Efficient anticarcinogenic activity of α-Fe2O3 nanoparticles: In-vitro and computational study on human renal carcinoma cells HEK-293

Abbas, Gulam; Singh, Kijay Bahadur; Kumar, Niraj; Shukla, Anamika; Kumar, Devesh; Pandey, Gajanan

doi:10.1016/j.mtcomm.2021.102175

Cited by 9 publications

(12 citation statements)

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“…The coordination complex was validated as the absorption peak was identified at 390 nm using the UV/visible spectral analysis of the synthesized SRLe -αFe 2 O 3 NPs ( Figure 7 A). Our result coincides with previously published results [ 38 , 39 ]. Additionally, the single and strong peak at 390 nm in the UV/Vis absorption spectrum confirmed that the SRLe -αFe 2 O 3 NPs had a spherical shape, similar to the findings of Kumar et al (2022) [ 40 ].…”

Section: Resultssupporting

confidence: 94%

In Situ Biosynthesis of Reduced Alpha Hematite (α-Fe2O3) Nanoparticles by Stevia Rebaudiana L. Leaf Extract: Insights into Antioxidant, Antimicrobial, and Anticancer Properties

et al. 2022

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In the present study, we utilized Stevia rebaudiana L. (SRLe) extract to in situ biosynthesize nanoscale alpha hematite (α-Fe 2 O 3 ) nanoparticles (NPs) with potent antioxidant, antimicrobial, and anticancer properties. SRLe-α-Fe 2 O 3 was characterized using physiochemical analyses, including UV/Vis, FTIR, XRD, DLS, EDX, SEM, and TEM studies. Among tested solvents, CHCl 3 /MeOH (2:1 v / v ) SRL extract (least polar solvent) contained the highest EY, TPC, and antioxidant capacity of ~3.5%, ~75 mg GAE/g extract, and IC 50 = 9.87 ± 0.7 mg/mL, respectively. FTIR confirmed the engagement of coating operation to the colloidal α-Fe 2 O 3 NPs. TEM, SEM, and DLS revealed that SRLe-α-Fe 2 O 3 has a spherical shape, uniform size distribution with aggregation for an average size of ~18.34 nm, and ζ = −19.4 mV, forming a repulsive barrier that helped to improve stability. The synthesized nanoparticles displayed considerable antibacterial activity against E. coli and S. aureus bacterial growth, and exhibited superior activity against the A549 lung cancer cell lines. These findings indicate that the increased availability of bioactive substances with antioxidant properties of SRLe makes it a potentially interesting material for the preparation of biologically active compounds and green synthesis of nanoparticles.

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Section: Resultssupporting

confidence: 94%

In Situ Biosynthesis of Reduced Alpha Hematite (α-Fe2O3) Nanoparticles by Stevia Rebaudiana L. Leaf Extract: Insights into Antioxidant, Antimicrobial, and Anticancer Properties

et al. 2022

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“…The absorption bands in the fingerprint region at 665 and 573 cm –1 are due to the Fe–O interaction of α-Fe 2 O 3 NPs. 48 , 56…”

Section: Resultsmentioning

confidence: 99%

Fabrication of α-Fe₂O₃ Nanostructures: Synthesis, Characterization, and Their Promising Application in the Treatment of Carcinoma A549 Lung Cancer Cells

et al. 2022

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In the present work, iron nanoparticles were synthesized in the α-Fe 2 O 3 phase with the reduction of potassium hexachloroferrate(III) by using l -ascorbic acid as a reducing agent in the presence of an amphiphilic non-ionic polyethylene glycol surfactant in an aqueous solution. The synthesized α-Fe 2 O 3 NPs were characterized by powder X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, atomic force microscopy, dynamic light scattering, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, and ultraviolet–visible spectrophotometry. The powder X-ray diffraction analysis result confirmed the formation of α-Fe 2 O 3 NPs, and the average crystallite size was found to be 45 nm. The other morphological studies suggested that α-Fe 2 O 3 NPs were predominantly spherical in shape with a diameter ranges from 40 to 60 nm. The dynamic light scattering analysis revealed the zeta potential of α-Fe 2 O 3 NPs as −28 ± 18 mV at maximum stability. The ultraviolet–visible spectrophotometry analysis shows an absorption peak at 394 nm, which is attributed to their surface plasmon vibration. The cytotoxicity test of synthesized α-Fe 2 O 3 NPs was investigated against human carcinoma A549 lung cancer cells, and the biological adaptability exhibited by α-Fe 2 O 3 NPs has opened a pathway to biomedical applications in the drug delivery system. Our investigation confirmed that l -ascorbic acid-coated α-Fe 2 O 3 NPs with calculated IC 50 ≤ 30 μg/mL are the best suited as an anticancer agent, showing the promising application in the treatment of carcinoma A549 lung cancer cells.

