Efficient catalyst-free direct amidation of non-activated carboxylic acids from carbodiimides

Abstract

A novel and efficient catalyst and activating agent free amidation method via direct amidation of carboxylic acids where carbodiimides act as a reagent instead of an activating agent was reported....

Visible-light-induced Fe(iii)-promoted reduction amidation of 1,4,2-dioxazol-5-one

“…Among the numerous synthetic avenues to amide, the most traditional and well-established approach revolves around the reaction of amine compounds, acting as nucleophiles, with carboxylic acids [5][6][7][8] or their derivatives. [9][10][11][12] Historically, the preparation of amides has encompassed a broad range of methods, including the employment of carbon diimide condensation reagents, [13][14][15] onium salt condensation reagents, [16][17][18] and organophosphorus condensation reagents. [19][20][21] In recent years, the synthesis of amides by constructing nitrogen radical intermediates has been particularly prosperous.…”