to confirm the presence of MDA before vaccinating with the V877 vaccine.

Histopathology and Serology Reaction to an Immune Complex Infectious Bursal Disease Vaccine (V877 Strain) in SPF and Commercial Birds

“…Furthermore, in subsequent evaluations after 35 and 42 days, the score showed a tendency to drop to 2.00 and 1.83, clearly demonstrating the regenerative capacity of lymphoid follicles (Table 1 and Figure 5). These results support the use of this V877 strain (GEERLIGS et al, 2015) as a safe vaccine candidate. This regeneration capacity of the lymphoid follicles is related to the integrity of the basement membrane that makes the lining of the follicles where the presence of preserved follicular dendritic cells was observed in the histopathological assessment of vaccinated birds.…”

Characterization of antigenic variant infectious bursal disease virus strains identified in South Korea

“…Immunisation of broiler chicks with intermediate or intermediate-plus strains and immunisation of breeders with live attenuated/inactivated vaccines is widely used to control IBDV infection worldwide. However, IBD outbreaks in vaccinated flocks have been documented in several countries (Geerligs et al, 2015). To date, vvIBDV strains have received the most attention because these strains cause acute infection, with high mortality and significant clinical signs.…”

A field study on the evaluation of day-of-hatch and in grow-out application of live infectious bursal disease virus vaccine in broiler chickens

“…Previous reports showed that the induction of humoral immunity clearly correlated with the induction of bursal lesions and IBDV replication while conventional live IBDV vaccine inflicts transient bursal damage increasing the bursal lesion scores in broiler chickens ( Rautenschlein et al, 2003 ; Geerligs et al., 2015 ). In present study, the bursal lesion scores evaluated in trial 1 and 2 showed numerically lower scores in the MB-1 groups vis-à-vis the Icx vaccine and the conventional live vaccine, M.B.…”