Cross-ISA (Instruction Set Architecture) system-level virtual machine has a significant research and practical value. For example, several recently announced virtual smart phones for iOS which run smart phone applications on x86 based PCs are deployed on cross-ISA system level virtual machines. Also, for mobile device application development, by emulating the Android/ARM environment on the more powerful x86-64 platform, application development and debugging become more convenient and productive. However, the virtualization layer often incurs high performance overhead. The key overhead comes from memory virtualization where a guest virtual address (GVA) must go through multilevel address translation to become a host physical address (HPA).