Efficient Ca<sup>2+</sup> buffering in fast‐spiking basket cells of rat hippocampus

Aponte, Yeka; Bischofberger, Josef; Jónás, Péter

doi:10.1113/jphysiol.2007.147298

Cited by 83 publications

(96 citation statements)

References 54 publications

(93 reference statements)

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“…Thus, Ca 2ϩ transients mediated by VDCCs, CP-AMPA, and mGluRI receptors may act synergistically to induce LTP at MF-PII synapses (Topolnik et al, 2005(Topolnik et al, , 2009. Conversely, the apparent absence of synaptic plasticity at PP inputs in our experiments could be explained by the absence of CP-AMPARs, the negligible NMDAR-mediated component (present results) and the small voltage-dependent Ca 2ϩ transients in distal dendrites of PIIs (Aponte et al, 2008).…”

Section: Molecular Mechanisms Of Synapse-specific Plasticitycontrasting

confidence: 48%

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Associative Plasticity at Excitatory Synapses Facilitates Recruitment of Fast-Spiking Interneurons in the Dentate Gyrus

Sambandan¹,

Sauer²,

Vida³

et al. 2010

J. Neurosci.

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Fast-spiking perisomatic-inhibitory interneurons (PIIs-permeable AMPARs and do not show plasticity on associative activation. Thus, precise recruitment of PIIs requires excitation through MF-PII synapses during feedforward activation. We propose that associative plasticity at these synapses is a central mechanism that adjusts inhibition levels to maintain sparse activity and to improve signal-to-noise ratio in the DG network.

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Section: Molecular Mechanisms Of Synapse-specific Plasticitycontrasting

confidence: 48%

“…Basket cells express voltagedependent Ca 2ϩ channels (VDCCs) on their soma and proximal dendrites (Aponte et al, 2008;Bucurenciu et al, 2008). Ca 2ϩ entry through these channels during action potentials could support LTP induction at proximal MF inputs (Galván et al, 2008;Topolnik et al, 2009).…”

Section: Molecular Mechanisms Of Synapse-specific Plasticitymentioning

confidence: 99%

Associative Plasticity at Excitatory Synapses Facilitates Recruitment of Fast-Spiking Interneurons in the Dentate Gyrus

Sambandan¹,

Sauer²,

Vida³

et al. 2010

J. Neurosci.

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“…For CA1 pyramidal neuron recording, cells of large somata in the stratum pyramidale with accommodating firing patterns were chosen. Dentate gyrus (DG) BCs were selected in accordance with previous reports (Koh et al, 1995;Martina et al, 1998;Aponte et al, 2008): (1) a relatively large size of cell body near the border between granule cell layer and hilus; (2) high-frequency (Ն70 Hz) action potential (AP) phenotype; (3) relatively low input resistance (Ͻ170 M⍀); (4) little sag response upon membrane hyperpolarization. The recording temperature was 22Ϫ24°C.…”

Section: Methodsmentioning

confidence: 99%

“…1 A). Neurons in the CA1 area and the DG were selected as previously described (Martina et al, 1998;Lien and Jonas, 2003;Aponte et al, 2008;Liao and Lien, 2009). Under current-clamp configuration at 23 Ϯ 1°C, CA1 PNs generated regular and accommodating AP trains upon injection of 1 s depolarizing current (ϩ600 pA) pulses and exhibited sag responses in response to 1 s hyperpolarizing current (Ϫ300 pA) pulses with apparent input resistance of 176 Ϯ 9.1 M⍀ (n ϭ 30, Fig.…”

Section: Functional Asics Are Differentially Expressed In Hippocampalmentioning

confidence: 99%

“…Soma-targeting inhibitory interneurons, such as fast-spiking basket cells (BCs), control the spike initiation of principal neurons via axonal innervations onto perisomatic areas of principal neurons (Cobb et al, 1995;Miles et al, 1996;Kraushaar and Jonas, 2000), whereas dendrite-targeting inhibitory interneurons, such as oriens lacunosum-moleculare (O-LM) cells, regulate dendritic Na ϩ or Ca 2ϩ spikes and synaptic plasticity by innervating dendritic domains of principal neurons (Miles et al, 1996). These two distinct GABAergic interneuron subtypes differ not only in their intrinsic properties, such as neurochemical contents, Ca 2ϩ -buffering proteins/homeostasis, ion channels, and transmitter receptors (Koh et al, 1995;Freund and Buzsáki, 1996;Martina et al, 1998;Lien et al, 2002;Pouille and Scanziani, 2004;Aponte et al, 2008;Liao and Lien, 2009), but also in their synaptic and network functions (Klausberger et al, 2003;Pouille and Scanziani, 2004;Klausberger and Somogyi, 2008). Unfortunately, the lack of measurement of ASIC currents from identified GABAergic inhibitory interneurons has left a fundamental question unresolved: is the ASIC expression among hippocampal GABAergic inhibitory interneurons cell type-specific?…”

Section: Introductionmentioning

confidence: 99%

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Cell Type-Specific Expression of Acid-Sensing Ion Channels in Hippocampal Interneurons

Weng¹,

Lin²,

Lien³

2010

J. Neurosci.

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Acid-sensing ion channels (ASICs), a member of the degenerin/epithelial Na ϩ channel superfamily, are widely expressed in the mammalian CNS. Accumulating evidence suggests that ASIC current density is higher in GABAergic interneurons than that in glutamatergic pyramidal neurons (PNs) in the hippocampus. Such differential expression of ASICs in cortical networks is thought to be a key element for seizure termination.

