Efficient Heated Ultrasound Assisted Extraction and Clean-Up Method for Quantifying Paclitaxel Concentrations in Taxus Wallichiana

Ghaffar, Nasreen; Lee, Linda; Choi, Youn Jeong; Perre, Chloé de; Khan, Bushra

doi:10.1080/03067319.2019.1669584

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…Yews have also several applications in making of local beverages using their leaves extract, high-priced furniture, oil extraction, timber, fuel, traditional tea, and for woodcarving [ 34 , 36 ]. However, they gained global notoriety for their FDA (US) approved anticancer/cardiovascular drug paclitaxel (taxol) ( Figure 3 ) which was recognized as one of the most effective and powerful antitumor agents [ 40 ]. Nowadays, as an option, this drug is largely produced from its precursors like 10-deacetyl baccatin III (10 DAB III), cephalomannine and baccatin III which are also more readily available in different parts of plants of the genus Taxus (see Table 1 and Figure 3 ) [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical compositions and biological activities of the oils from the genus Taxus and factors limiting the regeneration of endangered yews: a review

DHAKAL¹,

KHOSLA²,

GETAHUN³

2022

Turkish Journal of Chemistry

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The genus Taxus (yews) is the largest genus of the family Taxaceae. It comprises about 24 species with 55 varieties distributed mainly in Asia, Europe, North Africa, and North America. In addition to the taxane diterpenoids and the cancer drug taxol, its species contain many essential oils with actual or potential biological activity. This review covers the chemical constituents as well as biological activities of these oils that have been studied in fourteen countries over 46 years (1975–2021). It also discusses the biotic and abiotic factors that limit the regeneration of these economically and medicinally important plants.

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Section: Introductionmentioning

confidence: 99%

Chemical compositions and biological activities of the oils from the genus Taxus and factors limiting the regeneration of endangered yews: a review

DHAKAL¹,

KHOSLA²,

GETAHUN³

2022

Turkish Journal of Chemistry

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Plant Alkaloids: Production, Extraction, and Potential Therapeutic Properties

Pereira

Cassani

García-Oliveira

et al. 2023

Natural Secondary Metabolites

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Natural Taxanes: From Plant Composition to Human Pharmacology and Toxicity

Nižnanský

Osinová

Kuruc

et al. 2022

IJMS

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Biologically active taxanes, present in small- to medium-sized evergreen conifers of various Taxus species, are widely used for their antioxidant, antimicrobial and anti-inflammatory effects, but mostly for their antitumour effects used in the treatment of solid tumours of the breast, ovary, lung, bladder, prostate, oesophagus and melanoma. More of the substances found in Taxus plant extracts have medical potential. Therefore, at the beginning of this review, we describe the methods of isolation, identification and determination of taxanes in different plant parts. One of the most important taxanes is paclitaxel, for which we summarize the pharmacokinetic parameters of its different formulations. We also describe toxicological risks during clinical therapy such as hypersensitivity, neurotoxicity, gastrointestinal, cardiovascular, haematological, skin and renal toxicity and toxicity to the respiratory system. Since the effect of the drug-form PTX is enhanced by various Taxus spp. extracts, we summarize published clinical intoxications and all fatal poisonings for the Taxus baccata plant. This showed that, despite their significant use in anticancer treatment, attention should also be focused on the risk of fatal intoxication due to ingestion of extracts from these plants, which are commonly found in our surroundings.

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Efficient Heated Ultrasound Assisted Extraction and Clean-Up Method for Quantifying Paclitaxel Concentrations in Taxus Wallichiana

Cited by 3 publications

References 40 publications

Chemical compositions and biological activities of the oils from the genus Taxus and factors limiting the regeneration of endangered yews: a review

Chemical compositions and biological activities of the oils from the genus Taxus and factors limiting the regeneration of endangered yews: a review

Plant Alkaloids: Production, Extraction, and Potential Therapeutic Properties

Natural Taxanes: From Plant Composition to Human Pharmacology and Toxicity

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