Efficiency of Fenbendazole on the Basis of Nanosized Supramolecular Delivery Systems with Polyvinyl Pyrrolidone and Dioctylsulphosuccinate Sodium in the Cases of Helminthosis

Abstract

Цель исследований: изучение эффективности фенбендазола на основе наноразмерной супрамолекулярной системы доставки с поливинилпирролидоном и диоктилсульфосукцинатом натрия при гельминтозах животных. Материалы и методы. Опыты проводили на 120 мышах, экспериментально зараженных Trichinella spiralis, Hymenolepis nana и овцах, спонтанно зараженных желудочно-кишечными нематодами (120 гол.) и мониезиями (60 гол.). При каждом гельминтозе животным разных групп по 10 гол. в каждой задавали однократно перорально супрамолекулярный комплекс фенбендазола (СМКФ) с поливинилпирролидоном (ПВП) и диоктилсульфосукцинатом натрия (ДССН) в дозах 3,0; 2,0 и 1,0 мг/кг по ДВ в сравнении с базовым препаратом фенбендазолом в дозе 2,0 мг/кг. Контролем служила группа животных, не получавшая препарат. Эффективность препаратов учитывали по результатам вскрытий кишечника мышей и данным копроовоскопических исследований овец методом флотации до и через 15 сут после введения препаратов.

Innovative anthelmintic based on mechanochemical technology and their efficacy against parasitic infection of sheeps

“…In the experiments carried out, the preparations obtained by the methods of mechanical processing of the FBZ, TBZ, Iver substances with PVP were tested. It is known that in recommended doses, Iver is highly effective and has a broad parasiticidal spectrum against nematodes mites and insects, FBZ against nematodes and cestodes, TBZ against trematodes [ 16 – 18 ]. The above-mentioned antiparasitic substances after joint mechanical treatment with polymers gives the possibility to obtain SD with significantly increase the solubility of these substances.…”

Solid Dispersions of Biologically Active Substances

“…FBZ was also mechanically modified with AG and the resulting SD, had an increased (18 times) solubility and in a reduced dose of 3.0 mg / kg for AS shows 100% efficiency in Dictyocaulosis, Strongyloidosis and Strongylatosis of the digestive tract and 98,3% activity in sheeps Trichocephalosis [43], while the recommended dose of the standard drug is 5.0 mg / kg of AS. But SD of FBZ with PVP and DSS of had the solubility increased up to 24 times, which made it possible to achieve 100% efficiency in Trichinosis and Hymenolepiasis in white mice and gastrointestinal Strongylatosis and Moniesiasis in sheeps at a dose of 2.0 and 3.0 mg / kg, which is lower than the recommended dose of the standard drug [44].…”

Solid Dispersions of Anthelmintics and Plant Protection Preparations

“…FBZ was also mechanically modified with AG and the resulting SD had an increased (in 18 times) solubility and a reduced dose of 3.0 mg/kg for AS shows 100% efficiency in Dictyocaulosis, Strongyloidosis, and Strongylatosis of the digestive tract and 98.3% activity in sheep Trichocephalosis [55], while the recommended dose of the standard drug is 5.0 mg/kg of AS (Table 1). However, the SD of FBZ with PVP and DSS had the solubility increased up to 24 times, which made it possible to achieve 100% efficiency in Trichinosis and Hymenolepiasis in white mice and gastrointestinal Strongylatosis and Moniesiasis in sheep at a dose of 2.0 and 3.0 mg/kg, which is lower than the recommended dose of the standard drug [56].…”