2019
DOI: 10.1101/608430
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Efficient enzyme coupling algorithms identify functional pathways in genome-scale metabolic models

Abstract: Flux coupling identifies sets of reactions whose fluxes are "coupled" or correlated in genome-scale models. By identified sets of coupled reactions, modelers can 1.) reduce the dimensionality of genome-scale models, 2.) identify reactions that must be modulated together during metabolic engineering, and 3.) identify sets of important enzymes using high-throughput data. We present three computational tools to improve the efficiency, applicability, and biological interpretability of flux coupling analysis.The fi… Show more

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“…Two metabolic reactions are coupled if a nonzero flux through one reaction implies a nonzero flux through the other. Flux covariance follows from flux coupling (Heinonen et al , 2019 ; preprint: Pradhan et al , 2019 ; Thommes et al , 2019 ). Importantly for modeling evolutionary adaptation, flux coupling implies genetic dependences between the corresponding enzyme‐coding genes (Notebaart et al , 2008 ).…”
Section: Resultsmentioning
confidence: 99%
“…Two metabolic reactions are coupled if a nonzero flux through one reaction implies a nonzero flux through the other. Flux covariance follows from flux coupling (Heinonen et al , 2019 ; preprint: Pradhan et al , 2019 ; Thommes et al , 2019 ). Importantly for modeling evolutionary adaptation, flux coupling implies genetic dependences between the corresponding enzyme‐coding genes (Notebaart et al , 2008 ).…”
Section: Resultsmentioning
confidence: 99%