The development of efficienth eterogeneous catalysts suitable for carbon capture and utilization(CCU) under mild conditions is ap romisingstep towards mitigating the growingc oncentration of CO 2 in the atmosphere.H erein, we report the constructiono fahydrogen-bonded 3D framework, {[Zn(hfipbba)(MA)]•3 DMF} n (hfipbba = 4,4'-(hexaflouroisopropylene)bis(benzoic acid)) (HbMOF1)u tilizingZ n II center,apartially fluorinated, long-chain dicarboxylate ligand (hfipbba), anda na mine-rich melamine (MA) coligand.I nterestingly,t he framework possesses two types of 1D channels decorated with CO 2-philic (ÀNH 2 and ÀCF 3) groups that promote the highly selectiveC O 2 adsorption by the framework,w hich was supported by computational simulations. Further,t he synergistic involvement of both Lewis acidic and basic sites exposedi nt he confined 1D channels along with high thermala nd chemical stabilityr endered HbMOF1 ag ood heterogeneousc atalyst for the highly efficient fixation of CO 2 in ar eaction with terminal/internal epoxidesa tm ild conditions (RT and 1bar CO 2). Moreover,i ndepth theoretical studies were carried out using periodic DFT to obtaint he relative energies for each stage involved in the catalytic reaction anda ni nsight mechanisticd etails of the reactioni sp resented. Overall,t his work represents ar are demonstrationo fr ational design of ap orousZ n II MOF incorporatingm ultiple functional sites suitable for highly efficient fixationo fCO 2 with terminal/internal epoxides at mild conditions supported by comprehensive theoretical studies.