A weakly nonlinear generation of non-acoustic modes in the field of sound in a gas is considered. An exoteric chemical reaction of A → B type, which takes place in a gas, may be reversible or not. Two types of sound are considered, low-frequency and high-frequency as compared with the characteristic time of a chemical reaction. For both these cases, the governing equations of non-acoustic modes are derived and conclusions of the efficiency of their nonlinear generation by sound are made. The character of nonlinear generation of non-acoustic modes by sound depends essentially on reversibility of a chemical reaction.