Efficient membrane-based affinity separations for chemical applications: A review

Eygen, Gilles Van; Bruggen, Bart Van der; Buekenhoudt, Anita; Alconero, Patricia Luis

doi:10.1016/j.cep.2021.108613

Cited by 31 publications

(5 citation statements)

References 201 publications

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“…After its first development by Li et al in the late 1960s, LMs quickly gained much attention as a viable alternative to solid membranes and solvent extraction . By setting the LMs, a novel and promising separation method has emerged according to permeation and transport mechanisms for selective mass transfer. , Generally, LMs are classified into three different categories (Figure ): bulk liquid membrane (BLM), emulsion liquid membrane (ELM), and supported liquid membrane (SLM). , The structure of BLMs is made of two miscible aqueous phases (feed and strip) that are separated by an immiscible third liquid (carrier). The carrier is primarily responsible for mass transfer from one fluid (feed) to another (strip) .…”

Section: Introductionmentioning

confidence: 99%

“…7,8 Generally, LMs are classified into three different categories (Figure 1): bulk liquid membrane (BLM), emulsion liquid membrane (ELM), and supported liquid membrane (SLM). 9,10 The structure of BLMs is made of two miscible aqueous phases (feed and strip) that are separated by an immiscible third liquid (carrier). The carrier is primarily responsible for mass transfer from one fluid (feed) to another (strip).…”

Section: Introductionmentioning

confidence: 99%

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An Overview of Practical Aspects of the Design and Application of Polymeric/Ceramic Supports in Supported Liquid Membranes for Gas Separation

Faramarzi

Arzani

Khosravanian

et al. 2023

Ind. Eng. Chem. Res.

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The idea of establishing faster/facilitated transport through liquid membranes (LMs) is both theoretically fascinating and promising for applications. One of the most selective, along with lots of desirable promising forms of LMs, is supported liquid membranes (SLMs). Since the introduction of the idea of SLMs a few decades ago, research activities in this sector have been continuously increased. Through a comprehensive analysis of the current state of the art, this review demonstrates the design and application considerations that must be made when determining whether to employ polymeric or ceramic supports in SLMs for gas separation. Following a thorough analysis of the principles of LMs, including their chronology, transport mechanism, and advantages and disadvantages are presented. The various configurations suggested up to date, their road from the laboratory to practical implementation, and their performance are discussed. Finally, potential challenges and opportunities are outlined.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Overview of Practical Aspects of the Design and Application of Polymeric/Ceramic Supports in Supported Liquid Membranes for Gas Separation

Faramarzi

Arzani

Khosravanian

et al. 2023

Ind. Eng. Chem. Res.

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“…The properties of siloxane polymers are mainly determined by the structure of the main chain and the type of organic substituent at the silicon atom. Membranes based on linear (polydimethylsiloxane (PDMS) and (polymethyloctylsiloxane (POMS)) and substituted polysiloxanes are used in most processes where continuous selective layer membranes are used: gas separation [ 16 ], vapor separation [ 17 ], pervaporation [ 18 ], nanofiltration of organic media [ 19 ], perstraction [ 20 ], gas–liquid membrane contactors [ 21 ], and even electrodialysis [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Pervaporation and Gas Separation Properties of High-Molecular Ladder-like Polyphenylsilsesquioxanes

et al. 2023

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This paper presents the results of studies on the pervaporation properties (for benzene/hexane mixtures) and gas permeability (for He, H2, N2, O2, CO2, CH4, C2H6, and C4H10) of ladder-like polyphenylsesquioxanes (L-PPSQ) with improved physical and chemical properties. These polymers were obtained by condensation of cis-tetraphenylcyclotetrasiloxanetetraol in ammonia medium. The structure of L-PPSQ was fully confirmed by a combination of physicochemical analysis methods: 1H, 29Si NMR, IR spectroscopy, HPLC, powder XRD, and viscometry in solution. For the first time, a high molecular weight of the polymer (Mn = 238 kDa, Mw = 540 kDa) was achieved, which determines its improved mechanical properties and high potential for use in membrane separation. Using TGA and mechanical analysis methods, it was found that this polymer has high thermal (Td5% = 537 °C) and thermal-oxidative stability (Td5% = 587 °C) and good mechanical properties (Young’s module (E) = 1700 MPa, ultimate tensile stress (σ) = 44 MPa, elongation at break (ε) = 6%), which is important for making membranes workable under various conditions. The polymer showed a high separation factor for a mixture of 10% wt. benzene in n-hexane (126) at a benzene flow of 33 g/(m2h).

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“…Membrane contactors, which provide interfaces between product solutions and extraction phases, have the potential to tackle the above limitations. The applications of membranes in biocatalytic processes and various other applications have been reviewed elsewhere. − Nowadays, pilot-scale and full-scale applications of membrane contactors have been demonstrated in the chemical, pharmaceutical, biotechnological, environmental, and food processing areas . Particularly for ATA-catalyzed chiral amine production, membrane extraction is applied for ISPR to shift the reaction equilibrium.…”

Section: Introductionmentioning

confidence: 99%

A Techno-economic Assessment of a Biocatalytic Chiral Amine Production Process Integrated with In Situ Membrane Extraction

Yang

Buekenhoudt²,

Dael

et al. 2022

Org. Process Res. Dev.

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The production of chiral amines through asymmetric synthesis using amine transaminase (ATA) has the potential for high yields in an efficient single-step process. Integrating in situ membrane extraction with this biocatalytic chiral amine production process has been demonstrated to reach higher yields by shifting the equilibrium position through product recovery. To date, however, it is unclear whether the in situ product recovery strategy is economically viable. This study carried out a techno-economic assessment to understand the main drivers of the manufacturing costs and to set quantitative development targets. The chiral amine products under study are (R)-(+)- or (S)-(−)-α-methylbenzylamine (MBA) and sitagliptin. Their manufacturing costs were quantified and benchmarked to three alternative production pathways. The results yield an MBA manufacturing cost of €17.8/mol for the integrated process with membrane extraction, which is lower than the cost for the benchmark process using an ion-exchange resin (€23.4/mol). The sitagliptin manufacturing cost is estimated to be €30.9/mol, which is €1.6/mol and €4.6/mol less than the benchmark process with engineered transaminase and the rhodium-catalyzed process, respectively. On the basis of the outcomes of sensitivity analyses, development targets were set for the membrane flux and selectivity and the product concentration, which are the key parameters that influence the manufacturing cost related to the membrane.

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Efficient membrane-based affinity separations for chemical applications: A review

Cited by 31 publications

References 201 publications

An Overview of Practical Aspects of the Design and Application of Polymeric/Ceramic Supports in Supported Liquid Membranes for Gas Separation

An Overview of Practical Aspects of the Design and Application of Polymeric/Ceramic Supports in Supported Liquid Membranes for Gas Separation

Pervaporation and Gas Separation Properties of High-Molecular Ladder-like Polyphenylsilsesquioxanes

A Techno-economic Assessment of a Biocatalytic Chiral Amine Production Process Integrated with In Situ Membrane Extraction

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