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“Fast” plasma membrane calcium pump PMCA2a concentrates in GABAergic terminals in the adult rat brain

Burette

Strehler

Weinberg

2008

J of Comparative Neurology

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The plasma membrane Ca 2+ -ATPases (PMCA) represent the major high-affinity Ca 2+ extrusion system in the brain. PMCAs comprise four isoforms and over 20 splice variants. Their different functional properties may permit different PMCA splice variants to accommodate different kinds of local [Ca 2+ ] transients, but for a specific PMCA to play a unique role in local Ca 2+ handling it must be targeted to the appropriate subcellular compartment. We used immunohistochemistry to study the spatial distribution of PMCA2a-one of the two major carboxyl-terminal splice variants of PMCA2-in the adult rat brain, testing whether this isoform, with especially high basal activity, is targeted to specific subcellular compartments. In striking contrast to the widespread distribution of PMCA2 as a whole, we found that PMCA2a is largely restricted to parvalbumin-positive inhibitory presynaptic terminals throughout the brain. The only major exception to this targeting pattern was in the cerebellar cortex, where PMCA2a also concentrates postsynaptically, in the spines of Purkinje cells. We propose that the fast Ca 2+ activation kinetics and high V max of PMCA2a make this pump especially suited for rapid clearance of presynaptic Ca 2+ in fast-spiking inhibitory nerve terminals, which face severe transient calcium loads. Keywords calcium extrusion; calcium pump; immunohistochemistry; parvalbumin; presynaptic terminals; fastspiking basket cells Ca 2+ signaling plays a central role in neurons. To regulate different functions independently within spatially restricted zones, neurons compartmentalize their Ca 2+ signals within microdomains. Thus, within a single neuron characteristic ensembles of Ca 2+ channels, transporters, and binding proteins are found at distinct locations within the soma, axon, and dendrites (Bootman et al., 2001;Rizzuto, 2001). Growing evidence shows that the plasma membrane Ca 2+ -ATPase (PMCA) family of calcium pumps plays an important role in shaping Ca 2+ dynamics in these restricted cellular compartments (Strehler et al., 2007a).An intriguing feature of the PMCA family is its diversity. In mammals, four PMCA isoforms are encoded by separate genes. From these four genes, more than 20 distinct PMCAs are generated through alternative splicing (Strehler and Zacharias, 2001;Di Leva et al., 2008 Alternative splicing affects two major regions of the protein: the first intracellular loop (site A), and the C-terminal tail (site C), which includes sites for phosphorylation by protein kinases A and C. Calmodulin binding to the C-tail regulates the activity of the pump. In its absence, the C-tail acts as an autoinhibitory domain of the pump (Penniston et al., 1988). When calmodulin binds, the C-tail dissociates from the catalytic core, thus activating the pump.The main splice variants generated at the C-terminal site (termed "a" and "b") differ in their primary amino acid sequence due to a change in reading frame. Functionally, the most notable consequence of C-terminal splicing is a difference in calmodulin and ki...

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Efficient Ca²⁺ buffering in fast‐spiking basket cells of rat hippocampus

Abstract: Fast

Cited by 83 publications

References 54 publications

Associative Plasticity at Excitatory Synapses Facilitates Recruitment of Fast-Spiking Interneurons in the Dentate Gyrus

Associative Plasticity at Excitatory Synapses Facilitates Recruitment of Fast-Spiking Interneurons in the Dentate Gyrus

Cell Type-Specific Expression of Acid-Sensing Ion Channels in Hippocampal Interneurons

“Fast” plasma membrane calcium pump PMCA2a concentrates in GABAergic terminals in the adult rat brain

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Efficient Ca2+ buffering in fast‐spiking basket cells of rat hippocampus

Abstract: Fast

Cited by 83 publications

References 54 publications

Associative Plasticity at Excitatory Synapses Facilitates Recruitment of Fast-Spiking Interneurons in the Dentate Gyrus

Associative Plasticity at Excitatory Synapses Facilitates Recruitment of Fast-Spiking Interneurons in the Dentate Gyrus

Cell Type-Specific Expression of Acid-Sensing Ion Channels in Hippocampal Interneurons

“Fast” plasma membrane calcium pump PMCA2a concentrates in GABAergic terminals in the adult rat brain

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Efficient Ca²⁺ buffering in fast‐spiking basket cells of rat hippocampus