Efficiency of apples, strawberries, and tomatoes for reduction of oxidative stress in pigs as a model for humans

Pajk, T.; Rezar, Vida; Levart, Alenka; Salobir, Janez

doi:10.1016/j.nut.2005.08.010

Cited by 51 publications

(31 citation statements)

References 40 publications

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“…According to data in the literature apples contain more phenols (Jung et al, 2009) and mandarins more vitamin C and specific flavonoids and carotenoids (Sentandreu et al, 2007). This finding is in accordance with that of previous studies in which animals supplemented with different fruits shown different responses in the parameters of oxidative stress (Pajk et al, 2006).…”

Section: Discussionsupporting

confidence: 90%

Dried apple enriched with mandarin juice counteracts tamoxifen-induced oxidative stress in rats

Codoñer‐Franch

Betoret

López-Jaén

et al. 2013

International Journal of Food Sciences and Nutrition

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Codoñer Franch, P.; Betoret Valls, ME.; López Jaén, AB.; Betoret Valls, N.; Fito Maupoey, P.; Valls Bellés, MV. (2013). Dried apple enriched with mandarin juice counteracts tamoxifen induced oxidative stress in rats. International Journal of Food Sciences and Nutrition. 64(7): 815-821. doi:10.3109/09637486.2013.798267. Dried apple enriched with mandarin juice by vacuum impregnation counteracts the liver oxidative effect of tamoxifen in rats. AbstractWe have investigated the effects of a product made of apple dehydrated enriched by vacuum impregnation of mandarin juice in decreasing oxidative stress biomarkers in rat induced liver injury by tamoxifen. A experimental design was undertaken in six groups of animals. One group fed a standard diet. Two groups were supplemented with 0.745 g/d of apples snacks/day either impregnated or not with mandarin juice during 28 days. Three groups of rats were treated with tamoxifen 1.54 mg/kg/day during 21 days; of these, one group was supplemented with the apple snacks and the other with the apple snacks impregnated with mandarin juice. Plasma aminotransferases were determined as index of hepatocellular damage and interleukin-6 as measure of inflammation. Plasma and liver carbonyl groups, indicative of protein oxidation, and α-tocopherol as evaluation of antioxidant defense were measured. The modified base 8-hydroxydexyguanosine as indicative of DNA damage was determined in liver. Tamoxifen induced an increase in aminotranferases and both plasma and liver markers of oxidative stress and DNA damage that decrease significantly after apple snack consumption; in most of cases they even reach normal values as those achieved previous to induce the injury with tamoxifen. The effect of the mandarin juice incorporated to the structure of apple mainly accounts for increasing levels of α-tocopherol in plasma and liver. The present study shown the potential protective action of the products made of dehydrated apple either impregnated or not with mandarin juice by vacuum impregnation for counteracting the chemically induced liver injury in rats.

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Section: Discussionsupporting

confidence: 90%

Dried apple enriched with mandarin juice counteracts tamoxifen-induced oxidative stress in rats

Codoñer‐Franch

Betoret

López-Jaén

et al. 2013

International Journal of Food Sciences and Nutrition

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“…These effects are physiologically relevant as they were induced by a daily supplement equivalent to 275 ml of beverage consumed on a daily base by a 70 kg human. There are reports that consumption of fruit juice and green tea both increase the activity of hepatic antioxidant enzymes (Lin et al, 1998;Pajk et al, 2006). This contrasts with the findings of the present study where berry juice and tea consumption lowered hepatic GSHPx and SOD activities, and agree with previous results in hamsters receiving either pure catechin, quercetin or resveratrol (Auger et al, 2005 a) or phenolics from purple grape, apple, purple grape juice and apple juice (Décordé et al, 2008).…”

Section: Discussionsupporting

confidence: 80%

“…A decreased activity of antioxidant enzymes may be a consequence of the sparing effect of dietary antioxidants, reducing the requirement for enzymatic antioxidant function when elevated concentrations of exogenous antioxidants are present in the circulatory system (Breinholt et al, 1999). Elsewhere, spontaneous hepatic lipid peroxidation has been shown to decrease with an increasing level of dietary antioxidants (Leibovitz et al, 1990), and supplementation with apples effectively decreases oxidative stress by decreasing malondialdehyde formation in the body (Pajk et al, 2006). In this study (Décordé et al, 2008), hepatic TBARS concentration decreased in each group.…”

Section: Discussionmentioning

confidence: 61%

Dietary Antioxidants: From Micronutrients and Phytochemicals to Enzymes - Preventive Effects on Early Atherosclerosis and Obesity

Gaillet¹,

La²,

Rouanet³

2012

Oxidative Stress - Environmental Induction and Dietary Antioxidants

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“…They are excellent as free radical scavengers including those in the form of the reactive forms of oxygen [Pajk et al, 2006;Skupień et al, 2008]. The radicals are the products of metabolic reactions within the living organism and are also formed in the external medium, e.g.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Extracts from Apple, Chokeberry and Strawberry.

Bonarska-Kujawa

Sarapuk²,

Bielecki³

et al. 2012

Pol. J. Food Nutr. Sci.

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The aim of the study was to determine the protective action of extracts from apple, strawberry and chokeberry with respect to linoleic acid and the biological membrane exposed to oxidation induced by physicochemical factors. The activity of the extracts was determined by measuring inhibition of lipid oxidation in red blood cell membrane, induced with UVC radiation and the AAPH radical. The protective effect of the extracts was essayed fl uorimetrically and spectrophotometrically. These results together with the ones obtained earlier explain the mechanism of the interaction between the extracts and the red blood cell membrane. The mechanism consists in the incorporation into the membrane and screening the cell against oxidation. The results indicate that the extracts possess very good antioxidant properties, since at the highest concentrations used (0.1 mg/mL) they protect the biological membranes almost entirely against oxidation. Among the extracts studied the best antioxidant properties were exhibited by the apple fruit, which gave 80% or 100% protection of the membrane at 0.05 mg/mL concentration of dry matter, for UVC and AAPH inductors, respectively.

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Efficiency of apples, strawberries, and tomatoes for reduction of oxidative stress in pigs as a model for humans

Cited by 51 publications

References 40 publications

Dried apple enriched with mandarin juice counteracts tamoxifen-induced oxidative stress in rats

Dried apple enriched with mandarin juice counteracts tamoxifen-induced oxidative stress in rats

Dietary Antioxidants: From Micronutrients and Phytochemicals to Enzymes - Preventive Effects on Early Atherosclerosis and Obesity

Antioxidant Activity of Extracts from Apple, Chokeberry and Strawberry.

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