Efficient biodegradation of chlortetracycline in high concentration from strong-acidity pharmaceutical residue with degrading fungi

Li, Yanju; Chen, Haibo; Wang, Yuzhou; Yang, Zhen; Zhang, Huiyan

doi:10.1016/j.jhazmat.2021.127671

Cited by 9 publications

(3 citation statements)

References 30 publications

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“…janthinellum and P. oxalicum have also demonstrated good capabilities in degrading CTC Paecilomyces sp.…”

Section: Microbial Degradation Of Tcsmentioning

confidence: 99%

“…Some of these strains may carry the wabG pathogenicity gene, which pose a risk of horizontal transfer of antibiotic resistance genes . Additionally, the process of reducing the biotoxicity of degradation products involves the transformation of TCs from complex structures into simpler, smaller molecules . Importantly, the assessment of the degradation product toxicity is based on a mixture of various components.…”

Section: Toxicity Of Microbial Degradation Products Of Tcsmentioning

confidence: 99%

See 1 more Smart Citation

Microbial Degradation of Tetracycline Antibiotics: Mechanisms and Environmental Implications

Li,

Zheng,

Guo

et al. 2024

J. Agric. Food Chem.

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The escalating global consumption of tetracyclines (TCs) as broad-spectrum antibiotics necessitates innovative approaches to mitigate their pervasive environmental persistence and associated risks. While initiatives such as China's antimicrobial reduction efforts highlight the urgency of responsible TC usage, the need for efficient degradation methods remains paramount. Microbial degradation emerges as a promising solution, offering novel insights into degradation pathways and mechanisms. Despite challenges, including the optimization of microbial activity conditions and the risk of antibiotic resistance development, microbial degradation showcases significant innovation in its cost-effectiveness, environmental friendliness, and simplicity of implementation compared to traditional degradation methods. While the published reviews have summarized some aspects of biodegradation of TCs, a systematic and comprehensive summary of all the TC biodegradation pathways, reactions, intermediates, and final products including ring-opening products involved with enzymes and mechanisms of each bacterium and fungus reported is necessary. This review aims to fill the current gap in the literature by offering a thorough and systematic overview of the structure, bioactivity mechanism, detection methods, microbial degradation pathways, and molecular mechanisms of all tetracycline antibiotics in various microorganisms. It comprehensively collects and analyzes data on the microbial degradation pathways, including bacteria and fungi, intermediate and final products, ring-opening products, product toxicity, and the degradation mechanisms for all tetracyclines. Additionally, it points out future directions for the discovery of degradation-related genes/enzymes and microbial resources that can effectively degrade tetracyclines. This review is expected to contribute to advancing knowledge in this field and promoting the development of sustainable remediation strategies for contaminated environments.

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“…janthinellum and P. oxalicum have also demonstrated good capabilities in degrading CTC Paecilomyces sp.…”

Section: Microbial Degradation Of Tcsmentioning

confidence: 99%

Section: Toxicity Of Microbial Degradation Products Of Tcsmentioning

confidence: 99%

Microbial Degradation of Tetracycline Antibiotics: Mechanisms and Environmental Implications

Li,

Zheng,

Guo

et al. 2024

J. Agric. Food Chem.

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show abstract

“…Desde a descoberta da penicilina, os antibióticos têm sido muito utilizados não apenas para proteger a saúde humana, mas também para promover o crescimento de animais na pecuária como gados e aves (Yang et al, 2021;Cai et al, 2022). Atualmente a China é considerada o maior produtor de antibióticos no mundo, representando cerca de 70% da quantidade mundial total, com rendimento anual de dois milhões de toneladas (Li et al, 2021). O descarte sem o tratamento adequado de antibiótico pode levar ao desenvolvimento de bactérias resistentes, causando problemas para a saúde pública devido a elevada ocorrência de infecções clínicas (Holanda et al, 2019).…”

Section: Biorremediação De Antibióticosunclassified

Biodegradação e biorremediação de fármacos, cosméticos e produtos de higiene pessoal

Silva,

Melo,

Uber

et al. 2022

Biodegradação E Biorremediação

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Efficient degradation of chlortetracycline in water by ultrasound activation of flexible ZnCoO doped PVDF membranes with high β phase

Meng

Wang

Huo

et al. 2023

Applied Surface Science

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Efficient biodegradation of chlortetracycline in high concentration from strong-acidity pharmaceutical residue with degrading fungi

Cited by 9 publications

References 30 publications

Microbial Degradation of Tetracycline Antibiotics: Mechanisms and Environmental Implications

Microbial Degradation of Tetracycline Antibiotics: Mechanisms and Environmental Implications

Biodegradação e biorremediação de fármacos, cosméticos e produtos de higiene pessoal

Efficient degradation of chlortetracycline in water by ultrasound activation of flexible ZnCoO doped PVDF membranes with high β phase

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