Efficient Adsorption of Doxycycline Hydrochloride Using Deep Eutectic Solvent Functionalized Activated Carbon Derived from Pumpkin Seed Shell

Kaur, Gurleenjot; Singh, Neetu; Rajor, Anita

doi:10.1002/slct.202100182

Cited by 13 publications

(6 citation statements)

References 47 publications

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“…Likewise, DOX in neutral pH is a zwitterion consisting of positive and negatively charged functional groups. [ 15 ] Thereby, DOX can interact with SNs electrostatically via the positively charged NH 3 + groups and negatively charged carboxylic groups present in DOX interacting with the negative surfaces and positive edges of SNs, respectively. To confirm the effect of DOX additives on hydrogels’ net charges, the zeta potential of the hydrogels was measured (Figure 2B).…”

Section: Resultsmentioning

confidence: 99%

Injectable Shear‐Thinning Hydrogels with Sclerosing and Matrix Metalloproteinase Modulatory Properties for the Treatment of Vascular Malformations

Zehtabi,

Gangrade,

Tseng

et al. 2023

Adv Funct Materials

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Sac embolization of abdominal aortic aneurysms (AAAs) remains clinically limited by endoleak recurrences. These recurrences are correlated with recanalization due to the presence of endothelial lining and matrix metalloproteinases (MMPs)‐mediated aneurysm progression. This study incorporates doxycycline (DOX), a well‐known sclerosant and MMPs inhibitor, into a shear‐thinning biomaterial (STB)‐based vascular embolizing hydrogel. The addition of DOX is expected to improve embolizing efficacy while preventing endoleaks by inhibiting MMP activity and promoting endothelial removal. The results show that STBs containing 4.5% w/w silicate nanoplatelet and 0.3% w/v of DOX are injectable and have a twofold increase in storage modulus compared to those without DOX. STB‐DOX hydrogels also reduced clotting time by 33% compared to untreated blood. The burst release of DOX from the hydrogels show sclerosing effects after 6 h in an ex vivo pig aorta model. Sustained release of DOX from hydrogels on endothelial cells shows MMP inhibition (approximately an order of magnitude larger than control groups) after 7 days. The hydrogels successfully occlude a patient‐derived abdominal aneurysm model at physiological blood pressures and flow rates. The sclerosing and MMP inhibition characteristics in the engineered multifunctional STB‐DOX hydrogels may provide promising opportunities for the efficient embolization of aneurysms in blood vessels.

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Section: Resultsmentioning

confidence: 99%

Injectable Shear‐Thinning Hydrogels with Sclerosing and Matrix Metalloproteinase Modulatory Properties for the Treatment of Vascular Malformations

Zehtabi,

Gangrade,

Tseng

et al. 2023

Adv Funct Materials

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“…In proportion to its complicated structure and good solubility, DOX exhibits high residual toxicity in the aquatic environment. Due to the high solubility of DOX in water, it contaminates the water bodies and increases antimicrobial resistance of microorganisms (Kaur et al 2021b). There is a need to find the suitable process for the removal of DOX present in the wastewater.…”

Section: Introductionmentioning

confidence: 99%

Removal of doxycycline hydrochloride from aqueous solution by rice husk ash using response surface methodology and disposability study

Kaur

Singh

Rajor

et al. 2022

Environ Sci Pollut Res

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The huge demand and consumption of DOX, its incomplete metabolism, and complex behavior in atmosphere are causing a great ecological issue, which needs to be solved. In the present study, the suitability of rice husk ash (RHA) for the greater sorption efficiency of DOX antibiotic was investigated. Furthermore, disposability study of exhausted RHA was performed using solidification technique and leachate had undergone toxicity test to evaluate the DOX encapsulation ability. The central composite design under RSM was employed for the design of experiment and optimization of adsorption parameters. RHA was characterized using various techniques such as XRD, SEM (EDX), FTIR, BET, and zeta potential analysis. The influence of various adsorption parameters, like initial DOX concentration (C 0 ), RHA dosage (m), incubation-time period (t), and pH were examined on the performance in terms of DOX elimination % (X 1 ) and adsorptive capacity (mg/g) (X 2 ). At optimized conditions, the obtained X 1 and X 2 were 98.85% and 17.74 mg/g, respectively. Moreover, the kinetics data suited well to the pseudo-second-order model. Freundlich, Langmuir, and Redlich-Peterson (R-P) isotherm models were applied, out of which Langmuir model best performed under optimized conditions; m = 5 g/L, t = 85.85 min, DOX concentration = 89.73 mg/L, and pH = 6. The bacterial toxicity test of leachate confirmed complete encapsulation of DOX by solidification technique.

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“…It turned out that CO DESs pretreatment improved nanofibrillation of RFs with low hemicellulose content substantially [ 43 ]. Kaur et al [ 18 ] prepared choline chloride-based DESs as a functionalization agent for activated carbon derived from pumpkin seed shell for the uptake of doxycycline hydrochloride (DOX). Hussin et al [ 17 ] studied the modification of low-cost biomass-based activated carbon with DESs to achieve high CO 2 adsorption capacity, and a maximum adsorption capacity of 11.05 mg g −1 was attained at lower temperature.…”

Section: Introductionmentioning

confidence: 99%

Adsorption behavior of Cr(VI) by biomass-based adsorbent functionalized with deep eutectic solvents (DESs)

Huang

Pan

et al. 2022

BMC Chemistry

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This study was aimed to evaluate the performance of DESs functionalized peanut shell (PSD) as biosorbent for removing Cr(VI) from water. The effects of pretreatment, initial concentration, adsorption temperature, kinetics, adsorption isotherm, and thermodynamics were investigated. Scanning electron microscopy (SEM) and Point of Zero charge (pHpzc) techniques were used for characterization of the adsorbents. The results showed that the rigid structure of peanut shell was broken down after DESs modification and the point of zero charge was 6.02 for peanut shell and 6.84 for PSD, which exhibited a slightly acid character. Based on the comparisons of linear and nonlinear analysis of four kinetic models and four isotherms, the pseudo-second-order kinetic model was found to be suitable for describing the adsorption process. The presence of a boundary effect was observed within the range of research, indicating that internal diffusion was not the only rate-controlling step. The equilibrium data were well represented by the Langmuir model rather than the Freundlich, Temkin, and Dubinin–Radushkevich models. The maximum capacity derived was 5.36 mg g−1. Changes in Gibb’s free energy, enthalpy, and entropy revealed that Cr(VI) adsorption onto modified peanut-shell powders was a spontaneous and endothermic process. However, the highest desorption efficiency was only 8.77% by using NaOH as a desorbing agent. Graphical abstract

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Efficient Adsorption of Doxycycline Hydrochloride Using Deep Eutectic Solvent Functionalized Activated Carbon Derived from Pumpkin Seed Shell

Cited by 13 publications

References 47 publications

Injectable Shear‐Thinning Hydrogels with Sclerosing and Matrix Metalloproteinase Modulatory Properties for the Treatment of Vascular Malformations

Injectable Shear‐Thinning Hydrogels with Sclerosing and Matrix Metalloproteinase Modulatory Properties for the Treatment of Vascular Malformations

Removal of doxycycline hydrochloride from aqueous solution by rice husk ash using response surface methodology and disposability study

Adsorption behavior of Cr(VI) by biomass-based adsorbent functionalized with deep eutectic solvents (DESs)

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