2015
DOI: 10.1007/s11222-015-9610-5
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Efficient estimation of variance components in nonparametric mixed-effects models with large samples

Abstract: Linear mixed-effects (LME) regression models are a popular approach for analyzing correlated data. Nonparametric extensions of the LME regression model have been proposed, but the heavy computational cost makes these extensions impractical for analyzing large samples. In particular, simultaneous estimation of the variance components and smoothing parameters poses a computational challenge when working with large samples. To overcome this computational burden, we propose a two-stage estimation procedure for fit… Show more

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Cited by 11 publications
(10 citation statements)
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“…We fit the above model to the same three response variables (effective, genuine, and pleasant) using the same two-stage estimation procedure [29]. We used a cubic smoothing spline for the timing asymmetry effect function, and the three covariates were modeled as previously described, i.e., using a cubic smoothing spline for age and drinking, and a nominal smoothing spline for gender.…”
Section: Methodsmentioning
confidence: 99%
“…We fit the above model to the same three response variables (effective, genuine, and pleasant) using the same two-stage estimation procedure [29]. We used a cubic smoothing spline for the timing asymmetry effect function, and the three covariates were modeled as previously described, i.e., using a cubic smoothing spline for age and drinking, and a nominal smoothing spline for gender.…”
Section: Methodsmentioning
confidence: 99%
“…As alternatives to the monotonic model (abbreviated as MO), we considered simple linear (LIN) and categorical (CAT) regression, isotonic regression (ISO; Barlow et al , 1972; Robertson et al , 1988), penalized ordinal regression (OS; Gertheiss & Tutz, 2009; Gu, 2013), penalized ordinal regression with monotonicity constraint (OSMO; Helwig, 2017), as well as linear and cubic spline models (LS and CS; e.g., Gu, 2013; Helwig, 2016). The latter two are primarily designed for continuous responses but may still perform reasonably well for linear relationships or a sufficiently large number of predictor categories.…”
Section: Simulationsmentioning
confidence: 99%
“…We used the same simulation conditions as in Section 3.1 with one exception described in following. As underlying data generating processes, we considered the main effects and interaction models described in Section 3.1 in three different variations: 0 2 4 6 8 10 0 2 4 6 8 10 0 2 4 6 8 10 0 2 4 6 8 10 0 2 4 6 8 10 0 2 4 6 8 10 0 2 4 6 8 10 0 2 4 6 8 10 0 2 4 6 8 10 0 2 4 6 8 10 0 2 4 6 8 10 0 2 4 6 8 10 linear (LIN) and categorical (CAT) regression 3 , isotonic regression (ISO; Barlow et al, 1972;Robertson et al, 1988), penalized ordinal regression (OS; Gertheiss & Tutz, 2009;Gu, 2013), penalized ordinal regression with monotonicity constraint (OSMO; Helwig, 2017), as well as linear and cubic spline models (LS and CS; e.g., Gu, 2013;Helwig, 2016). The latter two are primarily designed for continuous responses but may still perform reasonably well for linear relationships or sufficiently large number of predictor categories.…”
Section: Comparison To Other Approachesmentioning
confidence: 99%