Efficient and Convenient Protocol for the Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles Using HClO₄-SiO₂ as a Heterogeneous Recyclable Catalyst

Abstract

General experimental procedure for the synthesis of 3,5disubstituted 1,2,4-oxadiazoles (5a-5n) 3 3 Synthesis of 3,5-disubstituted 1,2 4-oxadiazoles and characterization data (5a-5n) 4 4 1 H, 13 C NMR spectra of new compounds 16 5 References 28

A review on synthetic account of 1,2,4-oxadiazoles as anti-infective agents

“…Nowadays, there are a few commercially available drugs containing 1,2,4-oxadiazole nucleus [ 25 ] such as pleconaril (anti-infective) [ 26 ], oxolamine (anti-inflammatory) [ 27 ], prenoxdiazine (cough suppressant), butalamine (vasodilator) [ 28 ], ataluren (use in Duchenne muscular dystrophy) [ 29 ] and proxazole (used for anti-tussive and anti-plasmodic) [ 30 ] (Fig. 2 ).…”

Recent progress in the synthesis of azoles and related five‐membered ring heterocycles using silica‐supported heterogeneous catalysts

“…The reaction was completed within a very short time. From the reusability test for the particular catalyst, it was found that the catalyst can be used three times without much loss in the yield of the products (Scheme 22) [39]. The catalyst lost the water of crystallization at around 200 C. The strong acid sites of the catalyst were analyzed from the potentiometric titration curve.…”