Efficient Electrogenerated Chemiluminescence from Cyclometalated Iridium(III) Complexes

Abstract

Very efficient electrogenerated chemiluminescence (ECL) phenomena were realized by deliberately tuning electron-transfer reactions from electrochemically generated electron donor to metal complex radical cations. By controlling the relative positions of HOMO and LUMO levels (oxidation potential and reduction potential) of Ir(III) complexes, we could obtain 77 times higher ECL from iridium(III) complexes in the presence of TPA than that of the Ru(bpy)32+/TPA system. This high ECL efficiency of new Ir(III) complexes can be used in many interesting applications such as sensors and luminescent devices.

The crystal structure of 6-chloro-2,4-diphenylquinoline

“…antimalarial, antibacterial, anticancer and antioxidant, have been attributed to these structures and has found application in the pharmaceutical industry [1][2][3][4][5][6]. Their unique spectral and photochemical properties have also found application in a variety of elds such as photolytic cleavage of DNA, electrogenerated chemiluminescence and light emitting diodes [7][8][9][10][11].…”

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

“…Quinolines and their derivatives are important heterocyclic compounds because of their wide-ranging biological activities [52][53][54] and interesting photochemical properties [55]. For example, chloroquine (46) has been used for its antimalarial activity for more than 60 years; [56][57][58] bedaquiline (47), an inhibitor of the mycobacterial ATP synthase, has been approved to treat multi-drug resistant tuberculosis, [59] and cabozantinib (48), a multitargeted receptor tyrosine kinase inhibitor, showed effective anticancer activity and has been marketed for the treatment of medullary thyroid cancer ( Figure 4) Quinolines and their derivatives are important heterocyclic compounds because of their wide-ranging biological activities [52][53][54] and interesting photochemical properties [55].…”

“…For example, chloroquine (46) has been used for its antimalarial activity for more than 60 years; [56][57][58] bedaquiline (47), an inhibitor of the mycobacterial ATP synthase, has been approved to treat multi-drug resistant tuberculosis, [59] and cabozantinib (48), a multitargeted receptor tyrosine kinase inhibitor, showed effective anticancer activity and has been marketed for the treatment of medullary thyroid cancer ( Figure 4) Quinolines and their derivatives are important heterocyclic compounds because of their wide-ranging biological activities [52][53][54] and interesting photochemical properties [55]. For example, chloroquine (46) has been used for its antimalarial activity for more than 60 years; [56][57][58] bedaquiline (47), an inhibitor of the mycobacterial ATP synthase, has been approved to treat multi-drug resistant tuberculosis, [59] and cabozantinib (48), a multitargeted receptor tyrosine kinase inhibitor, showed effective anticancer activity and has been marketed for the treatment of medullary thyroid cancer ( Figure 4) [60].…”

“…Another green-chemistry related approach was recently reported by Kumar et al [62] for the synthesis of novel quinolin-4-ylmethoxy-chromen-2/-4-ones 56, 58 under MW conditions. The protocol involves a one-pot reaction of aromatic amines 53 and aldehydes 54, and a propargylated-flavone (55) or -coumarin (57) using YbCl3 (2 mol%) as catalyst. The reactions were carried out at 100 °C, and led to the expected products with excellent yields after a short reaction time (4 min).…”

Imaging Analysis Based on Electrogenerated Chemiluminescence

“…In comparison with the classical Ru(bpy) 3 2? , cyclometalated iridium(III) complexes generally possess much higher photoluminescence (PL) efficiency and easy tunability of the emission color. By modulating the ligand and changing the coordination mode, a series of cyclometalated iridium(III) complexes have been designed, synthesized, and thoroughly investigated through photophysics, electrochemistry, and ECL [23][24][25][26][27]. The development of new ECL emitters with different emission colors makes it possible to simultaneously determine multiplex analytes in clinical diagnostics.…”