Efficient approach to in-situ preparation of anisotropic and assemblable gold nanoparticles mediated by stimuli-responsive PDMAEMA

Alinejad, Zeinab; Khakzad, Fahimeh; Mahdavian, Ali Reza

doi:10.1016/j.eurpolymj.2018.05.006

Cited by 19 publications

(23 citation statements)

References 47 publications

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“…A primary role of PDMAEMA in the synthesis of MNPs is the coating and protection of an inorganic metal core from the water environment. 22,23 Depending on environment pH, the polymeric coating thickness and density might be varied significantly. 33 The structure of the PDMAEMA n coating around the AgNP was analyzed with the RDFs calculated from the center of mass of the inorganic AgNP core (RDF−COM).…”

Section: Resultsmentioning

confidence: 99%

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pH-Responsive Coating of Silver Nanoparticles with Poly(2-(N,N-dimethylamino)ethyl methacrylate): The Role of Polymer Size and Degree of Protonation

2021

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Metrics & MoreArticle Recommendations * sı Supporting Information ABSTRACT: "Smart" nanomaterials composed of inorganic nanoparticles (NPs) and synthetic polymers represent an exciting and rapidly growing interdisciplinary area of materials science and engineering. Specifically, the coating of NPs with "smart" polymers capable of responding to applied external stimuli makes them promising for various biomedical applications, including drug delivery, tissue engineering, and medical diagnostics. In this work, we present an atomistic molecular dynamics (MD) simulation study of a silver NP (AgNP) grafted with a single-chain poly(2-(N,Ndimethylamino)ethyl methacrylate) (PDMAEMA). PDMAEMA possesses ionizable side-chain groups −N(CH 3 ) 2 , which can be converted into charged moieties upon solution acidification so that this makes the whole macromolecule to be pH responsive.We examined the pH-responsive adsorption of PDMAEMA onto the AgNP as a function of the polymer chain length (220−660 units) and the degree of protonation α.We found out that, in the neutral state at α = 0, the PDMAEMA chain was collapsed and adsorbed onto the AgNP due to the weak non-covalent interactions through the neutral dimethylamino moieties. Partial protonation of these side groups at α = 0.3−0.7 triggers ionic interactions, which drive the unfolding of the polymer chain toward an aqueous solution due to the electrostatic Coulombic repulsion between the generated charges. In the charged state at α = 1, the complete ionization of PDMAEMA side groups increases its solubility that leads to the substantial decrease in the polymer−NP interactions, followed by desorption of the polymer from the inorganic core. Thus, the gradual changes in the protonation degree of PDMAEMA fine-tune a balance of hydrophilic versus hydrophobic NP−polymer interactions and govern the shape, size, and water-protecting efficiency of the polymeric shell. Finally, our MD simulations demonstrated that such pH-adaptive behavior of PDMAEMA makes it promising for the development of a wide range of new generations of "intelligent" polymer coatings for metal NPs.

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Section: Resultsmentioning

confidence: 99%

“…This pH-responsive behavior of PDMAEMA agrees with experimental observations. 7,17,22,30,36 2.3. Model of the PDMAEMA−AgNP.…”

Section: Simulation Setupmentioning

confidence: 99%

pH-Responsive Coating of Silver Nanoparticles with Poly(2-(N,N-dimethylamino)ethyl methacrylate): The Role of Polymer Size and Degree of Protonation

2021

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“…As expected, the Au 3+ maximum absorption wavelength (λ max ) in HAuCl 4 was at 221 nm and MNPs showed no absorption in the 200–800 nm region. Appearance of the absorption at 539 nm refers to SPR of the prepared AuNPs in MNPs@Au with a spherical morphology and confirms their deposition onto MMNPs. − It should be noted that the high absorption intensity in the case of MNPs@Au can be attributed to the high concentration of MNP@Au dispersion. The SPR band of AuNPs at 539 nm was not clearly observable at low concentration, and UV–vis analysis of the composite nanoparticles was done at higher concentration than MNPs alone in order to confirm the deposition of Au NPs on the MMNP surface.…”

Section: Results and Discussionmentioning

confidence: 73%

Controlled Release and Photothermal Behavior of Multipurpose Nanocomposite Particles Containing Encapsulated Gold-Decorated Magnetite and 5-FU in Poly(lactide-co-glycolide)

Rad

Alinejad

Khoei

et al. 2019

ACS Biomater. Sci. Eng.

