Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water‐Dispersible Fluorous Supraparticles

Abstract

Fluorophobic-driven assemblies of gold nanomaterials were stabilized into water-dispersible fluorous supraparticles by the film-forming protein hydrophobin II. The strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space.T he inner fluorous compartments allowefficient encapsulation and transport of high loadings of partially fluorinated drug molecules in water.

Luminescent gold nanoclusters for bioimaging applications

“…Nevertheless, hydrogen bonding has been utilized to achieve two-dimensional (2D) and three-dimensional (3D) nanocluster superstructures [95,96]. The NC assemblies have been used to encapsu- late poorly water-soluble fluorinated drugs through nanoconfinement [97]. Chandra et al recently reported highly luminescent gold nanocluster frameworks (AuNCFs) using selfassembly through metal chelation [53].…”

Fluorinated PLGA Nanoparticles for Enhanced Drug Encapsulation and 19F NMR Detection

“…[24] Ac ombinationo ft wo different effects seems to govern the drug encapsulation process:F irst, considering the common attitude of PLGA to entrap highly hydrophobic molecules, it is reasonable that both F 9 -PLGA and PLGA NPs encapsulated a higher amount of more hydrophobic LEF.H igher encapsulation yields observed for F 9 -PLGA NPs with respect to unmodified PLGA NPs might be explained by an increased fluorophilicity of the confined environment( i.e.,p ossible F•••F interactions among the fluorinated groups of the polymer and the drugs). [25] The hypothesis of possible F•••F interactions was investigated throughs olid-state NMR on lyophilized LEF@F 9 -PLGA NP formulations. In Figures S7 and S8 the 1 H-13 Ca nd 19 F-13 CC PMAS NMR spectra of LEF@F 9 -PLGA, F 9 -PLGA and pure LEF are reported.…”

Seeing the Supracolloidal Assemblies in 3D: Unraveling High-Resolution Structures Using Electron Tomography

“…48−56 Pigliacelli et al reported the self-assembled fluorous supraparticles (FSPs) to efficiently encapsulate poorly water-soluble fluorinated drugs (Figure 5a). 90 The FSPs were fabricated using AuNPs capped with 1H,1H,2H,2H-perfluorodecanethiol (PFDT) ligands in the presence of the film-forming protein hydrophobin-II (HFB-II). Two types of NPs, viz., spherical AuNCs with an average diameter of 1.6 ± 0.6 nm and plasmonic AuNPs with an average diameter of 3.8 ± 0.8 nm, were used to study the effect of size on compartmentalization.…”