Image interpolation, as a method of obtaining a high-resolution image from the corresponding low-resolution image, is a classical problem in image processing. In this paper, we propose a novel energy-driven interpolation algorithm employing Gaussian process regression. In our algorithm, each interpolated pixel is predicted by a combination of two information sources: first is a statistical model adopted to mine underlying information, and second is an energy computation technique used to acquire information on pixel properties. We further demonstrate that our algorithm can not only achieve image interpolation, but also reduce noise in the original image. Our experiments show that the proposed algorithm can achieve encouraging performance in terms of image visualization and quantitative measures.