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Nowadays, many research studies have been conducted to prepare multidisciplinary probes in drug delivery systems and cancer therapy with high performance and minimum side effects. Here, poly(lactide-co-glycolide) (PLGA) nanocomposite particles containing 5-fluorouracil (5-FU) and gold-decorated magnetite nanoparticles with a raspberry-like morphology were designed and prepared as a novel and anticancer probe. For this reason, Fe 3 O 4 nanoparticles were synthesized by a coprecipitation method and modified with (3-mercaptopropyl) trimethoxysilane for the deposition of gold nanoparticles. Then, they were embedded in the PLGA matrix alone and accompanied by 5-FU with 92 and 88% loading efficiencies, respectively, through a multiple emulsion solvent evaporation method. Chemical structure and composition of the prepared samples in each step were completely characterized by several techniques. The morphology of the nanocomposite particles was assessed by field emission scanning electron microscopy, high-resolution transmission electron microscopy, and selected area electron diffraction patterns, and their particle size and colloidal stability after 1 week were evaluated by dynamic light scattering. Because of the coexistence of gold and Fe 3 O 4 nanoparticles, the final probe provided enhanced dual magneto and photothermal responses by increasing the temperature up to 42.7 °C under 5 min external alternating magnetic field and to 42.1 °C within just 1 min near-infrared irradiation at 808 nm. Trypan blue dye exclusion assays showed that they are biocompatible with reasonable toxicity (IC50 of 0.62 mg/mL) with respect to DU145 prostate cancer cells. Drug release profile of the 5-FU-loaded nanocomposite particles demonstrated their controlled release at 37 °C in phosphate-buffered saline solution. These indicate multidisciplinary characteristics of such particles in cancer therapy by photothermal, magnetic hyperthermia, and chemotherapy according to the presence of various active components.

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“…The adsorption of AuCl 4 − , which rapidly occurred in the first 15 min, over the hydrogel film was monitored using a UV–vis spectrophotometer [Figure (c)]. Some polymers are known to have a reducing effect other than the stabilizing effect, and such polymers are reported to cause an uncontrolled metal reduction that leads to the irregular nanoparticles with wide particle‐size distribution . Therefore, to avoid uncontrolled reduction, films were kept in the metal precursor salt solution for 15 min and immediately passed to the reduction step.…”

Section: Resultsmentioning

confidence: 99%

Preparation and catalytic properties of modified PGMA‐based pH‐responsive hydrogel films as a novel template for in situ synthesis of Au, Ag, and Au:Ag nanoparticles

Koçak

2019

J of Applied Polymer Sci

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Metal‐nanoparticle (M‐NP)‐modified glycidyl methacrylate (GMA)‐based hydrogel film composites were synthesized and assessed for their catalytic activities by reducing para‐nitrophenol (p‐NP) to para‐aminophenol (p‐AP) with sodium borohydride. Poly(ethylene glycol)methyl ether‐block‐poly(glycidyl methacrylate)‐block‐poly(methyl methacrylate) (MPEG‐b‐PGMA‐b‐PMMA) triblock copolymer was synthesized via atom transfer‐radical polymerization. The epoxy ring of the PGMA blocks was opened by the addition of 1‐methylpiperazine. The resulting bifunctional polymer containing 2‐hydroxy‐3‐methyl piperazinepropyl methacrylate units was used to synthesize novel crosslinked hydrogel films by quaternization of the tertiary amine (methylpiperazine) with 1,2‐bis(2‐iodoethoxy)ethane. The synthesized hydrogel film swelled in aqueous solution when the pH was changed from basic to acidic. The prepared MPEG‐b‐PHMPPMA‐b‐PMMA hydrogel film was used as an immobilizing matrix to form monometallic silver (Ag) and gold (Au) and bimetallic alloy gold:silver (Au:Ag) nanoparticles. The M‐NP/hydrogel film composites were characterized by transmission electron microscopy, scanning electron microscopy, thermogravimetric analysis, and ultraviolet–visible spectrophotometry. The synthesized M‐NP/hydrogel film composites showed good catalytic activity to reduce p‐NP to p‐AP. The composites were also found to be reusable as their activity only slightly dropped after 10 consecutive uses. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48360.

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Efficient approach to in-situ preparation of anisotropic and assemblable gold nanoparticles mediated by stimuli-responsive PDMAEMA

Cited by 19 publications

References 47 publications

pH-Responsive Coating of Silver Nanoparticles with Poly(2-(N,N-dimethylamino)ethyl methacrylate): The Role of Polymer Size and Degree of Protonation

pH-Responsive Coating of Silver Nanoparticles with Poly(2-(N,N-dimethylamino)ethyl methacrylate): The Role of Polymer Size and Degree of Protonation

Controlled Release and Photothermal Behavior of Multipurpose Nanocomposite Particles Containing Encapsulated Gold-Decorated Magnetite and 5-FU in Poly(lactide-co-glycolide)

Preparation and catalytic properties of modified PGMA‐based pH‐responsive hydrogel films as a novel template for in situ synthesis of Au, Ag, and Au:Ag nanoparticles

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