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“…Recently bio-nanotechnology has been emerging as a new field to play a significant role in the detection, diagnosis, and bio-image target treatment of various diseases including carcinomas . Several nanoparticles have attracted interest for standard carcinoma treatment because of their enhanced permeability, efficient internalization, retention properties, and promising anticarcinoma activity as these cause adverse effects, drug resistance, and higher efficacy for carcinoma treatment . With increasing commercial and therapeutic applications of engineered nanoparticles, the study of their adverse potential effects on public and environmental health has become an important research topic .…”

Section: Introductionmentioning

confidence: 99%

“…Recently, transition-metal complexes containing l -ascorbic acid (LAA) and poly(ethylene glycol) (PEG) derivatives have been reported and used in anticarcinoma activity . Cuprous oxide nanoparticles (β-Cu 2 O NPs) of the cuprite phase have gained special interest among transition-metal oxides because of their efficacy as nanofluids, sensors, antimicrobial applications, catalysts, superconductors, energy storage systems, and anticarcinoma agents. , Studies on the interaction of small molecules with proteins are important for the investigation, morphology, and designing of novel drugs effective against anticarcinoma activity . These β-Cu 2 O NPs can bind with proteins via three types of noncovalent interactions like electrostatic binding, metal groove binding, and intercalation binding modes .…”

Section: Introductionmentioning

confidence: 99%

One-Pot Surface Modification of β-Cu₂O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis

et al. 2021

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The physicochemical approaches and biological principles in bio-nanotechnology favor specially functionalized nanosized particles. Cuprous oxide nanoparticles (β-Cu2O NPs) of cuprite phase with a little tenorite (CuO) may be very effective in the development of novel therapeutic approaches against several fatalities including A-549 lung carcinoma cell lines. Consequently, the synthesis of β-Cu2O NPs for the improvement in the therapeutic index and drug delivery application is becoming an effective strategy in conventional anticarcinoma treatment. Hence, surface-enhanced nanosized spherical cuprous oxide nanoparticles (β-Cu2O NPs) of cuprite phase were successfully prepared using poly(ethylene glycol) (PEG) as an amphiphilic nonionic surfactant and l-ascorbic acid (K3[Cu(Cl5)]@LAA-PEG) reduced to cuprites β-Cu2O NPs via the sonochemical route. Less improved toxicity and better solubility of β-Cu2O NPs compared with Axitinib were a major reason for producing β-Cu2O NPs from K3[Cu(Cl5)]@LAA-PEG (LAA, l-ascorbic acid, PEG, poly(ethylene glycol) (PEG)). These nanoparticle syntheses have been suggested to influence their cytotoxicity, free-radical scavenging analysis, and reactive oxygen species (ROS) using poly(ethylene glycol) (PEG) and l-ascorbic acid (LAA) as coated and grafted materials due to their dose-dependent nature and IC50 calculations. The surface morphology of the formed β-Cu2O NPs has been examined via UV–vis spectroscopy, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy with energy diffraction scattering spectroscopy (SEM@EDS), field emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM) analysis. X-ray diffraction (XRD) and Brunauer–Emmett–Teller (BET) surface analysis results confirm the presence of pure cuprite with a very little amount of tenorite (CuO) phase, Dynamic light scattering (DLS) confirms the negative ζ-value with stable nature. Docking was performed using PDB of lung carcinomas and others, as rigid receptors, whereas the β-Cu2O NP cluster was treated as a flexible ligand.

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Efficient anticarcinogenic activity of α-Fe2O3 nanoparticles: In-vitro and computational study on human renal carcinoma cells HEK-293

Cited by 9 publications

References 62 publications

In Situ Biosynthesis of Reduced Alpha Hematite (α-Fe2O3) Nanoparticles by Stevia Rebaudiana L. Leaf Extract: Insights into Antioxidant, Antimicrobial, and Anticancer Properties

In Situ Biosynthesis of Reduced Alpha Hematite (α-Fe2O3) Nanoparticles by Stevia Rebaudiana L. Leaf Extract: Insights into Antioxidant, Antimicrobial, and Anticancer Properties

Fabrication of α-Fe₂O₃ Nanostructures: Synthesis, Characterization, and Their Promising Application in the Treatment of Carcinoma A549 Lung Cancer Cells

One-Pot Surface Modification of β-Cu₂O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis

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Efficient anticarcinogenic activity of α-Fe2O3 nanoparticles: In-vitro and computational study on human renal carcinoma cells HEK-293

Cited by 9 publications

References 62 publications

In Situ Biosynthesis of Reduced Alpha Hematite (α-Fe2O3) Nanoparticles by Stevia Rebaudiana L. Leaf Extract: Insights into Antioxidant, Antimicrobial, and Anticancer Properties

In Situ Biosynthesis of Reduced Alpha Hematite (α-Fe2O3) Nanoparticles by Stevia Rebaudiana L. Leaf Extract: Insights into Antioxidant, Antimicrobial, and Anticancer Properties

Fabrication of α-Fe2O3 Nanostructures: Synthesis, Characterization, and Their Promising Application in the Treatment of Carcinoma A549 Lung Cancer Cells

One-Pot Surface Modification of β-Cu2O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis

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Product

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Fabrication of α-Fe₂O₃ Nanostructures: Synthesis, Characterization, and Their Promising Application in the Treatment of Carcinoma A549 Lung Cancer Cells

One-Pot Surface Modification of β-Cu₂O NPs for Biocatalytic Performance against A-549 Lung Carcinoma Cell Lines through Docking Analysis