Efficiency of soft tissue incision with a novel 445-nm semiconductor laser

Braun, Andreas; Kettner, Moritz; Berthold, Michael; Wenzler, Johannes-Simon; Heymann, Paul; Frankenberger, Roland

doi:10.1007/s10103-017-2320-9

Cited by 50 publications

(37 citation statements)

References 22 publications

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“…At present, few in vivo studies have been conducted with this wavelength, therefore it was not possible to compare the data obtained with similar devices [40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Histological Effects of an Innovative 445 Nm Blue Laser During Oral Soft Tissue Biopsy

Palaia

Pergolini

D’Alessandro

et al. 2020

IJERPH

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Continuously evolving laser devices can be used in various fields; they are an alternative to the traditional cold blade surgery to perform biopsies of oral soft tissues. The aspect focused on in this paper is the possibility to use the 445 nm diode laser (Eltech K-Laser srl, Treviso, Italy) in complete safety, by evaluating its thermal effects during microscopy. A histological evaluation of the alteration of the peri-incisional edges on 10 samples was realized. All excisional biopsies were related to clinically unsuspected lesions and performed by the same expert operator. The surgical procedure was performed with the same laser parameters and the same pathologist evaluated the thermal effect on the samples. An average value of the detected tissue alteration was calculated; the average damage of the epithelium was 650.93 μm, while in the connective tissue it was 468.07 μm. In all the cases a clear diagnosis was possible, and no clinical complications were observed; so, the 445 nm diode laser proved to be a device that can be safely used for biopsies of clinically unsuspicious lesions. Due to the small number of cases, this in vivo preliminary experience needs to be extended.

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“…At present, few in vivo studies have been conducted with this wavelength, therefore it was not possible to compare the data obtained with similar devices [40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Histological Effects of an Innovative 445 Nm Blue Laser During Oral Soft Tissue Biopsy

Palaia

Pergolini

D’Alessandro

et al. 2020

IJERPH

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“…20 Several reports about blue laser and tissue interaction were mainly focused on the oral tissue in vitro experiments and resection of benign oral lesions. Comparing with traditional infrared diode laser and quantic molecular resonance scalpel, LED blue laser demonstrated excellent cutting property [6][7][8]21 in assessed lasertissue interactions in monolayer cultures. In addition, except the high cutting property of the 450 nm blue laser, the novel blue LED laser system used in this study is compact and portable, another advantage of LED blue laser.…”

Section: Discussionmentioning

confidence: 97%

“…6 Recently, novel blue lasers whose wavelengths were 450 and 445 nm have been introduced in stomatology, and the tissue incision and laser-tissue interaction were evaluated. 7,8 Comparing with traditional lasers applied to esophageal and gastrointestinal tissue, blue laser possesses vital superiorities of shorter wavelength and higher absorption coefficient in the target chromophores hemoglobin and melanin, and its optical penetration depths of human colon mucosa/ submucosa are less deep. 9 In the previous studies, blue laser presented favorable vaporization and coagulation results and appeared to be an emerging surgical tool applied to the mucosal and submucosal lesions.…”

Section: Introductionmentioning

confidence: 99%

“…9 In the previous studies, blue laser presented favorable vaporization and coagulation results and appeared to be an emerging surgical tool applied to the mucosal and submucosal lesions. 7,8 Since the thickness of human colonic wall is no more than 1 mm, 10 the low-power blue laser, which could be precisely controlled, vaporize tissue less deeply, and make good vessel coagulation, could be an excellent and safe tool for colonic surgery; however, whether blue laser can be applied in colonic surgery has not been reported.…”

Section: Introductionmentioning

confidence: 99%

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A Novel 450 nm Semiconductor Blue Laser System for Application in Colon Endoscopic Surgery: An Ex Vivo Study of Laser–Tissue Interactions

Jiang

Liu

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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Objective: Our study aimed to detect whether 450 nm blue laser can be applied effectively and safely in endosocopic submucosal dissection (ESD) system for surgery in colonic tissue. Background data: Semiconductor blue laser has been applied in surgery due to its excellent cutting property, however, whether blue laser can be applied in colonic surgery has not been reported. Materials and methods: Porcine colon tissues were vaporized by 450 nm blue semiconductor laser at 10-25 W and at working distances from 0.5 to 3 mm, with a three-dimensional scanning system. Moreover, we designed an ESD model and applied blue laser at 10 W on porcine colonic tissues with this system. Dimensions of the vaporized tissues and coagulation zones were assessed under microscopy. Results: Since the thickness of colonic wall is no more than 1 mm, first we determined the cutting property and safety of blue laser on porcine colon tissue and found that blue laser at 10 W made lesions shallower than 1 mm and the depth of vaporization can be controlled effectively within muscularis mucosa and submucosa. Moreover, a large scale of porcine colonic tissue was vaporized precisely by blue laser at power of 10 W with the ESD system ex vivo. Conclusions: Our results indicate that 450 nm blue laser at 10 W can be well controlled for laser-tissue interaction with excellent cutting efficiency and less thermal damage in adjacent tissues especially side of the submucosa. Therefore, 450 nm semiconductor blue laser could be a safe alternative approach for colonic surgery.

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“…It is based on the Amdt–Schutz principle. [ 22 23 ] In a dental laser, the unit comprises an active lasing medium, and two mirrors and an energy source. For a dental laser, the light from the unit reaches the tissue either by a fiber optic cable, hollow waveguide, or a cooling system.…”

Section: Introductionmentioning

confidence: 99%

Applications of lasers in refractory periodontitis: A narrative review

Varma

AlShayeb

Narayanan

et al. 2020

J Int Soc Prevent Communit Dent

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A BSTRACT Objective: The purpose of the study is to evaluate the various lasers in dentistry and to investigate if it can be used for treatment of refractory periodontitis. Methods: The study followed partially the PRISMA guidelines as it is a narrative review. A number of articles were selected from a period of 1980 to 2020 from databases, PubMed, PubMed central, Cochrane and Scopus. Articles related to the effects of lasers on periodontitis both refractory and aggressive were investigated. Results: After reviewing the literature, 70 articles were found, related to application of lasers in periodontal diseases. Out of the 70, 11 articles pertained to the effect of laser for the treatment of Refractory and inflammatory periodontitis. 5 articles related to experimental animal models, one pertaining to in-vitro and six studies related to in-vivo in human cohorts. Discussion: It was found that lasers if used in controlled parameters by incorporating laser assisted treatment such as Photodynamic therapy and low level laser therapy can be of use as an adjunct therapy for treatment of refractory periodontitis. The use of different wavelengths in the initial and maintenance phase of periodontal disease plays a positive role. The presence of in-vitro and animal model studies is one of the limitation to this study. The available studies have shown marked reduction in inflammation and better clinical and microbiological parameters. The drawback of this study is the limited literature involving laser management for refractory periodontitis in human cohorts. Conclusion: Different wavelengths of laser and choice of laser assisted periodontal treatment plays an important role in the overall progress and prognosis of periodontal disease activity.

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Efficiency of soft tissue incision with a novel 445-nm semiconductor laser

Cited by 50 publications

References 22 publications

Histological Effects of an Innovative 445 Nm Blue Laser During Oral Soft Tissue Biopsy

Histological Effects of an Innovative 445 Nm Blue Laser During Oral Soft Tissue Biopsy

A Novel 450 nm Semiconductor Blue Laser System for Application in Colon Endoscopic Surgery: An Ex Vivo Study of Laser–Tissue Interactions

Applications of lasers in refractory periodontitis: A narrative review

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