The quality of cow’s milk and the spread of mastitis greatly depend on the level of udder hygiene. Our author’s research was conducted to evaluate the effects of Forticept® Udder Wash and Forticept® Udder Forte, used before and after milking, on the treatment and prevention of subclinical mastitis and hyperkeratosis of cows’ udders. A total of 6880 milk samples were taken from 430 cows, 3-4 years old, 470-490 kg weight, at 60 ± 15 days of lactation. The therapeutic efficacy coefficient (EC) of Forticept® polymers based on benzetonium and benzalkonium chloride, against the subclinical form of mastitis was 73.8% compared to iodine-containing agents; preventive EC - 32.4%. Dipping hygiene of the udder using Forticept® on the 30th day reduced the number of 1-3 stage teat hyperkeratosis cases from 78.8% to 41.3%. Also, during this period, a significant (P<0.05) improvement in the chemical parameters of the milk was observed - an increase in fat (up to 3.94 ± 0.08%), protein (3.35 ± 0.07%), casein (3.15 ± 0.09%) and dry matter (14.91 ± 0.28%). After using Forticept®, the total bacteria count (TBC) of the milk decreased to 3×105 CFU/cm3, and the somatic cell count (SCC) - to 130 thousand/cm3 (P<0.05). Test day milk yield (TDMY) increased by 1.15% due to efficient dipping with Forticept® (P<0.05).