Efficient induction of Semliki Forest virus and mumps virus neutralizing anti-anti-idiotypic antibodies using Quil A as adjuvant

Oosterlaken, T. A. M.; Brandenburg, A. H.; Schielen, Peter C. J. I.; Fransen, René; Kraaijeveld, C. A.; Snippe, H.

doi:10.1016/0022-1759(91)90003-x

Cited by 8 publications

(3 citation statements)

References 14 publications

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“…Some saponins have also been shown to exhibit direct virucidal mechanisms of action, including destruction of viral envelopes and interaction with host cell membranes, leading to the loss of viral binding sites [29–36]. …”

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Prevention of Rotavirus Infections In Vitro with Aqueous Extracts of Quillaja Saponaria Molina

Roner¹,

Tam

Kiesling-Barrager

2010

Future Med. Chem.

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Background-Rotavirus is the leading cause of severe diarrhea disease in newborns and young children worldwide, estimated to be responsible for over 300,000 childhood deaths every year, mostly in developing countries. Rotavirus-related deaths represent approximately 5% of all deaths in children younger than 5 years of age worldwide. Saponins are readily soluble in water and are approved by the US FDA for inclusion in beverages intended for human consumption. The addition of saponins to existing water supplies offers a new form of intervention into the cycle of rotavirus infection. We believe that saponins will 'coat' the epithelium of the host's small intestine and prevent attachment of rotavirus.

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confidence: 99%

Prevention of Rotavirus Infections In Vitro with Aqueous Extracts of Quillaja Saponaria Molina

Roner¹,

Tam

Kiesling-Barrager

2010

Future Med. Chem.

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“…A capacidade de Ab2β na indução de respostas imunológicas, tanto de anticorpos, quanto por células T para determinados patógenos tem sido demonstrada em inúmeros modelos de sistemas, incluindo os vírus, tais como vírus de leucemia murina, vírus de tumor mamário murino (MMTV), reovírus, poliovírus, vírus da raiva, vírus da hepatite B, e o vírus da imunodeficiência humana (HIV) (FRANCOTTE; URBAIN, 1984;KENNEDY, DREESMAN, 1984;KENEDDY et al, 1986;THANAVALA, ROITT, 1986;SCHICK et al, 1987;ZHOU et al, 1987ZHOU et al, , 1990OOSTERLAKEN et al, 1991;ORTEN et al, 1991;DINCA et al, 1993;AMERI et al, 2005), bactérias tais como Escherichia coli, Pneumonia streptoccus, e Brucella abortus (MCNAMARA et al1984;KAUFMANN, 1985;SU et al, 1992) (CHOI et al,2004;CUNHA et al, 2004), ou ainda em três cadeias VHs ligadas a três cadeias VLs conjugadas, formando os "triabodies" (HOLLIGER; HUDSON, 2005). Variações destes fragmentos, como por exemplo o FvFc, que se constitui em um scFv unido aos domínios CH2 e CH3 de IgG, e retém a capacidade de ligação ao antígeno e atividade efetora, também podem ser expressas em sistemas microbianos (HUSN et al, 1991).…”

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Estudo dos efeitos da terapia de scFv que mimetiza o antígeno gp43 de Paracoccidioides brasiliensis conjugado à nanocápsulas na paracoccidioidomicose experimental

Pereira¹

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“…Thus, with this approach, Id-based vaccines do not contain nominal Ag or its fragments. The ability of Ab2a and Ab2B to induce the immune responses (both antibody and T cell responses) to a given pathogen has been shown in many model systems including viruses(Dinca et al, 1993;Francotte and Urbain, 1984; Kennedy and Dressman, 1984; Kennedy and Dressman, 1986;Oosterlaken et al, 1991;Orten et al, 1991; Schick et al, 1987;Zhou et al, 1990), bacteria(Kaufmann, 1985;McNamara et al, 1984; Su et al, 1992), and parasites(Kresina and Olds, 1989; Sacks and Sher, 1983;Velge-Roussel et al, 1989). Vaccinating with anti-idiotypic antibodies (Ab2~) (that carry the internal image of the antigen) offer a number of advantages over immunizing with conventional vaccines.…”

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confidence: 99%

Immune modulation of antibody response to porcine reproductive and respiratory syndrome virus glycoprotein 5 (GP5) using anti-idiotypic antibodies in mouse model

Ameri-Mahabadi

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Porcine reproductive and respiratory syndrome (PRRS), caused by the PRRS virus (PRRSV), is a disease of great economic importance for the swine industry worldwide. PRRSV is a member of the family Arteriviridae in the order Nidovirales. PRRSV is an enveloped positive single-stranded RNA virus, which encodes an approximately 4,000-aminoacid large replicase polyprotein (open reading frame [ORF] 1 a and 1 b) and six structural proteins of 130 to 265 amino acids (ORFs 2 to 7). Three of these structural proteins have been identified as envelope (25 kDa), matrix (19 kDa), and nucleocapsid (15 kDa) proteins, i.e. GP5, M, and N proteins, respectively. PRRSV infection poses a challenge to current serodiagnostic and vaccination strategies. A better understanding of the mechanisms that regulate immunity to this virus will aid in the development of more effective vaccines, as well as serodiagnostic CHAPTER 3. Swine Auto-anti-Idiotypic Antibody Specific for Antibodies Against GPS Antigen of Porcine Reproductive and Respiratory Syndrome Virus Elicits Specific

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Efficient induction of Semliki Forest virus and mumps virus neutralizing anti-anti-idiotypic antibodies using Quil A as adjuvant

Cited by 8 publications

References 14 publications

Prevention of Rotavirus Infections In Vitro with Aqueous Extracts of Quillaja Saponaria Molina

Prevention of Rotavirus Infections In Vitro with Aqueous Extracts of Quillaja Saponaria Molina

Estudo dos efeitos da terapia de scFv que mimetiza o antígeno gp43 de Paracoccidioides brasiliensis conjugado à nanocápsulas na paracoccidioidomicose experimental

Immune modulation of antibody response to porcine reproductive and respiratory syndrome virus glycoprotein 5 (GP5) using anti-idiotypic antibodies in mouse model

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