2021
DOI: 10.1016/j.msec.2021.112027
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Efficient, enzyme responsive and tumor receptor targeting gelatin nanoparticles decorated with concanavalin-A for site-specific and controlled drug delivery for cancer therapy

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Cited by 70 publications
(27 citation statements)
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“…Verma designed a smart inhalable nanocarrier by complexation of gelatin with cisplatin for lung tumor therapy. After the degradation of gelatin, cisplatin was exposed to physiological salts and exchanged with chloride ions, leading to the fast release of cisplatin at the tumor site [ 79 ].…”
Section: Enzyme-responsive Nanocarriersmentioning
confidence: 99%
“…Verma designed a smart inhalable nanocarrier by complexation of gelatin with cisplatin for lung tumor therapy. After the degradation of gelatin, cisplatin was exposed to physiological salts and exchanged with chloride ions, leading to the fast release of cisplatin at the tumor site [ 79 ].…”
Section: Enzyme-responsive Nanocarriersmentioning
confidence: 99%
“…Finally, while antibodies are most commonly associated with antigen targeting, ADCs are also being developed to conjugate cytotoxic drugs to tumor-specific receptor ligands. While these targeting modalities are not covered in this review, we point readers to these recently published reviews [191][192][193][194][195].…”
Section: Novel Target Antigensmentioning
confidence: 99%
“…Cell viability (%) = OD Sample /OD Control ×100% (5) where the OD Sample and OD Control were the optical density (OD) of samples and negative controls, respectively. The Student's t-test proceeded to verify the signi cance of any statistical differences, and all quantitative data were shown as the form of mean ± SD value.…”
Section: In Vitro Cytotoxicity Assaymentioning
confidence: 99%
“…Free PTX and PTX-encapsulated S1 ~ S4 nanomicelles were seeded in a 6-well plate containing 1×10 5 Colon-26 cells per well and cultured. After 24 h, the initial medium was removed, following the supplemention of new medium with 30 µg ml − 1 of PTX and incubation for 6 h. The cells were xed by 4% paraformaldehyde and rinsed using PBS thrice.…”
Section: Celluar Uptakementioning
confidence: 99%
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